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Biomedical subjects

W Cooley

Publications and source records attributed to W Cooley.

5 recordsLinked to original sources

Carbon dioxide-insufflated colonoscopy: an ignored superior technique.

Colonoscopy and barium enema are complementary studies in the diagnosis of the cause of lower intestinal bleeding. The air usually insufflated during colonoscopy often makes it impossible to perform a good barium enema on the same day. As a possible solution to this problem, we studied the quality of barium enemas performed immediately following carbon dioxide-insufflated colonoscopy. All 15 patients who underwent unsuccessful total colonoscopies using carbon dioxide insufflation were able to have barium enemas performed the same day in contrast to only one out of 15 patients who had air-insufflated colonoscopy. In a survey of all hospitals in Illinois with 150 beds or more, we found only 15 of 146 hospitals used carbon dioxide for colonoscopy insufflation. We recommend the routine use of carbon dioxide for colonoscopic insufflation not only for greater safety and comfort for the patient, but also for the convenience and cost savings.

Adult

Facilitating change.

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Continuity of Patient Care

The health care needs of women veterans.

Although women veterans accounted for 4.1 percent of all veterans in 1983, they accounted for only 1.5 percent of all discharges from Veterans Administration hospitals in that year. These data suggest that women veterans are not utilizing their health care benefits as often as male veterans do, possibly because they are choosing to receive health care in non-VA facilities. Furthermore, the patterns of utilization for women veterans suggest a selective use of VA hospitals for serious illnesses that require protracted care. The author explores some possible explanations for this phenomenon and emphasizes the need for the VA health care system to incorporate such information in the planning of health care services for women veterans.

Adult

A new gene of Escherichia coli K-12 whose product participates in T4 bacteriophage late gene expression: interaction of lit with the T4-induced polynucleotide 5'-kinase 3'-phosphatase.

We isolated five Escherichia coli mutants deficient in their ability to support the late (replication-coupled) gene expression of T4 bacteriophage at 30 degrees C. These mutants, which we call Lit mutants, define at least one novel gene at 25 min on the E. coli map. They were selected in an attempt to obtain mutants which restrict the growth of T4 mutants deficient in polynucleotide 5'-kinase 3'-phosphatase but not that of wild-type T4 at 37 degrees C. Some of the mutants do have these phenotypes under some conditions. Studies of the block in T4 development in some of the E. coli mutants suggest that Lit mutants are affected in a gene product involved in the metabolism of deoxyribonucleic acid nicks or single-strand gaps. None of the Lit mutants is deficient in the major, bacterial, 3'-phosphatase activity in crude extracts.

Chromosome Mapping