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Biomedical subjects

W E Allen

Publications and source records attributed to W E Allen.

At least 91 records · Page 5Linked to original sources
PubMed1981

Indigenous nasopharyngeal, auditory canal, and middle ear bacterial flora of gerbils: animal model for otitis media.

The indigenous microbial flora of the middle ear cavity of Mongolian gerbils, Meriones unguiculatus, was isolated, characterized, and identified, showing it to be sparse and transitory. Organisms, when found in the middle ear cavity, were most likely to be Staphylococcus epidermidis-like organisms. Cerumen from the external auditory canal of these animals yielded mostly staphylococci, coryneforms, and other gram-positive rods, including some anaerobic species. The nasopharynx supported a flora consisting mainly of staphylococci, lactobacilli, and coryneforms, with a smaller incidence and numbers of many other species. No mycoplasmas were cultured or seen in scanning electron microscope studies. None of the major pathogens of human otitis media were found; therefore, Mongolian gerbils are microbiologically acceptable candidates as a model for induced otitis media, using organisms isolated from human otitic infections.

Animals↗
PubMed1981

Effect of repeated biopsy sampling on endometrial concentrations of sodium benzylpenicillin following intramuscular injection in pony mares.

Endometrial concentrations of sodium benzylpenicillin were determined in biopsy samples from anoestrous pony mares after intramuscular administration of the penicillin at 22,000 iu/kg. Serum samples, collected at the same time as biopsies, were also assayed for their penicillin content. In experiment 1 a single pair of blood and tissue samples was taken from each mare between five and 360 minutes after injection. In experiment 2 each mare was sampled consecutively six times (between five and 300 minutes) after injection. Both serum and endometrial concentration reached a peak between 15 and 30 minutes after injection. Tissue concentrations were lower than serum, except after 180 minutes in experiment 2. This suggests that at the time intervals used in the present study, serial biopsies eventually caused an increase in the endometrial content of penicillin.

Anestrus↗
PubMed1980

Use of selective arteriography in the treatment of epistaxis.

Selective carotid arteriography can provide useful information in patients with massive epistaxis. It is limited in application because special techniques and preparation are necessary. Careful selection of patients is mandatory. It is not appropriate as a screening procedure for all patients with epistaxis. The procedure is especially useful when previous surgical control of the bleeding site has failed. Residual branches of the internal maxillary and ethmoid arteries are readily identified. The development of collateral blood flow to the nasal area from many sources can be recognized. The complexity of collateral blood flow emphasizes the necessity for controlling hemorrhage as close to the source as possible. At the same time, it suggests that long-term control of bleeding in the nasal area may fail due to this vast network of vessels.

Adolescent↗
PubMed1980

Orbital hemorrhage with loss of vision.

A 58-year-old woman had the sudden onset of unilateral painful proptosis, ophthalmoplegia, vomiting, and loss of vision. Computed axial tomography showed a mass that was greatly attenuated in the orbit. The initial reading of the internal carotid angiogram was normal, but a subtraction study showed a hypervascular lesion within the orbit with features indicating a hemangioma. Orbital decompression failed to restore the vision as intraorbital hemorrhage had irreparably damaged the optic nerve.

Carotid Arteries↗
PubMed1980

Simplified irradiation dosimetry in carcinoma of the cervix (external irradiation and one radium insertion).

Gynecologic radiation oncologists have long desired a single unit by which radiation doses to specific reference points in the pelvis can be summed. The Patterns of Care Studies, Marcial's 1976 report to the Conference on Radiation Oncology of the American Cancer Society, and other radiation oncologists advise summed doses to Point A, Point B, or the pelvic side wall. Since there is a difference in the biologic effect of high intensity, long time interval teletherapy and low intensity, short time interval brachytherapy, the rad dose obtained from each modality cannot be simply added. Ellis and Sorenson in the Nominal Standard Dose (NSD) concept have described radium conversion factors that can be used to normalize brachytherapy rads at selected reference points to equivalent teletherapy rad. The two rad doses can then be summed. A simple method found useful in 50 cases of carcinoma of the cervix, and used with a computer or readily available reference tables and with any radium system, is described and discussed. Further clinical uses of the method are suggested.

Adult↗
PubMed1979

Evaluation of uterine tube function in pony mares.

Two experimental procedures were investigated in order to assess their usefulness in diagnosing occlusion of the equine uterine tube. The starch grain test, which involves the injection of a starch suspension onto the ovary and the subsequent recovery of starch from the cervix, proved to be safe and reliable. Each tube could be investigated separately. It was found that when starch was injected onto the ovulating ovary on the day of ovulation, there was a delay of four to seven days before starch was recovered from the cervix. The phenolsulphonphthalein (PSP) test, which involves the deposition of dye solution into the uterus and its subsequent identification in urine after peritoneal absorption, was not reliable. Contamination of the urine occurred per vaginum, and the test was not unilaterally specific.

Animals↗
PubMed1979

Aspects of genital infection and swabbing techniques in the mare.

The three groups of bacteria that cause endometritis in the mare are reviewed. The different methods of swabbing are assessed and the criteria which should be observed when developing a swabbing technique listed. The choice of speculum and swabs available are described.

Animals↗
PubMed1979

Abnormalities in the oestrous cycle in the mare.

The situations and conditions that can disrupt the mares normal oestrous cycle are described. Season of the year is a major influence; maximum reproductive efficiency does not totally coincide with the artificially defined "breeding season". Other abnormalities are associated with spontaneously persistent luteal function, psychological influences over behavioural activity, the presence of endometritis, multiple ovulation, reproductive behavior after pregnancy failure and granulosa cell tumours.

Animals↗
PubMed1978

Plasma concentrations of sodium benzylpenicillin after intrauterine infusion in pony mares.

Plasma concentrations of sodium benzylpenicillin were measured following intrauterine infusion at a dose rate of 22,000 u/kg (250,000 u/ml). The reproductive status of the mare at the time of infusion did not appear to influence plasma concentrations of penicillin, but preswabbing the endometrium for bacteriological culture resulted in peak plasma concentrations which were nearly twice those found in unswabbed mares.

Animals↗
PubMed1978

Absorption of sodium benzylpenicillin from the equine uterus after local Lugol's lodine treatment, compared with absorption after intramuscular injection.

Plasma concentrations of sodium benzylpenicillin following intrauterine infusion were increased by reducing the volume of solution and expelling air from the vagina after infusion. Instillation of 10 per cent Lugol's iodine solution into the uterus before penicillin infusion further increased the absorption rate, although peak plasma levels of penicillin were less than half those which resulted from intramuscular injection of the same dose.

Absorption↗