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Biomedical subjects

W Check

Publications and source records attributed to W Check.

At least 55 records · Page 3Linked to original sources
PubMed1994

Thyroglossal duct carcinoma.

The thyroid gland originates from the foramen cecum, and by 7 weeks gestation, descends ventrally in the midline of the neck. During its descent, a patent diverticulum, the thyroglossal duct, connects the gland to the base of the tongue. While the duct normally closes by the tenth gestational week, it is not uncommon to have all or a portion of the duct remain patent as a thyroglossal duct cyst or sinus. While these cysts are relatively common, thyroglossal duct carcinomas are very uncommon. They are generally of two types: squamous cell carcinoma arising from metaplastic columnar cells, and thyrogenic carcinoma arising from thyroembryonic rests in the duct or cyst. We report one case of each. The squamous cell carcinoma was resected via the Sistrunk procedure with no evidence of recurrence over a 10-year follow-up. The thyrogenic carcinoma (papillary type) was resected via the Sistrunk procedure with subsequent total thyroidectomy.

Adenocarcinoma, Papillary↗
PubMed1993

Primary hyperparathyroidism secondary to parathyroid carcinoma: report of a case.

Distinguishing parathyroid carcinoma from benign hyperparathyroidism is often difficult. Clinical features most commonly associated with parathyroid carcinoma, such as palpable cervical mass, markedly higher serum calcium, high parathyroid hormone immunoassay, and evidence of bone disease may not be present. Therefore, intraoperative recognition is essential. We report a case in which the presenting symptoms, physical examination, and laboratory analysis were consistent with benign disease. During surgery, the finding of an enlarged firm gland with surrounding inflammatory reaction altered the approach to include the possibility of parathyroid carcinoma. The gland and surrounding tissue were removed, and pathologic examination led to the diagnosis of carcinoma. At 18-month follow-up, the patient was free from recurrence. Any parathyroid gland with a gray appearance, firm texture, and surrounding inflammatory reaction should be treated as carcinoma. Initial intraoperative recognition offers the best chance for cure, since local recurrences are rarely curable.

Carcinoma↗