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Biomedical subjects

W Cendrowski

Publications and source records attributed to W Cendrowski.

At least 163 records · Page 9Linked to original sources
PubMedDate not supplied

[Prophylactic use of penicillin G and ampicillin in stroke. I. Clinical observations].

In 103 patients with strokes without associated infections the prophylactic usefulness of antibiotics was assessed clinically. In 30 patients (group I) and 27 patients (group II) ampicillin was used in daily doses of 2-4 g or penicillin (Polfa) was given 2.4-4.8 million i.u. during 10 days. In the remaining 46 cases (group III) no antibiotics were given and these patients served as controls. During the first 10 days after stroke onset infectious complications developed significantly less frequently in controls (in 15 cases, i.e. 33%) than in those receiving antibiotic phophylaxis (40 cases i.e. 70%). The difference between the groups was statistically significant (p less than 0.001). In the second ten-day period no clinical evidence of new infection was observed in any group. It may be supposed in the light of these diseases that administration of penicillin G or ampicillin to patients with strokes without carrying out antibiotic sensitivity tests is unnecessary. Nearly exclusively pneumonia and urinary tract infection appear in the first ten days after stroke onset which may suggest acute and gradually levelling-off of the neuroregulation of immunological defense mechanisms.

Aged↗
PubMedDate not supplied

[Cerebrospinal fluid prostaglandins in multiple sclerosis. Preliminary report].

In 14 patients with multiple sclerosis exacerbations, in 7 with slowly progressive or stationary disease, and 5 patients with intervertebral disc prolapse the levels of total prostaglandins (PGs) were determined in the cerebrospinal fluid. The determinations were done by bioassay according to Ferreira and Vane. In multiple sclerosis patients the level of total PGs was significantly higher in the cerebrospinal fluid (286 +/- 20.3 pg/ml) than in patients with disc prolapse (142 +/- 7.7 pg/ml) (p less than 0.01). This rise in this level might be due to increased synthesis of PGs by activated macrophages, lymphocytes and neutrophils or to increased hypothalamic response to stress.

Adult↗
PubMedDate not supplied

[Effect of short-term administration of sunflower oil on the blood serum level of linoleic and arachidonic acids and lipids in multiple sclerosis].

Patients with multiple sclerosis had an oral load of sunflower seed oil in daily doses of 40 g during five days. This daily doses contained 27 g of linoleic acid (LA). Prior and after diet supplementation with sunflower seed oil the levels of linoleic and arachidonic acids were determined in the serum of patients. The values were expressed as relative percentages of total fatty acids. Before addition of sunflower oil to the diet the serum levels of linoleic acid (LA) and arachidonic acid (AA) were in these patients significantly lower than in controls amounting to 17.0% and 1.05% (p less than 0.001). After addition of sunflower oil the levels of LA and AA rose to 32.7% and 3.02%. The concentration of total lipids and non-esterified fatty acids in the serum increased also significantly after addition of sunflower oil. Determinations of LA and AA 10 days after withdrawal of sunflower oil showed that their levels were 23.7% and 1.95% respectively. In 2 patients addition of sunflower oil only slightly changed the very low serum LA level. These results indicate that LA and AA deficiency in patients with multiple sclerosis has the character of a non-specific dietary deficiency mainly, although the role of genetic factors controlling the levels of polyunsaturated fatty acids cannot be ruled out.

Adult↗