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Biomedical subjects

W D Glenn

Publications and source records attributed to W D Glenn.

9 recordsLinked to original sources
PubMed1990

Methylation of an immediate-early inducible gene as a mechanism for B cell tolerance induction.

Stage-specific gene regulation is important in determining cell function during development. Immature B cells expressing membrane-bound immunoglobulin M (mIgM) are sensitive to antigen-induced tolerance, whereas mature B cells are activated by antigen. Previous studies have established an association between Egr-1 gene induction and antigen receptor (mIgM)-mediated activation of mature B cells. Here it is shown that the immature B cell line WEHI-231 and tolerance-sensitive bone marrow-derived B cells do not express Egr-1. It is further shown that lack of inducible expression in these cells is due to specific methylation of the Egr-1 gene. Thus, covalent inactivation of an activation-associated gene may explain tolerance sensitivity at specific stages of B cell development.

Animals↗
PubMed1985

Some physico-chemical properties of deciduous enamel of children with and without pre-natal fluoride supplementation (PNF).

Physico-chemical investigations of enamel from deciduous teeth of a small number of children with and without pre-natal fluoride supplementation (PNF) exhibited the following differences between the PNF and non-PNF enamel, with the former showing: (a) more homogeneous and less extensive patterns of acid-etching; (b) denser crystal populations in intra-prismatic regions; (c) larger prism dimensions; (d) greater total mineral density (wt%ash); (e) higher degree of crystallinity; (f) smaller a-axis dimensions; and (g) more fluoride and less carbonate contents. On the basis of these preliminary findings, further studies with larger numbers of samples would seem appropriate.

Carbonates↗
PubMed1982

Fluoride tablet supplementation during pregnancy for caries immunity: a study of the offspring produced.

Evidence continues to accumulate that the fetal nutritional need for the mineral fluoride begins early in pregnancy and that tablet supplementation is required during the last two trimesters to supply that need, since fluoridated water alone during pregnancy is not sufficient. This study of 492 children confirms the safety and efficacy of using a sodium fluoride tablet supplement, by means of which the obstetrician can help his pregnant patients produce children with superior teeth that are immune to decay.

Administration, Oral↗
PubMed1972

Malpractice laws.

Explore the source record for details and available documents.

Age Factors↗
PubMedDate not supplied

Optimum dosage for prenatal fluoride supplementation (PNF): Part IX.

There exists such a wide margin of safety for prenatal fluoride in regard to fluorosis that 2 mg/day can be used as a simplified prenatal fluoride dosage in all areas, regardless of whether they are fluoridated. Any prenatal fluoride dosage between 1 and 4 mg/day is better than no prenatal fluoride at all.

Dental Caries↗
PubMedDate not supplied

Prenatal fluoride tablet supplementation and improved molar occlusal morphology: part V.

This article is a report of an in vivo clinical study in which the relationship of sodium fluoride supplementation during pregnancy to the improved occlusal morphology of molar teeth seen in an animal model was determined. Two hundred randomly selected children composed the study population. The mothers of 100 of them had been on the prenatal supplementation (PNF) regimen and 100 whose mothers were not were found to have statistically significant differences in their occlusal molar morphology. Ninety-eight percent of the PNF children have a smooth, naturally sealed appearance to the occlusal surfaces of their primary molars and permanent first molars. The authors conclude that pitted and fissured molars are produced as a result of fluoride deficiency during the secretory phase of crown formation.

Child↗