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Biomedical subjects

W Dodge

Publications and source records attributed to W Dodge.

18 recordsLinked to original sources
PubMed1994

Improved outcome for high-risk acute myeloid leukemia patients using autologous bone marrow transplantation and monoclonal antibody-purged bone marrow.

We have conducted a 9-year multicenter trial of autologous bone marrow transplantation (ABMT) for acute myeloid leukemia (AML). Remission BM was purged in vitro using monoclonal antibodies (MoAbs; PM-81, AML-2-23) and complement targeting myeloid differentiation antigens (CD15, CD14). In 1988, the preparative regimen changed from 60 mg/kg/d cyclophosphamide x 2 and fractionated total body irradiation (TBI) total dose, 1,200 cGy (Cy/fTBI), to 4 mg/kg/d busulfan x 4 and 60 mg/kg/d Cy x 2 (Bu/Cy2). Recent analysis (October 1, 1993) shows that the Bu/Cy2 regimen along with the same MoAb purging method yields an improved outcome. Seven first complete-remission (CR) (CR1), 45 second- or third-CR (CR2/3), and 11 first-relapse (R1) patients were treated with chemotherapy and TBI or chemotherapy alone followed by ABMT with MoAb-purged BM. Median age at ABMT for those patients in CR 2/3 and R1 patients was 36 years. Twenty-nine CR 2/3 and R1 patients were conditioned with Cy/fTBI, and 27 CR2/3 and R1 patients were conditioned with Bu/CY. Using the Kaplan-Meier method, the CY/fTBI, CR2/3, and R1 patients have a 3-year disease-free survival (DFS) of 21%. On the other hand, the Bu/Cy2, CR2/3, and R1 patients have a 3-year DFS of 48%. Nineteen CR2/3 and R1 patients relapsed post-ABMT. On analysis by conditioning regimen, those treated with Cy/fTBI have a 3-year relapse rate (RR) of 58%, whereas the patients conditioned with Bu/Cy2 have a 39% 3-year RR. Long-term DFS can be achieved in about 50% of patients with advanced remissions and relapsed AML using Bu/Cy2 with MoAb-purged BM.

Adolescent↗
PubMed1992

1987 to 1991 cost and utilization of Class IV HIV patients.

The 1987 to 1991 direct medical costs and service utilization of Class IV Human Immunodeficiency Virus (HIV) patients cared for at a Group Health Cooperative of Puget Sound (GHC) are described and compared across four time periods: 1987-'88, 1989, 1990, and 1991. Cost and utilization information for an age- and sex-matched control group of GHC enrollees not having Class IV HIV conditions are also compared to those of the Class IV HIV group. Data are presented on pharmacy, inpatient care, outpatient visits by physician specialty, laboratory, radiology, home health/hospice and other costs. The costs of the Class IV HIV population are, on average, 20 times those of the control group. The percent distribution of the control group's costs did not experience much change from 1989 to 1991. Conversely, the Class IV HIV group experienced a shift in costs from the inpatient to outpatient setting from 1987-'88 to 1989. This shift was temporary, as the locus of care shifted back to the inpatient setting over the following 2 years. Anecdotal evidence suggests that antiretroviral treatment may have led to a period in which patients required less intensive settings to manage their illness. Inpatient costs may have increased as the initial benefit of zidovudine treatment began to wane. The Class IV HIV population had greater percent of total expenses in pharmacy, laboratory, radiology, and home health/hospice services, and lower percent of total expenses in outpatient primary and specialty care than the control group.

Adult↗
PubMed1985

Induction of colony-stimulating factor from quiescent fibroblasts by avian macrophages and monocytic leukemic cells.

Confluent, quiescent chick embryo fibroblasts maintained in protein-free medium released CSF(s) active on granulocyte and monocyte progenitors and on monocytic leukemia cells induced by avian 'myeloblastosis' virus (AMV) when exposed to formaldehyde-fixed AMV leukemic cells. The CSF was assayed under serum-free conditions. Of several normal cell types tested including populations enriched for blast cells, only macrophages exhibited this capacity.

Animals↗
PubMed1980

Some circulating factors which influence granulocyte-monocyte production in the chick with myeloblastic leukemia.

Soft-agar cloning was used to investigate possible granulopoietic-monopoietic regulatory defects in the chick with myeloblastic leukemia induced by avian myeloblastosis virus. The plasma levels of granulocyte-monocyte colony-stimulating activity (CSA) of normal and leukemic plasmas were the same when undiluted or unfractionated plasmas were tested. However, dilution or fractionation revealed elevations in plasma CSA levels in the leukemic animals. Most of the activity in both normal and leukemic plasma eluted in the void-volume peak during Sephadex G-200 gel filtration, and the CSA levels in the leukemic peak were increased 5- to 10-fold. This increase did not reflect higher levels of an inhibitory lipoprotein eluting in the void volume since the differential between normal and leukemic plasma was present after delipidation. We therefore investigated the possibility that a nonlipoprotein inhibitor was present. Sephadex G-200 chromatography of leukemic plasma revealed that a potent inhibitor of colony formation was present in one of the peaks of material eluting from the column. Eight micrograms of this material inhibited colony formation by 50%. This inhibitory material was not detected in corresponding fractions obtained after chromatography of normal plasma. These data show that plasma from the chick with myeloblastic leukemia has marked elevated levels of CSA and that it also contains an inhibitor of colony formation which is absent or present at very low levels in normal plasma. Finally, leukemic plasma contained abundant amounts of avian myeloblastosis virus polypeptides which are being investigated for possible relationships to the above-described activities.

Animals↗
PubMed1978

Complication rate with supine phlebography.

The incidence of complications following supine phlebography was studied in 109 patients (142 legs) retrospectively and 89 patients (106 legs) prospectively. Virtually all patients had some discomfort during the procedure, while three patients had delayed pain for up to 4 days following examination. Three patients developed hives, one of whom also had bronchospasm. There were two cases with subcutaneous extravasation. The shorter endothelial contact time of supine phlebography compared to the semiupright technique might explain the reduced incidence of pain.

Bronchial Spasm↗