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Biomedical subjects

W C Weese

Publications and source records attributed to W C Weese.

10 recordsLinked to original sources
PubMed1979

Fat embolism.

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Adult↗
PubMed1977

Smoke inhalation.

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Environmental Exposure↗
PubMed1976

Presence of a bradykinin-like substance in pulmonary washings.

Pulmonary washings were studied for the presence of bradykinin-like substances and the capacity for their formation and degradation. Bronchopulmonary lavage with saline was performed in anesthetized, exsanguinated Syrian golden hamsters with a cell yield of 99 per cent alveolar macrophages. In the presence of inhibitors of both kinin formation (hexadimethrine) and destruction (1,10-phenanthroline), immunoreactive kinin was found in bronchopulmonary lavage fluid (12.5 ng per 5 x 10(6) cells lavaged), washings of pooled macrophages (5.62 ng per 5 x 10(6) cells washed), and lysates of alveolar macrophages (3.97 ng per 5 x 10(6) cells lysed). Higher kinin concentrations were obtained by selective inhibition of kinin-destroying enzymes with phenanthroline. Inhibition of kinin formation with hexadimethrine alone rendered nearly all concentrations below the limit of detectability. These findings demonstrated that the capacity for kinin formation and degradation exists in pulmonary washings. The precise origin of this kinin and its forming and destroying enzymes (whether from the pulmonary alveolar macrophage, other sites in the bronchopulmonary tree, or plasma) is not yet known.

Animals↗
PubMed1976

Case report.

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Adenocarcinoma, Bronchiolo-Alveolar↗
PubMed1975

Interstitial lung disease resistant to corticosteroid therapy. Report of three cases treated with azathioprine or cyclophosphamide.

Three patients with severe progressive interstitial lung disease refractory to steroid therapy were treated with immunosuppressive drugs. Biopsy material of one showed mainly fibrosis, while that of the second showed interstitial pneumonitis as well; both patients received azathioprine. Cyclophosphamide was employed in the third patient with systemic vasculitis and massive hemoptysis. All patients had reduced lung volumes and abnormal gas exchange, which continued to worsen on high doses of steroids. In patients 1 and 2, there was long-term stabilization of lung function, while pulmonary physiologic abnormalities in the patient with vasculitis reverted to normal on five months of cyclophosphamide. Although the etiology of most forms of interstitial lung disease is unknown, several reports suggest at least a partial immunologic basis. Abatement in progression of disease in this small series would suggest that a trial of immunosuppressive drugs be considered in interstitial lung disease when steroid therapy fails.

Adult↗
PubMed1975

A study of 57 cases of actinomycosis over a 36-year period. A diagnostic 'failure' with good prognosis after treatment.

Actinomycosis continues to elude the clinician. In only four of 57 patients seen at the University of Iowa Hospitals (and in none of 12 since 1958) the disease was correctly diagnosed on admission. The disease is more common in men, but has no seasonal or occupational predilection. A normal inhabitant of the mouth, Actinomyces israelii acts as an opportunistic infection, usually in association with bacterial invasion. It tends to follow a break in normal mucosal barriers. Fistula and palpable mass are the physical hallmarks, with pain and fever the most frequent symptoms. Definitive identification requires anaerobic culture. Chances for cure are excellent with lengthy antibiotic administration.

Actinomycosis↗