Search PubMed⌕ Search

Biomedical subjects

W E Garrett

Publications and source records attributed to W E Garrett.

At least 37 records · Page 2Linked to original sources

What would you do? Acute extension block caused by anterior cruciate ligament tear: a case report.

Acute knee locking is usually attributed to a displaced meniscus tear. This case involved late diagnosis of mechanical extension block caused by anterior displacement of a torn anterior cruciate ligament (ACL) with impingement in extension. Definitive reconstruction was delayed after debridement of the ACL stump to improve preoperative range of motion. Despite this, the patient still had difficulty regaining extension after surgery. Early treatment of mechanical extension block may facilitate motion recovery after ACL reconstruction.

Adolescent↗

Muscle strain injuries.

One of the most common injuries seen in the office of the practicing physician is the muscle strain. Until recently, little data were available on the basic science and clinical application of this basic science for the treatment and prevention of muscle strains. Studies in the last 10 years represent action taken on the direction of investigation into muscle strain injuries from the laboratory and clinical fronts. Findings from the laboratory indicate that certain muscles are susceptible to strain injury (muscles that cross multiple joints or have complex architecture). These muscles have a strain threshold for both passive and active injury. Strain injury is not the result of muscle contraction alone, rather, strains are the result of excessive stretch or stretch while the muscle is being activated. When the muscle tears, the damage is localized very near the muscle-tendon junction. After injury, the muscle is weaker and at risk for further injury. The force output of the muscle returns over the following days as the muscle undertakes a predictable progression toward tissue healing. Current imaging studies have been used clinically to document the site of injury to the muscle-tendon junction. The commonly injured muscles have been described and include the hamstring, the rectus femoris, gastrocnemius, and adductor longus muscles. Injuries inconsistent with involvement of a single muscle-tendon junction proved to be at tendinous origins rather than within the muscle belly. Important information has also been provided regarding injuries with poor prognosis, which are potentially repairable surgically, including injuries to the rectus femoris muscle, the hamstring origin, and the abdominal wall. Data important to the management of common muscle injuries have been published. The risks of reinjury have been documented. The early efficacy and potential for long-term risks of nonsteroidal antiinflammatory agents have been shown. New data can also be applied to the field with respect to the beneficial effects of warm-up, temperature, and stretching on the mechanical properties of muscle. These benefits potentially reduce the risks of strain injury to the muscle. Fortunately, many of the factors protecting muscle, such as strength, endurance, and flexibility, are also essential for maximum performance. Future studies should delineate the repair and recovery process emphasizing not only the recovery of function, but also the susceptibility to reinjury during the recovery phase.

Animals↗

The effects of the Ilizarov distraction technique on bone and muscle in a canine model: a preliminary report.

This study examined the functional and morphological changes experienced by bone and muscle during Ilizarov distraction osteogenesis. Although extensive research has been conducted in the area of regenerate bone formation, the effect of limb lengthening on the biomechanical properties of bone and muscle has not been thoroughly addressed. In this study, an Ilizarov external fixator was applied to one tibia of nine skeletally mature dogs, and distracted 3 cm over thirty days. The contralateral tibia served as control. Histology and weekly radiographs assessed muscle morphology and bone growth. The contractile capabilities of the gastrocnemius muscles from the experimental and control limbs were measured prior to sacrifice, and the bending stiffness of the tibias of five dogs was determined. All dogs experienced loss of knee extension secondary to muscle contracture and/or stiffness about the joint. These dogs did not bear weight on the experimental limb. In one dog, spontaneous resolution of the muscle contracture allowed partial weight bearing during the last three weeks of consolidation. Despite 3 cm distraction, tibial lengthening ranged from 1.7 to 3 cm. Biomechanical testing revealed a significant reduction in the bending stiffness of the lengthened bones when compared with control values (p < 0.003). The weight of the lengthened muscles was 35% less than control values, a finding consistent with the histology which showed mild muscle fiber degeneration in all dogs. The contractile capabilities of the lengthened muscles were reduced to 29-80% of control values (p < 0.005). In contrast, the lengthened muscle from the weight bearing dog retained 85% of the weight and 104% of the maximum contractile force of the control muscle.

Animals↗

Axial strain measurements in skeletal muscle at various strain rates.

A noncontact optical system using high speed image analysis to measure local tissue deformations and axial strains along skeletal muscle is described. The spatial resolution of the system was 20 pixels/cm and the accuracy was +/- 0.125 mm. In order to minimize the error associated with discrete data used to characterize a continuous strain field, the displacement data were fitted with a third order polynomial and the fitted data differentiated to measure surface strains using a Lagrangian finite strain formulation. The distribution of axial strain along the muscle-tendon unit was nonuniform and rate dependent. Despite a variation in local strain distribution with strain rate, the maximum axial strain, Exx = 0.614 +/- 0.045 mm/mm, was rate insensitive and occurred at the failure site for all tests. The frequency response of the video system (1000 Hz) and the measurement of a continuous strain field along the entire length of the structure improve upon previous noncontact optical systems for measurement of surface strains in soft tissues.

Animals↗

Characterization of the passive responses of live skeletal muscle using the quasi-linear theory of viscoelasticity.

The tensile viscoelastic responses of live, innervated rabbit skeletal muscle were measured and characterized using the quasi-linear model of viscoelasticity. The tibialis anterior (TA) and extensor digitorum longus (EDL) muscles of anesthetized New Zealand white rabbits were surgically exposed and tested under in vivo conditions. Rate sensitivity of the force-time history was observed in response to constant velocity testing at rates from 0.01 to 2.0 Hz. Average hysteresis energy, expressed as a percentage of maximum stored strain energy, was 39.3 +/- 5.4% and was insensitive to deformation rate. The quasi-linear model, with constants derived from relaxation testing, was able to describe and predict these responses with correlation exceeding the 99% confidence interval for the 132 constant velocity tests performed (rmean = 0.9263 +/- 0.0373). The predictive ability of this model was improved when compressive loading effects on the muscle were neglected, rmean = 0.9306 +/- 0.0324. The rate insensitivity of hysteresis energy was predicted by the model; however, the absolute value of the hysteresis was underestimated (30.2 +/- 4.0%). Both muscles demonstrated strikingly different elastic functions. Geometric normalization of these responses (stress and strain) did not result in a single elastic function capable of describing both muscles. Based on these results, the quasi-linear model is recommended for the characterization of the structural responses of muscle; however, further investigation is required to determine the influence of muscle geometry and fiber architecture on the elastic function.

Animals↗

Graft isometricity in unitunnel anterior cruciate ligament reconstruction: analysis of influential factors using a radiographic model.

A radiographic model was developed to investigate the influence of three surgical variables on the change in attachment point distance (CAPD) of a hypothetical graft using the unitunnel technique of anterior cruciate ligament (ACL) reconstruction. Using three different femoral target points, we tested the hypothesis that varying the angle of knee flexion between 70 degrees and 110 degrees and varying the tibial starting point over a 4-cm range do not result in a significant variation in CAPD. We also tested the hypothesis that the CAPD from 0 degrees to 135 degrees is greater than the CAPD from 0 degrees to 90 degrees. There was a statistically significant correlation (r = 0.8465, P < 0.0001) between radiographically estimated and isometer-measured values of CAPD. The tibial starting point and the femoral target point were found to affect the CAPD significantly (P < 0.005). A more proximal tibial starting point was associated with a lower CAPD. Both the center of the anatomic femoral attachment of the ACL, and a point 1 mm medial to the junction of the roof and lateral wall of the femoral intercondylar notch and 6 mm anterior to its posterior margin, were associated with lower CAPD values than a target point 5 mm superior and posterior to the center of the femoral ACL attachment. The angle of knee flexion did not significantly affect the CAPD. The CAPD [0 degrees-135 degrees] was significantly greater than the CAPD [0 degree-90 degrees] for all combinations of variables (P < 0.0005).(ABSTRACT TRUNCATED AT 250 WORDS)

Anterior Cruciate Ligament↗

The medial patellofemoral ligament revisited: an anatomical study.

The purpose of this study was to provide a comprehensive description of the anatomy of the medial patellofemoral ligament (MPFL). The anterior and medial aspects of 4 unpreserved and 16 preserved cadaveric human knees were dissected with particular attention being paid to the relationship of the various layers to one another and to the place of the MPFL within these layers. We confirmed that the MPFL is a distinct structure lying within layer II. Its bulk varies considerably between individuals but not from side to side in a given individual. The visualisation, attachments, and gross morphology of the ligament are described. The attachments of the MPFL and the orientation of its fibres suggest that it may have a role in limiting lateral excursion of the patella. The common attachment of the tendon of the vastus medialis muscle and the ligament to the superomedial patella suggests that there may be a dynamic element to such a stabilising function.

Adult↗

Restriction of the injury response following an acute muscle strain.

Indirect skeletal muscle injuries have been found to occur exclusively near the myotendinous junction (MTJ). Although muscle cells are syncytial and extend far into the muscle belly, the response to this injury has been shown to be limited to a focal area near the MTJ. This study examined single muscle fibers near their site of rupture in order to document structural changes that may help to explain this limited injury response. A partial, nondisruptive strain injury was created in a New Zealand white rabbit extensor digitorum longus muscle. The muscles were left in vivo for 60 min or 6 h before harvesting. The specimens were divided into four groups of single fibers: ruptured fibers (60 min) attached to muscle belly (group I); ruptured fibers (60 min) attached to tendon (group II); ruptured fibers (6 h) attached to muscle belly (group III); and normal, unstretched fibers (60 min) at the MTJ (group IV) (N = 10 for each group). Sarcomeres closest to the site of fiber rupture in the three injured groups (I, II, and III) were hypercontracted, with lengths well below the physiologic range (I: 0.86 +/- 0.08 microns, II: 0.96 +/- 0.09 microns, III: 0.96 +/- 0.21 microns). There was a progressive increase in sarcomere length, which became normal by 300-500 microns away from the site of rupture (I: 2.17 +/- 0.48 microns, II: 2.69 +/- 0.42 microns, III: 2.08 +/- 0.48 microns). The 6-h fibers in group III showed evidence of necrosis before the transition to normal sarcomere spacing occurred.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

Injuries at the myotendinous junction.

The complete role of the myotendinous junction is discussed in this article. The morphology and function of the junction, typical injuries occurring at this region, delayed-onset muscle soreness, and muscle strain injury are described. Muscle strain injury is covered in detail, including characterization, treatment, and prevention. Clinical information is conveyed as well as basic science study results pertinent to the clinical situation.

Animals↗

Arthroscopic subacromial decompression: results in advanced impingement syndrome.

A study group composed of 25 shoulders in 24 patients underwent arthroscopic subacromial decompression for advanced impingement syndrome. There were no full thickness rotator cuff tears, biceps tendon ruptures, significant acromioclavicular arthrosis, or evidence of glenohumeral instability. Twenty men and four women ranging in age from 18 to 63 years (mean age 37) with dominant arm involvement in 17/24 were evaluated for an average follow-up of 20.3 months (range 14-32) postoperatively. Operative results were based on the UCLA shoulder rating scale. Eighty-eight percent of the cases (22/25) had good or excellent results. Twelve percent had fair results (3/25). There were no poor results. The average UCLA pain score improved from 2.6 preoperative (constant pain) to 7.8 postoperative (occasional pain). Ninety-two percent of the patients were satisfied, said they were better, and that they would have the surgery again. Arthroscopic subacromial decompression is recommended as an alternative to open anterior acromioplasty in advanced impingement syndrome.

Acromioclavicular Joint↗

Anterior staple capsulorrhaphy for recurrent dislocation of the shoulder: a clinical and biomechanical study.

Thirty-three anterior staple capsulorrhaphies of the shoulder were reviewed at an average 49.7 months postoperatively (range 12 to 127 months); one postoperative dislocation occurred. The patients' quality of athletic participation improved with surgical therapy in 50%, remained the same in 38%, and was lowered in 12%. Average loss of external rotation was 11.4 degrees with the arm adducted and 13.9 degrees with the arm abducted 90 degrees. A positive apprehension sign persisted in 50%. Shoulder function was good or excellent in 84%. Mild pain was admitted by 55%, moderate pain by 6%, and severe pain by 3%. Staple malpositioning or loosening was identified in 12 shoulders; six of these patients had attributable clinical problems. Biomechanical studies in porcine bone were used to demonstrate that predrilling facilitates proper staple positioning without compromising staple fixation strength and, in a synthetic trabecular model, that a 5 degrees variance in the alignment of the staple holder during staple insertion weakens the fixation strength by 51% (P less than .001). The operation usually prevents recurrent dislocation, permits recovery of normal (or near normal) shoulder motion, and allows satisfactory return to competitive athletics. If staple malpositioning and loosening occur, they may cause clinical problems, including degenerative arthritis. Though most patients (92%) stated they would again have the operation, when practical, we recommend other methods of repair of capsule and labral detachment.

Adult↗

Evaluation of acute traumatic hemarthrosis of the knee joint.

Acute hemarthrosis of the knee usually results from a significant injury. Preoperative assessment, examination under anesthesia, and arthroscopic examination were conducted on patients with a total of 132 acutely injured knees associated with hemarthrosis and minimal clinical laxity to determine the presence and extent of injury to ligamentous and/or intra-articular structures. Partial or complete tear of the anterior cruciate ligament was found in 101 (77%) of the knees. Peripheral meniscal tears were responsible for the hemarthrosis in 17 cases (13%), and osteochondral fractures were found in 11 cases (8%). Injury to the anterior cruciate ligament was frequently associated with concomitant injury to other structures: meniscal tears (61%), ligament/capsular injury (40%), and hyaline chondral damage (16%). Patients' responses to preoperative anterior drawer, pivot shift, and Lachman tests were within normal limits in 18%, 29%, and 73% of cases, respectively. Patients under anesthesia responded to the anterior drawer and pivot shift tests normally 50% and 74% of the time. The Lachman test, performed under anesthesia, was 98% accurate in predicting anterior cruciate injury. Experience gained in evaluating posttraumatic hemarthrosis of the knee suggests clinical examination alone may not demonstrate the severity of many of these injuries. Arthroscopy, although not necessary to determine competence of the anterior cruciate ligament, is invaluable in determining the existence of other injuries with or without an associated anterior cruciate ligament tear.

Acute Disease↗

Muscle strain injuries: clinical and basic aspects.

Indirect or strain injury to muscle is a common cause of athletic disability. Strain injuries often occur during powerful muscle eccentric contractions. Clinical studies suggest that most injuries cause partial disruption of certain characteristic muscles. Diagnostic imaging studies can demonstrate the location of many injuries. Laboratory studies show that partial and complete injuries exhibit disruption of muscle fibers near the muscle-tendon junction. Healing of partial injuries is characterized by an initial inflammatory response followed by a healing phase marked by fibrosis. Biomechanical studies show that muscle failure occurs at forces much larger than maximal isometric force, and stretch is necessary to create injury. Compared to the passively stretched muscle, muscle activated by nerve contraction and stretched to failure attains a small increase in force at failure, no change in strain to failure, and a large increase in energy absorbed prior to failure. These studies emphasize the ability of muscles to function as energy absorbers in preventing injury to themselves and to bones and joints. Experimental muscle stretching protocols show significant stress relaxation and reduction of stiffness in muscle due to inherent viscoelastic properties of muscle rather than to reflex-mediated effects. These viscoelastic properties may be useful in understanding how muscle injury might be prevented.

Biomechanical Phenomena↗

Warm-up and muscular injury prevention. An update.

Musculotendinous injuries are responsible for a significant proportion of injuries incurred by athletes. Many of these injuries are preventable. Importantly, musculotendinous injuries have a high incidence of recurrence. Thus, muscle injury prevention is advocated by coaches and trainers. Yet, most of the recommendations for muscle injury prevention are attempted by athletes and taught by coaches without supporting scientific evidence. This paper reviews the mechanics of muscular injury, associated and predisposing factors, and methods of prevention with a review of the supporting research and rationale for these methods with an emphasis on warm-up, stretching and strengthening. Muscles that are capable of producing a greater force, a faster contraction speed and subjected to a greater stretch are more likely to become injured. Many factors have been associated with muscular injury. From current research, some conclusions and recommendations for muscle injury prevention can be made. Overall and muscular conditioning and nutrition are important. Proper training and balanced strengthening are key factors in prevention of musculotendinous injuries as well. Warm-up and stretching are essential to preventing muscle injuries by increasing the elasticity of muscles and smoothing muscular contractions. Improper or excessive stretching and warming up can, however, predispose to muscle injury. Much research is still needed in this important aspect of sports medicine.

Athletic Injuries↗

Computed tomography of hamstring muscle strains.

Acute hamstring muscle strains occurring in ten college athletes were evaluated using computed tomography to identify the location and characteristics of these common injuries. Acute muscle strains appeared as areas of hypodensity within the muscle 1-2 d following injury. This suggests that inflammation and edema are the major component of injury, not bleeding as commonly assumed. Injuries were seen most commonly in the proximal and lateral portions of the hamstring muscle group, particularly in the biceps femoris.

Adult↗

Injury to the lateral ligaments of the ankle.

Ankle sprains are common and often are treated inadequately. Unstable lateral ankle ligaments cause abnormal ankle motion and can lead to degenerative changes. Arthrography is the superior radiographic study in acutely injured ankles. Stress tests are useful if positive; however, because false-negative tests are common, general anesthesia should be considered. Chronic injuries may be evaluated well with stress testing. Conservative treatment (that is, mobilization) with aggressive rehabilitation is probably the best treatment for all lateral ligament injuries, unless certain mechanical stability is of paramount importance. Finally, the results of late reconstruction equal those of early repair.

Ankle Injuries↗