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Biomedical subjects

W D Keidel

Publications and source records attributed to W D Keidel.

At least 19 recordsLinked to original sources
PubMed1992

[The phenomenon of hearing: an interdisciplinary discourse. I].

For the last century hearing has been considered a purely passive process. G. S. Ohm's and H. v. Helmholtz's resonance theory of hearing was widely accepted until Wien's fundamental objection led to G. v. Békésy's and O. F. Ranke's travelling wave theory, the hydrodynamics of the inner ear that distributes the frequencies along the basilar membrane, which acts as the "first filter". Seebeck, Licklider, Schouten, and deBoer emphasized also the time domain and developed the concept of periodicity hearing and the "residue phenomenon". However, it was not until the concept of the "cochlear amplifier" and "active hearing" with energy generation during the transduction process within the ear itself was introduced that the "second filter" could be understood. Kemp's echo was the key to this revolutionary step in the theory of hearing.

Auditory Perception↗
PubMed1992

[The phenomenon of hearing: an interdisciplinary discussion. II].

This part of the paper deals with the neurophysiological background of speech analysis and hearing of music. Single vowel- and consonant-detector cells could be clearly separated at the colliculus and geniculate level (Kallert, Keidel). Musical stimulation is decoded at three levels: hair cells, geniculate, and auditory cortex. Human cortical evoked potentials represent rhythm, consonance, and (as DC-shift) the emotional content of music. Marked harmonics, even of single hair-cell vibrations and in single units of medial geniculate in combination with clock-cell networks, are the physiological basis of "harmony" in music. Dissonant stimuli are detectable at the cortical level in man (Finkenzeller, Keidel).

Auditory Cortex↗
PubMed1989

The computer-vibromyography as a biometric progress in studying muscle function.

Muscular vibrations were recorded from different relaxed and contracted skeletal muscles in human subjects, with the use of a piezo-electric device. Simultaneous wire-EMG recordings were performed. Spectral analysis of the acceleration curves (vibromyograms) disclosed muscle and function dependent compound frequency patterns. We suggest that the activity of motor units including the action of central reflex loops and oscillatory driving is mainly responsible for the muscular vibrations. Other sources are discussed. Computer-Vibromyography as a mechanical ensemble measurement supplements bioelectric EMG techniques and classical tremor analysis and provides further insights into the function of muscle and motor-system.

Adult↗
PubMed1984

[Determination of two unknown peaks in the 31P magnetic resonance spectrum appearing during the breakdown of high energy phosphates in the ischemic heart and skeletal musculature].

Using the 31-Phosphorus pulsed NMR-technique by FFT information processing it was possible to obtain the following results: The phosphorus compounds were measured as time function in the course of 24 h in isolated skeletal and cardiac muscle of rana temporaria in a dynamic NMR experiment. The shift of the observed resonance lines by increasing intracellular H+ concentration during anoxic conditions will be described in this paper in accordance with the NMR literature. The time course of the beta group of ATP (which is representative for ATP) has been found not to decrease monotonically but rather periodically in a half-hour periodicity until finally a complete fading of ATP in the NMR spectrogram occurs. Besides the resonances described in the literature it was possible to record two additional unknown resonance lines 1.6 and 4.6 ppm apart from the classical alpha- and beta ATP peaks. The peak area of this up to now unknown substance followed a periodic law, regarding the first 2-3 h after preparation. Afterward the concentration dropped to zero. Some shift of the resonance lines of the NMR spectrum could be observed dependent upon the fact that in the muscle cell the ATP normally occurs as a complex with Mg++ ions (MgATP). After separation of Mg++ ions from ATP at low intracellular pH values the resonance lines shifted by some 1-4 ppm. This was tested by test solutions containing MgATP as a complex of free ATP. Although this observation could not sufficiently explain the two as yet unknown lines in the NMR spectra, this result gave rise to further exploration of the phenomenon. To explain the unknown resonance lines, the spectra of the heart and skeletal muscle were compared with that of an adenosine tetraphosphate solution. Based upon the fact that the frequencies of the lines under discussion are identical with those of the adenosine tetraphosphate, one can conclude with a high degree of probability that the as yet unknown lines are originated by adenosine tetraphosphate. If this hypothesis is correct, the concentration of adenosine tetraphosphate could be determined in the order of 1 mM, thus being one third or one quarter of the concentration of the adenosine triphosphate. To give better evidence for the clarification of the newly found substance it will be necessary to record under identical experimental conditions 1H and 13C NMR spectra during the time course of deterioration of the skeletal and cardiac muscle.(ABSTRACT TRUNCATED AT 400 WORDS)

Adenosine Triphosphate↗
PubMed1980

Late cortical-evoked responses in clinical use.

Direct-current (dc) deflections in the EEG in response to sensory stimuli were first described by Köhler who, however, employed relatively high intensities. Gumnit, as well as Caspers, working with physiological stimulus intensities in animals, and recording from the primary projection areas of the different sensory modalities then showed that the evoked dc potentials during stimulation were restricted to a relatively small area of the animal's cortex which conformed well to the locus of the chosen modality. In our laboratory, using a fully computerized dc recording averaging system with Beckman electrodes, placed normally on the vertex, we have developed a routine technique adapted for clinical use. By this means, all types of electric responses obtainable from the intact human skull so auditory, gustatory and olfactory stimuli can be plotted simultaneously including the dc shift duirng a relatively long-lasting train of clicks (perstimulatory dc shift). This technique has been applied both in normal and in pathological subjects in various hospitals (ENT and children's clinics, in our country. The results obtained using this technique are described in our contribution.

Adult↗
PubMed1980

Neurophysiological requirements for implanted cochlear prostheses.

In a few introductory remarks the technological, neurophysiological and clinical assessments of new developments in modern, highly sophisticated hearing aids are reviewed. The necessity of preprocessing auditory information is discussed as well as the problems related to the choice of suitable electrodes, and, in particular, how much auditory information for speech communication, given by the product of number of just noticeable differences in intensity, number of just noticeable differences in frequency, number of channels for conveying neurophysiologically processable signals would be required as a minimum for cochlear implants to enable patients to communicate with one another. Finally, the fact that a number of different sensory modalities converge in to man's cortical association area might possibly be used for some special application of a multimodal input in a completely deaf patient with the aim of enabling him to understand human speech.

Animals↗
PubMed1976

[The significance of the CNS for the physiology of hearing (author's transl)].

Some general aspects of auditory perception (funnelling, contrast, pattern recognition, form perception, methodological limitations) are discussed in the first part of this presentation. The modern concept of the hydrodynamics of the inner ear, including electronic modelling of the function of the basilar membrane is their dealth with. For the encoding and decoding processes of the auditory system the different grades of intensity function at the different neuronal levels is compared with that of the envelope of the basilar membranes deflection. The influence of the efferent system is discussed. In a third section of the paper some new results from our department are reported concerning the single unit activity at geniculate level recorded from the awake cat by means of a telemetric system. Neurophysiological correlates to vowel- and consonant detectors and their relations to be the phonem recognition of speech could be demonstrated. Finally, the most recent state of objective audiometry is discussed (DC-potentials, simultaneous records of electrocochleogram and cortically evoked activity, relations to EEG's power spectrum, and brains changes in vigilance) with a view of future approaches to ERA.

Animals↗