[So-called anterior spondylitis, discitis und spondylodiscitis in Bechterew's disease--the key to the understanding of this disease--].
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Biomedical subjects
Publications and source records attributed to W Dihlmann.
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Cauda equina syndrome is a rare complication in advanced ankylosing spondylitis. To avoid invasive examinations a diagnostic triad is given so that etiological diagnosis can be achieved by CT.
A patient suffering from transient osteoporosis of the hip sustained a fracture of the ipsilateral collum femoris. Total hip replacement was performed. The complete specimen of the proximal femur was subjected to histological examination. The histological findings were consistent with the reparation stage of ischaemic bone necrosis of the femoral head. The authors discuss whether transient osteoporosis of the hip is a transient, i.e. self-recovering ischaemic necrosis of the femoral head.
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Computed tomography of the herniated lumbar disc, bulging disc and spinal stenosis represents an investigation of great diagnostic reliability. It is based on the interpretation of visual evaluation, roentgenometry and profilography.
The vertebral cavernous hemangioma is described as the number five cause in the etiology of the Andersson lesion (vertebral-discal destruction in ankylosing spondylitis). In one case of a completely stiffened spine, radiographs showed a vertebral hemangioma with a cockade-like appearance instead of the typical coarse-striated osseous structure. Histologic necropsy results were those of a cavernous vertebral hemangioma. The immobile rigid spine, that is, the pathologically disturbed function appears to have a strong influence on the form, structure and pathology.
Information-theoretical considerations demonstrate the uselessness, in terms of understanding and diagnosis, of seven different systems for grading sacroiliitis in ankylosing spondylitis used by German, French, Canadian, Norwegian, Swedish, and Swiss authors. The illustrations prove that it is not possible to differentiate between a normal and abnormal (inflammatory) x-ray of the sacroiliac joints without the application of tomography. A grading system promises diagnostic and communicative success only when based upon tomography results (6 standard sections in adults), and when it takes the "multicolored picture" into consideration ("multicolored picture": no = sacroiliitis stage 0; yes = stage 1; complete bilateral ankylosis: yes = stage 2).
On the basis of a case of radiologically and histologically investigated calcifying periarthropathy in the tendon of the glutaeus medius muscle the histological appearance and the pathogenesis of pain associated with this process is considered. The transformation of tendon tissue into fibrous cartilage is emphasized.
There are significant correlations between the surface of the acetabular roof sclerosis (supercilium acetabuli) in the hip joint on a normal a.p. radiograph and the corresponding surface of cartilage. This correlation can be defined through mathematical formulas and scaled afterwards. These scales are determined on the basis of our clinical experience with the new supercilium acetabuli score. The score is related to the biomechanical situation of the hip joint and describes 3 classes: Class I = optimum, class II = balance, class III = imbalanced correlation between the supercilium acetabuli and the corresponding part of the joint space. For simple measurement of both surfaces, we developed a measuring instrument, the superciliometer, with which it is possible to obtain standardized conclusions describing the functional morphology of the cartilage in the pressure distribution zone of the hip joint, irrespective of whether there are already any visible radiological signs of coxarthrosis or not.
To examine the rate of side effects and the dose dependence of side effects 185 consecutive patients with active rheumatoid arthritis were randomized to receive 15 mg (group A) or 25 mg (group B) methotrexate (MTX) per week and studied prospectively over 12 months. Dose adjustments were performed according to tolerability and efficacy. With 168 patients eligible for evaluation the rate of withdrawal for any reason was 26% in group A and 27% in B. Withdrawal due to side effects occurred in 16% versus 18%, dose reduction due to side effects in 10% versus 9%. The higher dose was associated with a significantly higher rate of gastrointestinal side effects (28% vs. 17%, p < 0.05) and a tendency for more frequent elevations of transaminases. Other side effects were not dose dependent. A significantly higher rate of dose reduction due to improvement (35% versus 10%, p < 0.001), a more rapid decline of morning stiffness, and a higher number of patients reporting marked improvement are evidence in favour of higher therapeutic efficacy of the higher dose. In conclusion, an initial dose of 25 mg MTX/week is not associated with a higher rate of limiting side effects as compared with 15 mg/week. The efficacy of doses up to 25 mg/week should be examined in more detail.
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