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Biomedical subjects

W D Linscott

Publications and source records attributed to W D Linscott.

30 records · Page 2Linked to original sources
PubMed1969

Complement components required for virus neutralization by early immunoglobulin antibody.

Virus neutralization by early antisera usually requires or is enhanced by the presence of complement. The particular components of the complement system which are needed for neutralization of Newcastle disease virus by early IgM antibodies were studied. It was found in this system that participation of only the first four of the nine complement components (C1, C2, C3, and C4) was necessary and sufficient for neutralization to occur. It was concluded that the role of complement in neutralization was most likely that of contributing bulk in the form of large protein molecules to the virus-antibody complex.

Animals↗
PubMed1968

Human monocytes: distinct receptor sites for the third component of complement and for immunoglobulin G.

Human monocytes contain two distinct receptor sites, one specific for the third component of complement (C'3), the other for immunoglobulin G(gammaG). The two receptors may function either independently or cooperatively in the induction of phagocytosis. Ingestion of erythrocytes coated with immunoglobulin M antibody requires a relatively large number of bound C'3 molecules per cell. Ingestion of erythrocytes sensitized with gammaG antibody is independent of complement; however, the reaction is inhibited by concentrations of gammaG far below those in normal serum. Inhibition by gammaG-globulin is overcome by a relatively small number of bound C'3 molecules per cell. The two monocyte receptors exert a cooperative effect on ingestion by monocytes of erythrocytes coated with gammaG antibody in the presence of inhibitory amounts of free gammaG.

Antibodies↗