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Biomedical subjects

W E Luper

Publications and source records attributed to W E Luper.

5 recordsLinked to original sources
PubMed1993

Transfusion-associated Chagas' disease in Texas: report of a case.

A 59-year-old woman with metastatic colon cancer, immunosuppressed secondary to chemotherapy and prolonged granulocytopenia, developed acute Chagas' disease that was fatal. During her illness, she received transfusions with large numbers of blood components. Although we were unable to identify an infected donor, we believe her infection was acquired from transfusion of a contaminated blood component. Recently, three similar cases were reported in North America. An influx of immigrants from areas in which Chagas' disease is endemic may account for the increased number of cases of transfusion-associated Chagas' disease in this country.

Animals↗
PubMed1981

Assays of serum aminoglycoside levels by BACTEC 460 in the presence of cefamandole and cefoxitin.

The effects of cefamandole and cefoxitin on the assays of serum containing gentamicin, tobramycin, or amikacin by the BACTEC 460 (Johnston Laboratories, Cockeysville, Md.) were studied. The results were analyzed to determine whether the presence of the test substances, cefamandole or cefoxitin, caused a statistically different mean value of aminoglycoside or increase in variance as compared with serum assayed in their absence. The results were then considered in light of medical significance to see whether the difference observed would have any real effect on patient care. The results of each analyses dictate that serum of patients treated with both amikacin and cefamandole be tested in triplicate.

Amikacin↗
PubMed1978

Total support of the circulation of a patient with post-cardiotomy stone-heart syndrome by a partial artificial heart (ALVAD) for 5 days followed by heart and kidney transplantation.

A patient with acute bacterial endocarditis in whom ischaemic contracture of the left ventricle (stone-heart syndrome) developed during aortic and mitral valve replacement had an emergency implantation of an intracorporeal partial artificial heart (an abdominal left-ventricular assist device of ALVAD). This device functioned as a total artificial heart for nearly 6 days, while a donor heart for transplantation was sought. The ALVAD was then removed, and the patient received allografts of a heart and a kidney. The transplanted heart functioned well, but the patient died 15 days later from gram-negative sepsis. There was no evidence of cardiac or renal allograft rejection.

Acute Disease↗