Search PubMed⌕ Search

Biomedical subjects

W Davies

Publications and source records attributed to W Davies.

72 records · Page 4Linked to original sources
PubMed1984

Ideal atrial lead positioning to detect retrograde atrial depolarization by digitization and slope analysis of the atrial electrogram.

In 10 patients with intact retrograde (V-A) conduction (mean retrograde conduction time 296 +/- 45 msec), bipolar atrial electrograms were recorded simultaneously from three atrial sites (high right atrium [HRA], low right atrium [LRA], and right atrial appendage [RAA]) during sinus rhythm (anterograde electrogram) and paced ventricular rhythm (retrograde electrogram). Atrial electrograms were digitized and analyzed by a special feature detection program which uses sequential slew-rate changes to discriminate different analogue signals. In all patients, it was possible to distinguish anterograde and retrograde atrial depolarizations using the analogue or digital signal recorded from one and usually two [HRA and RAA] lead sites. Digital signal recognition was machine-based and fully automatic, and could be applied to the prevention of pacemaker-mediated tachycardia if incorporated into future microprocessor-based pulse generators.

Adult↗
PubMed1981

The diagnosis of psychopathy by forensic specialists.

Thirty-four forensic specialists from the Prison Service and elsewhere rated 22 alleged signs of psychopathy in order of importance. Only two respondents did not view psychopathy as a clinical entity. The remainder recognized a large number of diagnostic signs, though with much disagreement about the exact importance of each.

Antisocial Personality Disorder↗
PubMedDate not supplied

Toxicologic lesions associated with two related inhibitors of oxidosqualene cyclase in the dog and mouse.

Two novel hypolipidaemic agents, both members of the aminopyrimidine series, with a mode of action of inhibition of oxidosqualene cyclase (OSC), were administered orally to dogs and mice for 14 and 28 days. Both compounds produced a similar spectrum of pathologic changes. In dogs, the agents produced equatorial single cell necrosis and cataract in the lens (also observed clinically); atrophy, ulceration, and inflammation of the cornea; hyperkeratosis, acanthosis, hair papillary atrophy, and inflammation of the skin; and epithelial degeneration and sperm granuloma in the epididymides. One female dog showed signs of liver toxicity. In mice, severe cataract formation was seen with both compounds, and liver toxicity was produced by one of the compounds. The severity and speed of onset of the cataract formation were very marked. The changes seen were dissimilar to those reported with the most commonly used class of hypolipidaemic agents in the clinic, the hydroxymethyl glutaryl coenzyme A (HMGCoA) reductase inhibitors but were reminiscent of those reported for the hypolipidaemic agent Triparanol. which was predictive of toxicity seen in man.

Administration, Oral↗
PubMedDate not supplied

The extension coat color locus and the loci for blood group O and tyrosine aminotransferase are on pig chromosome 6.

A linkage map of pig chromosome 6 was constructed using a wild pig/Large White intercross pedigree. The map comprises 23 polymorphic loci, and the sex-average map length is approximately 170 cM. The study adds three new genes to the chromosome 6 map: the extension (E) coat color locus, and the blood group O (EAO) and tyrosine aminotransferase (TAT) loci. Segregation at the E locus determined two coat color phenotypes among the F2 animals: wild-type color (El-) and black-spotting (Ep/Ep). The E locus showed close genetic linkage to the most distal marker (S0035) on the short arm of chromosome 6. Comparative coat color genetics as well as comparative mapping strongly suggest that E in pigs encodes the melanocyte-stimulating hormone receptor, as previously shown for the corresponding coat color loci in mouse and cattle. TAT was also mapped to the distal part of 6p, whereas EAO was the most distal marker on 6q. A clear tendency for a higher recombination rate in both terminal regions was observed. A model for the evolution of pig chromosome 6, based on comparative mapping data, is presented.

ABO Blood-Group System↗
PubMedDate not supplied

Increased conversion of arachidonic acid to vasodilator prostanoids in spontaneously hypertensive rats.

1. Vasodepressor responses to intravenous injection of prostacyclin, arachidonic acid, and nitroprusside were examined in anaesthetized, spontaneously hypertensive rats (SHR) of the Okamoto strain, and in their normotensive Wistar-Kyoto (WKY) controls. 2. Depressor responses to prostacyclin and nitroprusside did not differ significantly between the two strains. 3. The vasodepressor effects of arachidonic acid were greater and much more prolonged in SHR than in WKY. In rats treated with indomethacin (2 mg/kg) arachidonic acid induced only transient depressor responses which did not differ significantly between these strains. 4. It is concluded that SHR do not differ from WKY in their sensitivity to prostacyclin but they have enhanced ability to transform exogenous arachidonic acid into vasodilator prostanoids.

Animals↗
PubMedDate not supplied

Token changes.

Explore the source record for details and available documents.

Aggression↗