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Biomedical subjects

W C Watson

Publications and source records attributed to W C Watson.

88 records · Page 5Linked to original sources
PubMed1967

Rgulation of intestinal alkaline phosphatase levels in the rat. Role of the adrenal cortex.

Bilateral adrenalectomy produces a reduction in the alkaline phosphatase concentration in rat intestine, which is not prevented by the administration of saline, but is prevented by the administration of cortisone. The administration of A.C.T.H. to normal rats leads to a rise in intestinal alkaline phosphatase levels associated with a small increase in the weight of the adrenals, while the administration of hydrocortisone produces large increases in the enzyme, even with doses which cause significant hypoplasia of the adrenal glands. The significance of these findings in relation to mechanisms of fat absorption and the treatment of steatorrhoea is discussed.

Adrenal Glands↗
PubMed1966

Fat digestion and absorption in the adrenalectomized rat.

Malabsorption of fat in the adrenalectomized rat has been confirmed. The criteria for adrenal hypofunction were more rigorous than in previous studies. The malabsorption is not due to impaired intestinal lipolysis or inadequate intestinal intracellular glyceride synthesis. Delayed gastric emptying is probably secondary to the malabsorption rather than a cause. It is postulated that impaired intestinal fatty acid activation may be the key defect and that in some way this inhibits fatty acid transport across the mucosal membrane.

Adrenalectomy↗