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W Coleman

Publications and source records attributed to W Coleman.

35 records · Page 2Linked to original sources
PubMed1977

[Not Available].

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Demography↗
PubMed1975

Regulation of branched-chain aminoacyl-transfer ribonucleic acid synthetases in an ilvDAC deletion strain of Escherichia coli K-12.

Valyl-, isoleucyl-, and leucyl-transfer ribonucleic acid synthetase formation was compared in isogenic strains of Escherichia coli K-12 that differed only in that one strain carried a deletion of three genes of the ilv gene cluster, ilvD, -A, and -C. It was found that: (i) the activities of these synthetases in the deletion strain were less than those in the normal strain during growth in minimal medium supplemented with excess isoleucine, valine, and leucine, and (ii) their stability was reduced in the deletion strain during specific branched-chain amino acid limitations. The results of density-labeling experiments suggest that the in vivo stability of valyl-, isoleucyl-, and leucyl-transfer ribonucleic acid synthetases requires some product missing in the ilvDAC deletion strain.

Amino Acyl-tRNA Synthetases↗
PubMedDate not supplied

Complicated surgical techniques. I. Flaps and grafts.

Most defects in dermatologic surgery can be repaired by primary closure. If this is not feasible, then local flaps should be employed. Where flaps are unfeasible or would result in an additional cosmetic deformity, then a full-thickness skin graft should be employed. If the defect is too large for a full-thickness skin graft, then a split-thickness skin graft is the appropriate choice. Individual surgical situations or the medical status of the patient may alter these general principles.

Humans↗
PubMedDate not supplied

Hemodynamic actions of a synthetic atrial natriuretic factor.

The recently discovered atrial natriuretic factor (ANF), as well as synthetic ANF, has been demonstrated to produce diuresis and vasodilation. However, the vascular actions appear to be selective. In view of this apparent relative specificity, the hemodynamic actions of synthetic ANF (atriopeptin II, 23 amino acid rat sequence) were examined in intact animals and in vascular beds as well as in isolated cardiac preparations. Administration of 1-100 micrograms/kg of ANF i.v. into conscious spontaneously hypertensive rats (SHRs) resulted in a dose-related fall in blood pressure. Heart rate decreased at the lowest dose. Cardiac output was depressed. Infusion of 1 microgram/kg/min also reduced blood pressure and decreased cardiac output slightly (approximately 15%). Intraarterial (i.a.) administration or i.v. injection of ANF into the blood supply of a kidney of anesthetized SHRs augmented renal blood flow and reduced renal vascular resistance. In contrast, i.a. administration into the hindquarters failed to increase blood flow or decrease resistance of this bed significantly. The specific dopamine1 (DA1)-receptor agonist SKF 82526 was examined for comparative purposes and was found to augment both renal and hindquarter blood flow following i.a. administration. The renal vasodilator actions of SKF 82526 but not ANF were antagonized by the specific DA1-receptor blocker SCH 23390 (hindquarter effects were not evaluated). ANF did not affect the force of contraction or rate of beating of isolated guinea pig atria or isolated hearts and therefore does not appear to possess direct inotropic or chronotropic properties. In conclusion, ANF lowered blood pressure in conscious SHRs; the lowering of pressure was accompanied by a slight fall in cardiac output, but there was no reflex tachycardia.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMedDate not supplied

Plantar space abscesses in the diabetic foot: diagnosis and treatment.

Plantar space abscesses in the diabetic foot are relatively uncommon. These abscesses are an anatomic type of foot infection. Three plantar spaces have been identified: the medial, central, and lateral. The central plantar space is by far the most important. Within the central plantar space are tendons of the flexor digitorum longus, flexor digitorum brevis, quadratus plantae, lumbricales pedes, the medial and lateral plantar nerves, and the plantar arterial arch. Located within the lateral and medial spaces are the short flexor and abductor muscles to the first and fifth rays. Plantar space infections may arise from a variety of causes. Infections of the fibrofatty tissue of the toe pad or the long flexor tendon sheaths and lumbrical tendons secondary to web space infections, poor nail care, trauma, and mal perforans ulcers have been implicated. A medial incision is recommended for drainage of both the medial and central plantar spaces. This avoids a painful plantar scar and allows for extensive incision and drainage of these abscesses. The lateral plantar space is best drained by a lateral incision. Both incisions heal without a sensitive scar. Control of sepsis is of primary importance. If left uncontrolled, obliteration of the plantar arterial arch occurs. Necrosis of the distal foot and central three toes results, thereby preventing any effort to save the diabetic foot.

Abscess↗