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W D Terry

Publications and source records attributed to W D Terry.

87 records · Page 5Linked to original sources
PubMed1968

Human monoclonal gamma G-cryoglobulins with anti-gamma-globulin activity.

Seven human gammaG-myeloma proteins which were also cryoglobulins were studied with respect to their reactivity with gammaG-globulins as well as with regard to their antigenic classification within the gammaG-heavy chain subclasses. Five of the seven cryoglobulins studied were positive in at least two of the three tests used to assay for anti-gamma-globulin activity. One protein was only weakly positive in one test system and another was negative in all test systems. The structures which were recognized by the cryoglobulins were localized to the Fc-fragment. Only primate gammaG-globulins contained these antigenic determinants and in some cases the cryoglobulin appeared to show specificity for one human heavy chain subclass over the others. Antigenic analysis revealed that four of the five cryoglobulins with definite antibody activity belonged to the gammaG3-subclass, the fifth belonged to the gammaG1-subclass. The two cryoglobulins which reacted only weakly or failed to combine with gammaG-globulins were both of the gammaG1-subclass. These findings taken together with the localization of the combining site to the Fab-fragment suggests that many of these cryoglobulins may represent antibodies to gammaG-globulin, and that the cryoprecipitate in these cases represents antigen-antibody complexes of such a nature that they precipitate only in the cold.

Antibodies, Anti-Idiotypic↗
PubMed1966

Antigenic heterogeneity of human immunoglobulin A proteins.

Two types of human IgA myeloma proteins were distinguished by immunochemical tests. Seven of 51 IgA-myeloma proteins contained an an tigenic determinant that was not de tected in the other 44 proteins. The distinctive antigenic site was not dem onstrated on either the heavy or light polypeptide chains.

Animals↗
PubMed1966

Notation for human immunogobulin subclasses.

After consultation between immunologists from a number of countries a nomenclature for human immunoglobulins was proposed in 1964 and was published in the Bulletin of the World Health Organization.(1) However, that proposed scheme of notation, which has already gained wide acceptance, left several specialized areas of nomenclature still to be resolved; one of these was the subclasses of immunoglobulins. Some of the research workers most closely concerned with the problem have now agreed upon a unified scheme for the notation of the human immunoglobulin subclasses, and, in particular, of the immunoglobulin G subclass, for which two different nomenclatorial schemes have been followed in recent years. Their proposals are given below.

Humans↗
PubMed1965

Genetic factors and polypeptide chain subclasses of human immunoglobulin G detected in chimpanzee serums.

The Gm and Inv genetic factors, characteristic antigens of human immunoglobulin G, were detected in chimpanzee serums. All animals tested were Gm(a+, x-, b(l)-, b(2)-, b(3)+, b(4)+). Polymorphism was demonstrated for factors Gm(c), Inv(l), and Inv(b). Three of the subclasses of heavy polypeptide chains and both types of light polypeptide chains that are present in human immunoglobulin G were identified in chimpanzee serums.

Animals↗
PubMed1965

GM and INV factors in subclasses of human IgG.

Human G myeloma (7S gamma(2)-myeloma) proteins were investigated for relationships between Gm and Inv genetic factors and the different antigenic types of heavy polypeptide chains (gamma-chains) and light polypeptide chains. Myeloma proteins were isolated from the sera of 1 Chinese, 60 white and 28 Negro individuals. These 89 proteins were tested for eight Gm factors [Gm(a), Gm(x), Gm(b(2)), Gm(f), Gm(b(1)), Gm(b(3)), Gm(b(4)), and Gm(c)], and two Inv factors [Inv(l) and Inv(b)]. Results of the tests were correlated with the four gamma-chain subclasses (gamma(2a), gamma(2b), gamma(2c) and gamma(2d)) and the two types of light polypeptide chains, kappa-chains (type K or I) and lambda-chains (type L or II) found in human IgG molecules. 1. Gm factors were limited to myeloma proteins with heavy polypeptide chains of the gamma(2b)- and gamma(2c)-subclasses. No Gm factors were detected on gamma(2a)- and gamma(2d)-myeloma proteins or on a "heavy-chain" disease protein of subclass gamma(2d). 2. gamma(2b)-Proteins were positive for at least one Gm factor and were either Gm(a+), Gm(a + x+), or Gm(b(2)+ f+). 3. gamma(2c)-Myeloma proteins, and one gamma(2c)-"heavy-chain" disease protein, were positive for at least one Gm factor and contained various combinations of factors Gm(b(1)), (b(2)), (b(4)), and (c). Myeloma proteins from 3 Negroes were included in this group. 4. Inv factors (l) and (b) were limited to myeloma proteins with kappa-light polypeptide chains. These Inv factors were not detected on proteins with lambda-light polypeptide chains. 5. Most (70 per cent) of the gamma(2b)- and gamma(2c)-proteins with kappa-chains were Inv(l+) or Inv(b+). None of the gamma(2a)- or gamma(2d)-proteins with kappa-chains, however, contained these Inv factors.

Black or African American↗