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Biomedical subjects

W D Ward

Publications and source records attributed to W D Ward.

At least 37 records · Page 2Linked to original sources
PubMed1979

Alteration of oxidative enzymes (LDH and MDH) in perilymph after noise exposure.

Chinchillas were exposed to noise (123 dB, 1/2 h, 700--2800 Hz). The activity of lactate dehydrogenase (LDH) and malate dehydrogenase (MDH) was studied immediately after exposure or 1, 7, 14, 21, or 28 days later. LDH activity in perilymph doubled immediately after exposure, gradually decreasing to control values in about a month. The activity of MDH not only doubled immediately after the exposure but continued to rise for at least another 24 h, reaching a peak value of 3.5 times normal at 24 h. The activity was still 1.6 times normal even after a month of recovery. The enzyme activity of serum and CSF remained within the control range throughout the experimental period except for an initial increase of serum enzyme activity due to anesthetic. The results demonstrate that the morphological changes induced by a noise exposure that is known to produce permanent threshold shift (PTS) are reflected in a significant elevation of oxidative enzymes in perilymph. Possible mechanisms of the elevation of enzymes in perilymph are discussed.

Animals↗
PubMed1978

Categorical perception--phenomenon or epiphenomenon: evidence from experiments in the perception of melodic musical intervals.

Categorical perception was investigated in a series of experiments on the perception of melodic musical intervals (sequential frequency ratios). When procedures equivalent to those typically used in speech-perception experiments were employed, i.e., determination of identification and discrimination functions for stimuli separated by equal physical increments), musical intervals were perceived categorically by trained musicians. When a variable-step-size (adaptive) discrimination procedure was used, evidence of categorical perception (in the form of smaller interval-width DL's for ratios at identification category boundaries than for ratios within categories), although present initially, largely disappeared after subjects had reached asymptotic performance. However, equal-step-size discrimination functions obtained after observers had reached asymptotic performance in the adaptive paradigm were not substantially different from those initially obtained. The results of other experiments imply that this dependence of categorical perception on procedure may be related to differences in stimulus uncertainty between the procedures. An experiment on the perception of melodic intervals by musically untrained observers showed no evidence for the existence of "natural" categories for musical intervals.

Humans↗