Search PubMed⌕ Search

Biomedical subjects

W D Dawson

Publications and source records attributed to W D Dawson.

At least 37 records · Page 2Linked to original sources
PubMed1979

Retinyl acetate prophylaxis in cancer of the urinary bladder.

Virgin female C3H/He mice (275) were fed a ration that included 0.1 per cent N-4-(5-nitro-2-furyl)-2-thiazolyl formamide (FANFT) and retinyl acetate. The mice were divided into five groups with Groups 1 through 4 receiving 300, 600, 1200, and 2400 IU of retinyl acetate per kilogram of feed plus FANFT respectively. Group 5 received 300 IU per kg of feed and no FANFT as a control. After 45 weeks the bladders were removed and inspected for neoplasms. There were no tumors found in any of the mice from Group 5. It was found that retinyl acetate significantly inhibited the formation of squamous cell tumors at all levels and inhibited transitional cell carcinoma when given as 600 IU per kilogram of feed.

Animal Feed↗
PubMed1976

Genetic and developmental variation of hemoglobin in the deermouse, Peromyscus maniculatus.

A genetic investigation of electrophoretic hemoglobin variants of the deermouse, Peromyscus maniculatus, shows three alleles, Hblf, Hblr, and Hblo, at a duplicated site controlling the six adult phenotypes. The Hblf allele has not been described previously. The hemoglobin locus is not closely linked to the albino locus. Fetal hemoglobin is distinct from any of the adult components and has a slower electrophoretic mobility. The fetal phenotype changes to the adult type between the days 15 and 18 of prenatal life.

Alleles↗
PubMedDate not supplied

Coat color genetics of Peromyscus: V. California blonde, a new recessive mutation in the deer mouse.

California blonde is a coat color mutation in the deer mouse (Peromyscus maniculatus) discovered among descendants of wild-type animals collected on Santa Cruz Island, California. The phenotype is produced by the presence of brown, rather than black, eumelanin in the pelage and skin. Retinal pigmentation is also reduced. The condition is inherited as an autosomal recessive trait. The California blonde gene is nonallelic with the brown (b), blonde (bln), and platinum (plt) mutant genes in this species. California blonde represents a newly detected genetic locus in the deer mouse. The symbol cfb is provisionally assigned for this genetic locus.

Animals↗
PubMedDate not supplied

Genetic variation of amylases in deer mice.

The inheritance of salivary amylase variants in the deer mouse, Peromyscus maniculatus, is controlled by codominant alleles, Amy-1a, Amy-1b, and Amy-1c, at a single autosomal locus. Pancreatic amylases were invariant and unaffected by salivary amylase genotypes. Salivary amylase zymograms of five myomorphic rodents are compared and evolutionary implications are discussed.

Amylases↗
PubMedDate not supplied

Platinum coat color locus in the deer mouse.

Platinum coat color in the deer mouse, Peromyscus maniculatus, is an autosomal recessive trait marking a locus, pt, distinct from silver (si), albino (c), blonde (bl), brown (b), and agouti (a). Platinum deer mice are conspicuously pale, with light ears and tail stripe. The pewter trait is allelic with and phenotypically identical to platinum, and represents an independent recurrence of this mutant. The rate of recoveries of coat color mutations from wild deer mice is consistent with available data for recurring mutation rates balanced by strong selection against the recessive phenotype.

Alleles↗
PubMedDate not supplied

Coat color genetics of Peromyscus. I. Ashiness, an age-dependent coat color mutation in the deer mouse.

Ashy deer mice (Peromyscus maniculatus) were first discovered about 1960 in a wild population from Oregon. Although indistinguishable from the wild type at weaning, ashy deer mice become progressively grayer with subsequent molts. The trait is inherited as an autosomal recessive and the symbol ahy is assigned for the locus. The trait is distinctly manifest by 6 months of age, at which time homozygotes have white hairs on the muzzle and at the base of the tail. The amount of white gradually increases with age, but development varies greatly among animals. Some become virtually all white by 18 months. Implants of melanocyte-stimulating hormone induced production of pigment in depigmented portions of the coat, indicating that viable melanocytes were present. The ashy deer mouse model may be useful for further study of melanocyte function.

Aging↗
PubMedDate not supplied

Morphological analysis of hair in the hr-2 mutant deer mouse (Peromyscus maniculatus).

Skin from 36 hairless deer mice (Peromyscus maniculatus) homozygous for the recessive hr-2 mutation were analyzed for structural defects in hair and hair loss. Comparison of mutant to wild-type hairs demonstrated characteristic abnormalities in cellular organization, hair shape, length, and fragility. Matings between mutants homozygous for the hr-2 gene and for a second mutation producing hairlessness in deer mice, hr-1, showed that these two genes were nonallelic. Structural abnormalities in hairs associated with the expression of this gene suggest that its primary effect may be on the epidermis.

Alopecia↗
PubMedDate not supplied

Coat color genetics of Peromyscus: II. Tan streak--a new recessive mutation in the deer mouse, P. maniculatus.

The first mutant tan streak deer mice appeared in the initial laboratory-bred generation of a stock of Peromyscus maniculatus nubiterrae collected in Macon County, North Carolina. Laboratory progeny from the original animals were bred and mated among themselves and to wild-type individuals. The tan streak phenotype is characterized by nearly complete absence of coat pigmentation, except for a pale tan patch or narrow stripe extending mid-dorsally posteriorly from the head. The band is frequently somewhat broader in the shoulder region, occasionally forming a cross-shaped pattern. There is no evidence of black eumelanin in any part of the coat. The eyes are fully pigmented, appearing black, and pigment is present in the skin of the ears and elsewhere. The trait is inherited as an autosomal recessive. The genetic locus is provisionally designated tns. Crosses between homozygous tan streak (tns/tns) animals and albino (c/c), ivory (i/i), non-agouti (a/a) and brown (b/b) deer mice produced only wild-type progeny, indicating that the tns mutation is not at any of these loci.

Alleles↗