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Biomedical subjects

W D Steck

Publications and source records attributed to W D Steck.

At least 19 recordsLinked to original sources

Wells' syndrome.

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Cellulitis

Systemic mycoses.

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Bibliographies as Topic

Blastomycosis.

Blastomycosis is an uncommon, sometimes self-healing, sometimes fatal, infectious disease caused by the fungus Blastomyces dermatitidis. Although amphotericin B is still considered the drug of choice, ketoconazole and several other imidazole drugs--miconazole, itraconazole, econazole--have shown promise in the treatment of blastomycosis.

Amphotericin B

Eosinophilic cellulitis associated with urticaria. A report of two cases.

Two patients with the clinical and histopathologic findings of eosinophilic cellulitis are presented. In one patient there was a definite relationship between upper respiratory tract infection and flare-ups of eosinophilic cellulitis. This patient's condition was superimposed on a long history of chronic urticaria. In the other patient a relationship to recurrent sinusitis was possible but not definite. There were no other contributory underlying skin diseases in either patient. Eosinophilic cellulitis is not likely a disease entity as such but, instead, represents a severe urticarial hypersensitivity reaction to various stimuli. Collagen alteration by eosinophil granules results in flame figure formation and a granulomatous response, which may explain the prolonged persistence of the lesions.

Adult

Electrocardiography electrode and hand dermatitis from parachlorometaxylenol.

Parachlorometaxylenol is used as a germicide in many topical products. To our knowledge, this is the first case of dermatitis from parachlorometaxylenol in electrocardiograph electrodes used with cardiac monitors. The patient also had hand eczema from a germicidal soap containing parachlorometaxylenol. In addition, our patient had a cross-reaction to dichlorometaxylenol, a reaction not previously reported.

Aged

Combination therapy for psoriasis. Psoralens plus long-wave ultraviolet radiation with betamethasone valerate.

In the treatment of psoriatic patients with psoralens plus long-wave ultraviolet radiation (PUVA), clearing of psoriatic lesions was obtained more quickly and with smaller doses of ultraviolet light when topically applied corticosteroid therapy was added. Twelve patients with symmetrical plaque-type psoriasis were given PUVA on one side of the body and PUVA plus betamethasone valerate on the other side in a paired comparison study. Ten of the patients had faster clearing of lesions on the side that was treated with PUVA and betamethasone than on the side treated with PUVA alone. The other two patients had equal clearing on both sides. All patients remained clear of lesions during maintenance with PUVA alone for at least five months after steroid therapy was discontinued. Combination therapy may save the patient time, expense, and unnecessary exposure to radiant energy.

Adult

Erythermalgia with vasculitis: a review.

Erythermalgia is a condition of the extremities characterized by redness, increased temperature, and burning pain. A case of erythermalgia and coincident vasculitis of the feet is reported. The literature on the subject is reviewed, and a possible mechanism of pathogenesis is discussed.

Erythromelalgia

Lymphatic complications of manual herpes simplex infection.

In seven patients with typical recurrent herpes simplex of the hand, lymphatic complications, developed in the arm during periods of herpetic activity. Six of the patients presented with lymphangitis and lymphadenitis. In one patient, persistent lymphedema developed in the involved hand and forearm.

Adult

Leukocyte counts and arterial blood gases in nonrenal psoriatic patients treated with extracorporeal devices: Preliminary report.

Four psoriatic patients with normal renal function were treated with RP-6 dialyzers. There was a significant decrease in the leukocyte counts at 5 mins of hemofiltration and it remained the same without rebound leukocytosis at 60 mins. Leukopenia was not accompanied by changes in PaO2 or PaCO2 and thus not accompanied by hypoxemia. C3 values were also unchanged, although a tendency to decrease was noted. Leukopenia and hypoxemia may not be related.

Blood Gas Analysis

Bis(2-ethylhexyl) phthalate levels in nonuremic patients treated with extracorporeal devices.

DEHP levels after treatment were studied in 6 nonuremic psoriatic patients undergoing extracorporeal therapy. Serum DEHP levels at the end of therapy of these patients were significantly lower than that of maintenance hemodialysis patients. DEHP and/or its metabolites were excreted by the normal kidneys, although the excretion of nonmetabolized DEHP by the kidneys was minimal. There was no correlation between serum DEHP levels of these nonuremic patients and the type of artificial kidney used or the mode of therapy employed.

Blood

Telogen effluvium: a clinically useful concept, with traction alopecia as an example.

Telogen effluvium is the excessive loss of normal club hairs. It can be diagnosed simply by microscopic examination of the hairs that are being shed. These hairs have uniform shaft diameter and normally shaped bulbs that contain no pigment. The causes of telogen effluvium are well known and easily distinguishable. They include parturition, febrile illness, surgical operations and anesthesia, anticoagulant drugs, psychi stress, crash diets, and traction. Traction alopecia often produces recognizable patterns of hair loss and can be diagnosed in many cases with reasonable certainty. It is usually not accompanied by inflammatory changes and the prognosis is excellent provided the causative styling practices-braids, rollers, ponytails, etc-are discontinued. Telogen conversion may be caused by interference with papillary blood flow. Since traction alopecia would seem to be reproducible, it may serve as a model for the study of telogen conversion.

Alopecia

Localized scleroderma.

Familial scleroderma is rare; only seven documented instances of the disease have been reported, to our knowledge. This report adds two more families to the literature. Three children in one family and two in the other had clinically and histiologically established localized scleroderma.

Adolescent