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Biomedical subjects

W D Rider

Publications and source records attributed to W D Rider.

At least 73 records · Page 4Linked to original sources
PubMed1978

Radiotherapy of colorectal cancer.

Radiotherapy has an increasingly important place in the management of patients with colorectal cancer. At present the exact indications have not been made based on preliminary experience at the Princess Margaret Hospital, Toronto: 1. Radical irradiation could be a valuable alternative to the classical Miles' abdominoperineal excision of extraperitoneal rectal cancer. 2. Preoperative irradiation may be used for all patients undergoing surgical excision and restoration of bowel continuity. 3. Postoperative radiotherapy can be administrated (a) when the tumour has penetrated the bowel wall to the serosa or beyond, (b) when the lymph nodes are involved secondarily and (c) when the distal line of resection is less than 4.0 cm from the tumour (as measured in the fixed pathological specimen). 4. Radiotherapy is useful for palliation of postsurgical recurrences and symptomatic distant metastases.

Colonic Neoplasms↗
PubMed1978

Carcinoma of the lip--a case presentation.

An unusually advanced case of squamous cell carcinoma of the lip is presented. Case management involved the use of a radiosensitizing agent, radiotherapy, surgical resection, and reconstruction. Two years later the patient is free of disease.

Carcinoma, Squamous Cell↗
PubMed1978

Management of carcinoma of the extrahepatic bile ducts.

The records of 80 cases of carcinoma of the extrahepatic bile ducts were studied. The median duration of survival, in months, of patients who were treated by curative surgery, palliative surgery and radiation, palliative surgery alone and biopsy alone was 21.7, 9.3, 5.5 and 1, respectively. The best results were obtained by excision of the tumour, but only 10% of tumours were considered resectable. A more aggressive surgical approach to tumours still confined to the bile ducts might be expected to increase the resectability rate and improve survival. The use of a U tube is recommended because it ensures greater comfort even though survival is no longer than when a T tube is used. The roles of adjuvant radiotherapy and chemotherapy need further study. Because of some encouraging responses with the use of radiotherapy and the infusion of 5-fluorouracil the authors are currently evaluating these two methods of treatment.

Adenocarcinoma↗
PubMed1977

The incidence of radiation pneumonitis as a result of single fraction upper half body irradiation.

The incidence of radiation pneumonitis was determined in 43 patients following a single fraction half body (UHB) irradiation. Radiographs taken before and at least 4 months after UHB treatment were scored for evidence of pneumonitis. Nine patients received only pulmonary irradiation from the UHB treatment. There was no evidence of radiation pneumonitis in eight for whom there was adequate follow up. From this and other supportive evidence presented in this retrospective study, it is suggested that a total lung irradiation of 800 rads produces no changes that can be seen radiographically, provided there has been no previous major pulmonary irradiation or concurrent malignant pulmonary disease. In patients who received additional mediastinal irradiation, severe changes appeared within this field while mild to moderate radiographic changes were seen outside the mediastinal field.

Breast Neoplasms↗
PubMed1977

Physiological and radiographic assessment during the development of pulmonary radiation fibrosis.

Repeated regional measurements of pulmonary blood flow and ventilation were performed in 25 patients irradiated for breast cancer. Patients were studied before and at varying times after (16 to 47 days) the start of radiotherapy. At the same time, chest radiographs were taken and symptoms recorded. Of all the parameters measured, blood flow showed the earliest and greatest decrease. Since changed in blood flow at 60 days are predictive of the changes at 300 days, we believe that earlier studies during the course of irradiation could be useful in predicting long-term effects.

Breast Neoplasms↗
PubMed1977

Supervoltage irradiation in the management of giant cell tumor of bone.

Thirteen patients with giant cell tumor of bone were treated with megavoltage irradiation from 1958 to 1972. Nine cases were believed to be true giant cell tumors of bone. The only patient with recurrence following a geographic miss was salvaged surgically. Curative therapy for giant cell tumor of bone may be 3500 rads in 15 fractions in 3 weeks; it is well tolerated with minimal morbidity. Special care must be used in interpretation of the post-therapy radiologic appearance of these lesions because an initial period of osteolysis lasts many weeks before any radiographic indication of healing by recalcification occurs.

Adolescent↗
PubMed1977

Preoperative irradiation in operable cancer of the rectum: report of the Toronto trial.

The authors have studied the value of preoperative radiotherapy in 125 patients with cancer of the rectum. The patients were divided into two groups, control (no irradiation) and experimental (irradiation), and according to Dukes' pathological stage. The crude survival indicated no difference between the two groups, but analysis by stage and group demonstrated that for patients with a Dukes' stage C lesion, 500 rads of cobalt-60 gamma irradiation a few hours before excision of the lesion approximately doubles the probability of survival at 5 years. The prospect of surgical cure is three times higher in cancers arising above the peritoneal reflection than in those arising below it. If the practice of abdominoperineal resection is to continue the authors recommend that preoperative irradiation become a routine procedure.

Adenocarcinoma↗
PubMed1976

Radiotherapy in the treatment of recurrent bladder cancer.

A retrospective review of 1,518 cases of transitional cell carcinoma treated by supervoltage irradiation is presented. The majority of patients had recurrent disease after previous treatment. An appreciable salvage rate has been achieved. A "high risk" group for distant metastases has been identified (T3) and the suggestion is made that adjunctive therapy be employed to deal with occult metastases. The place of preoperative irradiation in Stage T2 tumours has been referred to. It is recognised that this is an ageing population. Many die not of their cancer but from other causes. It is difficult to compare these results with others published because of problems in selection and differences in staging the tumours.

Age Factors↗
PubMed1976

Half-body radiotherapy of advanced cancer.

Half-body radiotherapy to deliver doses up to 1000 rads in a single exposure evolved to meet a need in treating patients with advanced cancer. Large fields are required and a high radiation output. Treatments are well tolerated, although radiation sickness occurs in 80% of upper half and 33% of lower half-body treatments. Marrow depression is not a problem and the second half body can be treated when the peripheral blood count has returned to normal. Subjective improvement occurs in most patients and this group had a median survival of six months.

Female↗
PubMed1976

Half-body radiotherapy of advanced cancer.

Half-body radiotherapy to deliver doses up to 1000 rads in a single exposure evolved to meet a need in treating patients with advanced cancer. Large fields are required and a high radiation output. Treatments are well tolerated, although radiation sickness occurs in 80% of upper half and 33% of lower half-body treatments. Marrow depression is not a problem and the second half body can be treated when the peripheral blood count has returned to normal. Subjective improvement occurs in most patients and this group had a median survival of six months.

Female↗