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Biomedical subjects

W E Jackson

Publications and source records attributed to W E Jackson.

47 records · Page 3Linked to original sources
PubMed1985

Ocular and systemic abnormalities associated with morning glory syndrome.

The term: 'morning glory syndrome' is currently used to describe a clinical complex encompassing a primarily congenital, possibly hereditary optic nerve anomaly associated with other ocular and systemic abnormalities. This syndrome has been shown to be usually limited to the eye with non-involvement of the retrobulbar nerve and brain. However, recent studies have illustrated that morning glory syndrome may be associated with such systemic abnormalities as sphenoidal encephalocele. The authors present a review of the current literature and functionally analyze the incidence of retinal detachment, pre-retinal gliosis, increased production of fibrovascular tissue and other ocular abnormalities; as well as exploring the association of systemic involvement; utilizing fluorescein angiography, computerized tomography, ultrasonography and electrophysiology.

Child↗
PubMed1984

Unilateral osseous choristoma of the choroid.

We describe a case of unilateral choroidal osteoma in a young white women referred to our office for evaluation of a possible malignant melanoma. The characteristic findings corresponding with other reported cases in the literature are a slightly elevated, yellow-white choroidal tumor lying in the posterior pole with the borders well defined; depigmentation of the pigment epithelium; and vascular tuft networks located on the tumor's surface. Our findings were characteristic of the previously observed choroidal osteoma results. Equator-plus photography was utilized for improved visualization of tumor size and activity. The pertinent clinical testing procedures aiding in the identification of this entity are presented.

Adult↗
PubMed1983

Distribution of 14C-labelled acrylamide and betaine in foetuses of rats, rabbits, beagle dogs and miniature pigs.

[14C]Acrylamide and [14C]betaine hydrochloride were administered in a single iv dose to pregnant rats, rabbits, beagle dogs and miniature pigs late in gestation (1-2 days before expected parturition). Dosages used were 10 mg/kg for rats and 5 mg/kg for the other species. The compounds were allowed to equilibrate in the animal (for 1 hr in rats and for 2 hr in the other species); the dam was then killed and the foetuses were removed by caesarean section. Each foetus was weighed and analysed for radioactivity, either by homogenization of the whole foetus (rat and rabbit) or by determining separately the radioactivity in individual organs and tissues (dog and pig). Foetal uptake of the polar compound betaine hydrochloride was much lower than that of the more lipophilic acrylamide. The sex of the foetus did not appear to affect uptake of either compound. There were no significant differences in total uptake of isotope attributable to the position of the foetus within the uterus in any of the four species given either acrylamide or betaine. Similarly, uterine position did not affect the uptake of acrylamide or betaine by individual tissues of foetal dogs or pigs. Since the distributions of 14C-labelled acrylamide and betaine hydrochloride were essentially uniform throughout a litter, it would not be necessary to sample all of the members of a litter to obtain a representative picture of foetal distribution.

Acrylamides↗
PubMed1969

Tarsorrhaphy.

Explore the source record for details and available documents.

Eyelids↗
PubMedDate not supplied

Oncogenic potential of hyperthermia in combination with radiation.

The C3H 10T1/2 mouse embryo cell line was used to determine the effect of hyperthermia on the in vitro oncogenic transforming potential of radiation. Heat exposures at 45 degrees C/15 min or at 43 degrees C/60 min administered alone yielded no significant transformation as previously reported. However, our recent results repeat our earlier findings that there is an increase in the in vitro transformation frequency after the combined treatment of hyperthermia and radiation, if foci/flask or foci/surviving cell are used to calculate transformation frequency, if high temperature exposures are used (e.g. 43 degrees C/60 min or 45 degrees C/15 min) and if the time between the combined treatments of hyperthermia and 200 cGy of 60Co radiation is < or = 5 min at ambient temperature. As can be seen in this and past reports whether the combination of hyperthermia and radiation show an increase, a decrease, or no change in in vitro oncogenic transformation, a number of factors are critical. These critical factors are (1) temperature/exposure time and radiation dose as expected; (2) stage of the cell cycle and growth conditions at each exposure; (3) time between treatments; and (4) method of data analysis, i.e. whether the transformation frequency was based on the foci/viable cells, foci/flask or the foci/total cells at risk (total cells plated x plating efficiency of the untreated cells). Recent publications have shown that the position of cells in the cell cycle determine the frequency of cell transformation (Cao et al. 1992, Miller et al. 1992). Factors 1-3 affect the cells position in the cell cycle.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMedDate not supplied

Comparative intestinal and testes toxicity of four aminothiols in irradiated and nonirradiated mice.

Intestinal and testicular toxicity in groups of nonirradiated and irradiated mice were investigated after intraperitoneal injection of aminothiol compounds or saline. Four aminothiols were studied. Three were prodrugs: WR-2721, WR-3689, and WR-151327 and one was the active form of WR-2721: WR-1065. Thirty minutes after injection, the mice were sham-irradiated or bilaterally exposed (whole body) to 60Co gamma-irradiation at a dose rate of 1 Gy per min to a total dose of 15 Gy. Four days after injection, mice were euthanised, and the intestines and testes were removed and histologically examined. The intestinal crypt cell number was increased in all the irradiated mice given WR-compounds compared to controls (P < 0.05). Interestingly, the crypt cell number in nonirradiated mice given WR-1065 was also greater than control or WR-2721 (P < 0.05) treated mice. Germinal cell numbers from testes of mice administered aminothiols prior to radiation decreased or did not change. Some swelling of the seminiferous tubules was also observed. The germinal cell numbers in sham-irradiated mice were also less than the controls. Thus, aminothiol addition can provide limited protection to intestinal crypt cells but not to germinal cells of the testes in response to gamma-irradiation. There is also evidence that aminothiols are toxic to the germinal cell layer of the seminiferous tubules when given to sham-irradiated mice.

Amifostine↗