Biomedical subjects

W D Thompson

Publications and source records attributed to W D Thompson.

183 records · Page 11Linked to original sources

PubMedDate not supplied

The collagen prolyl hydroxylase activity of hepatocytes and mesenchymal cells isolated from normal and regenerating rat liver.

Prolyl hydroxylase activity has been demonstrated in separate populations of hepatocytes and mesenchymal cells from normal rat liver, the amount in the mesenchymal cell preparation being about twice that found in an equal number of hepatocytes. At the third day after partial hepatectomy, there is a 2- to 3-fold rise in hepatocyte prolyl hydroxylase and a 5-fold rise in the mesenchymal cell enzyme content. Sham operation causes a less striking elevation of prolyl hydroxylase in the mesenchymal cell preparations and has no effect on the hepatocyte enzyme.

Animals↗

PubMedDate not supplied

The mononuclear phagocyte system of the mouse as demonstrated by the immunoperoxidase technique using anti-mouse macrophage antiserum.

With an antibody raised to mouse peritoneal macrophages, it is possible to demonstrate macrophages in various murine tissues using an immunoperoxidase technique. The distribution of these cells is described and illustrated. The antigenic determinant(s) appears to reside on the macrophage surface and this has been confirmed by appropriate electron microscopic studies of stained Kupffer cells. With an antibody to human macrophages, the method may be useful in clinical histopathological practice.

Animals↗

PubMedDate not supplied

Factors associated with risk of stress urinary incontinence in women.

The purpose of this study was to investigate risk factors for stress urinary incontinence. Using a case-control method, 140 women with and without stress urinary incontinence were recruited from three private physician practices and interviewed by telephone. The final sample included 94 cases and 46 controls, with a mean age of 51.5 and 54.3 years, respectively. Having any vaginal birth versus having only cesarean sections was associated with a substantial increase in risk for stress urinary incontinence. Episiotomy or tear during delivery was associated with a 3.78-fold increase in risk, but high parity (four or greater) was not a strong predictor. Having a mother with stress urinary incontinence was associated with a substantial increase in risk. Statistically significant associations were also found for multiple urinary tract infections.

Case-Control Studies↗