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Biomedical subjects

W Cendrowski

Publications and source records attributed to W Cendrowski.

At least 19 recordsLinked to original sources
PubMed1991

[Diagnosis and etiopathogenesis of retinitis in patients with multiple sclerosis].

Presented are: the incidence, symptomatology and diagnostics together with electroretinography of retinal periphlebitis as well as retinitis and maculopathy in patients with multiple sclerosis. Particular attention is called to the histopathology of the retina in this disease. The etiopathology of retinitis and maculopathy in multiple sclerosis is still unknown. Four etiopathological hypotheses are shortly discussed.

Electroretinography↗
PubMed1990

Temporary chromatopsia and alternate umbropsia in multiple sclerosis.

Uncommon visual symptoms were described in two women with clinically definite, remittent multiple sclerosis. In the first case with right optic atrophy temporary chromatopsia (vision of only blue colour) and left-sided, paroxysmal and alternate "fading out" followed by "brightening up" vision (umbropsia) occurred spontaneously. In the second case with bilateral optic atrophy transient chromatopsia (vision of only green colour) and short-lived "fading out" vision when fixating on a target were noted. Chromatopsia might be associated with impaired function of selected optic nerve fibers conducting impulses from a limited population of retinal ganglion cells. Alternate umbropsia and short-lived "fading out" vision probably depend on paroxysmal, frequency-related intermittent conduction block at the level of optic nerve fibers or synaptic elements.

Adolescent↗
PubMed1989

[Free fatty acids in the serum of patients with alcoholism].

Blood free fatty acids and their composition were investigated in 25 alcohol abusers hospitalized for detoxication. Blood samples were collected at the admission to the hospital and following detoxication therapy. Free fatty acids were assayed with Dole's technique whereas their composition with gas chromatography. Liver functioning was evaluated with the aid of the following tests: AspAT, AlAT, AP, bilirubin concentration, and thymol test. An increase in free fatty acids concentration was seen in 12 out of 25 patients prior to detoxication. Blood serum free fatty acids were within normal limits in all except one patient after detoxication. A decrease in linoleic acid levels was seen in both total fatty acids and free fatty acids before detoxication. It is more marked in total fatty acids than in free fatty acids and persists after detoxication. Linoleic acid content in free fatty acids returns to the normal values following detoxication. An increase in oleic acid level accompanying a decrease in linoleic acid concentration is probably secondary to the stimulation with hydrogen excess formed during alcohol fermentation.

Adult↗
PubMed1989

[Multiple sclerosis and psoriasis].

Among 51 patients with clinically probable multiple sclerosis three had typical chronic psoriasis. The incidence of psoriasis in the studies group of multiple sclerosis patients was higher (one case per 17 patients) than in the general population (one per 33 subjects). In all three cases psoriasis developed before the beginning of remitting multiple sclerosis and showed no correlation with the exacerbations of the neurological disease or with the degree of neurological function loss. The presence of histocompatibility antigens (HLA), immunopathological and biochemical changes in both diseases is discussed.

Adult↗
PubMed1979

Antilymphocyte globulin and adrenal steroids in the treatment of multiple sclerosis: short report based on seven cases.

A therapeutic trial of antilymphocyte globulin (ALG) combined with dexamethasone was carried out in 7 patients with chronic, relapsing multiple sclerosis. ALG was given intravenously in daily doses of 0.25-0.5 g on the weekdays over 1 to 2 months. Total doses of ALG ranged from 12.5 to 17.7 g. Follow-up made after 1 year showed that 2 had no deterioration and 2 became worse in "tolerant" group, and 2 showed no deterioration and 1 revealed fatal progression in "non-tolerant" group. The treatment proved to be toxic in 3 patients. This pilot study suggests that ALG enhances anti-inflammatory activity of adrenal steroids in some patients, but does not seem to change natural course of the disease.

Adult↗
PubMed1978

Levamisole in multiple sclerosis; with special reference to immunological parameters. A pilot study.

Nineteen patients with multiple sclerosis (MS) have been given one course of levamisole therapy, and 16 patients two courses of levamisole treatment in daily dosages of 100--150 mg over two periods lasting from 1 month to 22 weeks each. Clinical effect was evaluated using Kurtzke's disability status scale. Immediate clinical evaluation showed that 15 patints remained unchanged, two improved and two became worse. Follow-up revealed after 4--14 months that another four patients deteriorated and none improved. Altogether 10 patients developed 13 relapses. During this brief therapy, no convincing conclusions may be drawn regarding an influence upon the course of the disease, although there is the suggestion that levamisole was not beneficial in MS patients. There was no statistically significant effect of levamisole on peripheral blood lymphocyte count, lymphocyte stimulation tests, leucocyte migration inhibition tests, short and long incubation E-rosette forming cells and serum IgA, IgG or IgM levels. A group of MS patients showed after 1 month of levamisole treatment either short-lasting restored or potentiated skin hypersensitivity to bacterial and fungal antigens (P less than 0.05).

Administration, Oral↗