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Biomedical subjects

W Droszcz

Publications and source records attributed to W Droszcz.

At least 19 recordsLinked to original sources
PubMed1992

Creatine kinase (CK) and creatine kinase isoenzyme (CK-MB) activity in serum before and after intravenous salbutamol administration of patients with bronchial asthma.

The effect of salbutamol, a selective beta 2-adrenergic agonist, on creatine kinase (CK) and creatine kinase isoenzyme (CK-MB) activity in serum of 20 asthmatic patients was investigated. Venous blood was obtained 30 min, 2 h and 4 h after 0.5 mg salbutamol intravenous injection of 0.5 mg salbutamol. Total creatine kinase activity was assayed on a Technico RA-1000 analyzer with the IFCC recommended method. CK-MB activity was determined using a centrifugal analyzer (Cobas Fera, Roche, Switzerland). Reagent kits were provided by Boehringer Mannheim (FRG). We observed no increase of CK-activity after salbutamol, and found a statistically significant increase of CK-MB activity. Serum CK-MB activity before treatment was 13 +/- 10/IU/l after 30 minutes drug, 31.8 +/- 19 IU/l after 2 h 27.2 +/- 17.79 and after 4 h 22.6 +/- 12 IU/l. We conclude that salbutamol exerts a cardiotoxic effect.

Adult↗
PubMed1991

[Diagnostic difficulties in Churg-Strauss syndrome].

A case of the rare Churg-Strauss disease is presented, the first such in Poland. The disease is characterized by granulomatous vasculitis, bronchial asthma and eosinophilia. Diagnostical difficulties are presented and an earlier case report of Wegener's granulomatosis is discussed which also fulfilled diagnostical criteria of the Churg-Strauss disease.

Adult↗
PubMed1991

In vitro and in vivo effect of salbutamol on histamine release from human basophils.

The effect of salbutamol, a selective beta 2-adrenergic agonist, on immunological release of histamine from leukocytes isolated from blood of 14 allergic, asthmatic patients, was investigated after in vivo or in vitro drug administration. Simultaneously, the effect of this drug on peak expiratory flow rate (PEFR) was estimated. Histamine was assayed by the single isotope-enzymatic method. Obtained results have confirmed that salbutamol is a rather poor inhibitor of histamine release from basophils. Although both administered salbutamol doses (0.5 or 1 mg, i.v.) significantly increased PEFR (p less than 0.01), inhibitory effect on histamine release by allergen was seen only after higher dose administration in vivo (p less than 0.01 against control). Similarly, a small but significant decrease in histamine release by both concanavalin A (by 20%, p less than 0.01) and allergen (by 30%, p less than 0.025) was seen in vitro after incubation of leukocytes with 8 x 10(-6) mol/l salbutamol, whereas 4 x 10(-7) mol/l salbutamol was without effect.

Adult↗
PubMed1991

[Significance of anti-neutrophil cytoplasmic autoantibodies in the diagnosis of Wegener's granulomatosis].

A case of Wegener's granulomatosis (WG) with involvement of the upper and lower respiratory tract and kidneys is presented. Despite specific symptoms the diagnosis was changed several times. Final diagnosis was made with immunofluorescence test for antineutrophil-cytoplasm antibodies (IF-ANCA). In Poland, this is the first report emphasizing the role of ANCA in diagnosis of WG. The significance of this test in diagnosing of WG is presented.

Antibodies, Antineutrophil Cytoplasmic↗
PubMed1991

[Transthoracic lung biopsy (TBP)].

The results of transthoracic lung biopsy using the Nordenströms method are discussed. Basing on this technique lung biopsies were performed in 138 patients suspected of pulmonary malignancy. High diagnostic efficacy, simplicity of this method and low incidence of side effects characterize this method.

Biopsy↗
PubMed1991

[A case of B-cell lymphoma imitating bronchocentric granulomatosis].

A case is presented of primary, pulmonary B-cell lymphoma imitating bronchocentric granulomatosis. The initial manifestations were of multiple, pulmonary nodules, without intra- and extrathoracic lymph node, bone marrow and spleen involvement. Despite the initial removal of the affected pulmonary tissue the progression of the disease led to additional immunohistochemical evaluation of the resected tissue and final diagnosis. The authors also carry out a differential diagnosis of the reported changes.

Adult↗
PubMed1991

[Wegener's granulomatosis. The value of correct diagnosis and treatment].

Two cases of Wegener's granulomatosis are presented. The first case due to improper diagnosis died five months following initial clinical symptoms. The second case was diagnosed basing on clinical findings. Cyclophosphamide produced a quick and full remission. Both cases illustrate the need of proper diagnosis and introduction of treatment.

Adult↗