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Biomedical subjects

W D Cubitt

Publications and source records attributed to W D Cubitt.

64 records · Page 4Linked to original sources
PubMed1983

Epidemic of gastroenteritis caused by oysters contaminated with small round structured viruses.

A large outbreak of viral gastroenteritis occurred in which oysters eaten raw were the vehicle of infection. Laboratory findings indicated that a small round structured virus was the infecting agent. Adults of all ages were equally susceptible to infection with the virus. Investigation cast doubt on the efficacy of depuration as a method for rendering oysters free of virus, and hence the public should be warned of the hazard of eating raw shellfish.

Adult↗
PubMed1983

Improved immunofluorescence techniques with microplates for the detection of M and G immunoglobulins against rotavirus.

A selection of microplates and an inverted microscope were used for the detection of immuno-fluorescence in large numbers of infected cell monolayers. The optical features of this instrument in combination with either Terasaki or Microlymp plates, simplify procedures and allow economical use of reagents, for determining fluorescent antibody levels. The techniques described were applied for estimating M and G immunoglobulins against rotavirus in elderly patients and the validity of the tests was established.

Antibodies, Viral↗
PubMed1981

A comparison of the efficiency of human embryo intestine, Hep 2 cells, and human embryo kidney cells for the primary isolation of ophthalmic viruses.

A comparison has been made of the efficiency of 3 cell systems, human embryo kidney (HEK), Hep 2, and a continuous line of human embryo intestine (HEI), for the isolation of ophthalmic viruses. A total of 40 herpes simplex, 51 adenoviruses, and 2 vaccinia viruses were isolated from 323 specimens. HEK cells were found to be the optimal system, 85 out of 93 (91%) of the viruses being detected in these cells alone. However, HEK cells are difficult to obtain, and therefore the use of a combination of the continuous cell lines HEI and Hep 2 is recommended as an alternative. 89% of the viruses were detected by this combination. The use of either HEI or Hep 2 cells alone was unsatisfactory.

Adenoviruses, Human↗
PubMed1980

An outbreak of calicivirus infection in a mother and baby unit.

A small outbreak of infection due to a calicivirus occurred in a mother and baby unit. All the infants showed evidence of infection but the clinical features varied. None of the staff or mothers showed evidence of illness, and antibody studies indicated past experience of this virus.

Adult↗
PubMed1980

An outbreak of rotavirus infection in a long-stay ward of a geriatric hospital.

An outbreak of rotavirus infection in elderly patients in a long-stay ward of a geriatric hospital is described. Virus was detected in 7/15 (47%) symptomatic individuals. Four members of staff were among those affected. The findings emphasise the need for electron microscopy to be used in the initial investigation of outbreaks of diarrhoea in all age groups.

Adult↗
PubMed1979

Winter vomiting disease caused by calicivirus.

The clinical, epidemiological, and virological features of an outbreak of winter vomiting disease among London schoolchildren are described. Evidence is presented to support the view that this epidemic was caused by a human calicivirus, a virus not previously shown to be associated with this disease in man.

Caliciviridae↗