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Biomedical subjects

W C Shoemaker

Publications and source records attributed to W C Shoemaker.

At least 145 records · Page 8Linked to original sources

Resuscitation of the critically ill patient. Use of branched-chain decision trees to improve outcome.

The algorithm approach provides criteria based on decision rules for expeditious monitoring, diagnostic and therapeutic decisions; algorithms are particularly useful in crisis situations, in which time is of great importance, for example, in the resuscitation of emergency patients. Because of its objectivity and usefulness as a teaching tool, this algorithmic approach is of practical benefit in the training of residents and students in teaching hospitals, as well as in the community hospital where less experienced physicians manage hypotensive emergency patients more infrequently. In a few instances there has been some reluctance to use the algorithm, but most often it was found to be useful in organizing the work-up and establishing therapeutic priorities. A second branched-chain decision tree was designed for use after the initial resuscitation in hemodynamically unstable patients who only had CVP catheters but were suspected of having hypovolemia. In this algorithm, MAP, HR, urine output, Hct, and CVP are used as criteria. The underlying premise under these conditions was to evaluate increments of volume therapy without exceeding safe CVP pressures (less than 18 mm Hg) in order to obviate fluid overloading. A third algorithm for ICU patients with pulmonary artery catheters was developed from decision rules based on objective physiologic, heuristic, survival data as the criteria for post-trauma and postoperative patients who were critically ill despite apparent success with the initial resuscitation and CVP algorithms. The improved mortality in prospective studies supports the hypothesis that compensatory responses of the survivors are the major determinants of outcome.

Abdominal Injuries↗

Conjunctival and mixed-venous oximeters as early warning devices of cardiopulmonary compromise.

To evaluate potential clinical applications of conjunctival (PcjO2) and mixed venous (SvO2) oximeters in the care of surgical patients, we compared continuous measurements of PcjO2 and SvO2 to conventional invasive hemodynamic and oxygen transport variables during normoxia, hyperoxia, hypoxia, hemorrhagic shock, and resuscitation in dogs. During the normoxic control periods, PcjO2 averaged 76% of the arterial oxygen tension (PaO2). During hyperoxia and hypoxia, PcjO2 correlated well with PaO2 values (r = 0.88) but not with mixed venous oxygen tension (PvO2), whereas the SvO2 correlated well with PvO2 (r = 0.88) but not with PaO2 values. Controlled hemorrhage produced significant, progressive decreases in PcjO2, SvO2, cardiac output, and oxygen delivery (P less than 0.01), whereas PaO2 values remained constant throughout this period (FIO2 = 40%). There were no significant differences between the decreases in PcjO2 and SvO2 at 15, 30, and 45 ml/kg blood loss. Reinfusion of the shed blood resulted in a rapid, significant increase in PcjO2, SvO2, cardiac output, and oxygen delivery (P less than 0.01); the PaO2 remained constant. During hemorrhage and resuscitation, both PcjO2 and SvO2 tracked cardiac output; the weighted mean correlation coefficient, rw, was 0.90 for both PcjO2 versus cardiac output and SvO2 versus cardiac output. The correlation coefficient for PcjO2 versus SvO2 during hemorrhage and resuscitation was 0.72. One dog died unexpectedly during hemorrhage. In the 29 min period immediately prior to death, PcjO2 remained at 9 torr and SvO2 at 10%; the simultaneously measured PaO2 was 133 torr. Both oximeters had in vivo stabilization and 90% response times of less than 2 min. We conclude that both oximetry systems are potentially useful in high-risk surgical patients to provide better cardiorespiratory surveillance and to signal the need for more intensive assessment of hemodynamic stability. This approach may lead to reduced costs from unnecessary invasive procedures as well as reduced morbidity secondary to earlier warning of cardiorespiratory compromise.

Animals↗

Common bile duct anastomosis using fibrin glue.

Transection of the common bile duct (CBD) secondary to iatrogenic or civilian trauma is a devastating injury associated with a high incidence of complications, especially biliary fistula and stricture formation. We evaluated the efficacy of Fibrin Sealant--a biologic adhesive containing highly concentrated human fibrinogen--in primary end-to-end anastomosis of the transected CBD in ten adult mongrel dogs. Postoperative T-tube stents in the CBD anastomosis and abdominal drainage were not used. Only two absorbable sutures were used for each CBD anastomosis. The dogs were reexplored postoperatively at intervals varying from one week to nine months; cholangiography was performed at postoperative intervals varying from one to six months. Examination of CBD specimens harvested one month or more after surgery revealed complete healing and no signs of previous injury. Histologic examination disclosed well-healed ductal tissue, without a significant inflammatory response. One dog had an anastomotic leak, and two had moderate narrowing of the CBD anastomosis. Our experience in experimental CBD anastomosis indicates that Fibrin Sealant helps seal biliary anastomoses against leakage; controls bleeding from cut edges of bile duct segments; has good systemic and local compatibility; may promote bile duct wound healing; and significantly reduces the number of sutures needed for primary repair, thereby decreasing the potential for anastomotic ischemia, mucosal damage, and biliary stricture formation.

Animals↗

Common physiologic patterns in general surgical patients: hemodynamic and oxygen transport changes during and after operation in patients with and without associated medical problems.

An examination of perioperative cardiorespiratory parameters in surviving and nonsurviving patients has identified several physiologic responses to the stress of surgical trauma, namely enhancement of circulatory performance and oxygen transport. When specific subsets of surgical illness are examined, it was found that these responses often began from different plateaus of baseline function. Because these responses are greater in survivors than nonsurvivors and this relationship is fairly consistent among a variety of surgical illnesses, it would seem that duplicating or augmenting these responses would be a rational goal for therapeutic intervention that would lead to improved patient outcome.

Age Factors↗

Therapy of critically ill postoperative patients based on outcome prediction and prospective clinical trials.

An objective physiologic approach to therapy of high-risk postoperative patients was developed using survival as the criterion to determine the relative importance of variables and optimal goals for these variables. A protocol, based on a branch chain decision tree, also was developed from outcome data. When tested prospectively against the standard of care, this protocol markedly reduced mortality and morbidity.

Cardiovascular System↗

Controversies in the pathophysiology and fluid management of postoperative adult respiratory distress syndrome.

Physiologic changes that lead to the development of ARDS begin with the precipitating shock syndrome. Hypovolemia, pulmonary vasoconstriction, reduced myocardial performance, and diminished O2 transport typically precede the development of clinical ARDS after hemorrhage, trauma, postoperative conditions, and sepsis. Since shock lung is a complication of shock, it is not surprising that the antecedent clinical and physiologic events that characterize the shock state may be determinants of both the genesis and the outcome of ARDS. Postoperative ARDS follows unrecognized or inadequately treated hypovolemia and hypoxia during an antecedent period of preoperative or intraoperative shock. Hypovolemia and hypoxia increase cardiac and ventilatory drive and stimulate neurohumoral mechanisms to increase pulmonary vasoconstriction. The last-named, when extensive and uneven, produces maldistribution of flow and reduces DO2 and VO2. Subsequently, mediator-induced pulmonary vasoconstriction increases the problem. When sufficiently extensive, these antecedent physiologic alterations culminate in ARDS. With impaired flow and O2 transport, pathogenic mechanisms of ARDS and acute renal failure may be set in motion; further, the naturally occurring immune mechanisms may be impaired and may lead to associated infection. There are at least six redistributions that are major pathophysiologic influences in ARDS. They are uneven ventilation throughout the lung; redistribution of regional pulmonary blood flow between zones due to gravity; nonuniform pulmonary blood flow between individual metarteriolar-capillary networks because of local vasoconstriction; uneven systemic blood flow between organs; irregular systemic blood flow at the microcirculatory level, producing inadequate nutritional flow to the tissues; and redistribution of body water, leading particularly to fluid accumulation in the extracellular compartment, with expanded interstitial space and contracted plasma volume (hypovolemia). Pathogenic roles have been implicated for capillary leak, surfactant synthesis, erythrocyte and platelet aggregation, leukocyte margination in the pulmonary circulation, complement and kinin cascades, neurohumoral responses, histamine, serotonin, vasoactive peptides, and the metabolic products of arachidonic acid breakdown in pulmonary vessels. However, these potential pathogenic influences have yet to be described in terms of their temporal relationships to the natural physiologic history of ARDS; nor have their roles been evaluated in terms of mechanistic interrelationships.(ABSTRACT TRUNCATED AT 400 WORDS)

Blood Transfusion, Autologous↗

Hemodynamic and oxygen transport patterns in surviving and nonsurviving postoperative patients.

Invasive hemodynamic monitoring was performed on 220 critically ill surgical patients judged by clinical evaluation to have a high likelihood of surgical complications or death. Patients with markedly abnormal preoperative hemodynamic values were excluded from analysis. Data were separated into preoperative, intraoperative and postoperative time intervals and the mean value of each variable for each patient at each time period was computed. In comparison to survivors, the nonsurvivors generally had: (a) reduced myocardial performance as judged by lower cardiac index and left ventricular stroke work in the presence of high right and left ventricular filling pressures, (b) reduced pulmonary function (increased alveolar-arterial oxygen content difference and pulmonary shunt fraction), (c) pulmonary vasoconstriction (increased pulmonary artery pressure and pulmonary vascular resistance), and (d) decreased oxygen delivery despite maintenance of normal arterial blood gases and comparable hemoglobin values. Both survivors and nonsurvivors had vital signs usually within the normal range (until the terminal state of nonsurvivors).

Adult↗

Probability of survival as a prognostic and severity of illness score in critically ill surgical patients.

A new quantitative method for measuring the prognosis and severity of illness in terms of probability of survival was developed from 224 studies in an index population of 220 critically ill surgical patients. Patients were selected preoperatively to eliminate pre-existing cardiac disease, cirrhosis, nutritional debility, shock or sepsis, in order to evaluate the physiologic relationships of surgical trauma to outcome free of confounding associated medical disorders. The empirically derived numeric severity index was calculated from the probability of survival for each of 28 hemodynamic and oxygen transport variables at each time period after surgery. The score correctly indicated patient outcome in 96% of the index population and 94% of an independent, prospective population. The survivors' score consistently predicted survival within 21.6 +/- 4.4 (SEM) h after the end of surgery. The severity score of those who died consistently predicted nonsurvival within 37 +/- 11 (SEM) h after the end of surgery. We conclude that the score provides a useful, objective, physiologic measure of the severity of illness and prognosis.

Biological Transport↗

Pathophysiology of adult respiratory distress syndrome after sepsis and surgical operations.

To describe the natural history of adult respiratory distress syndrome (ARDS) from the circulatory viewpoint, we measured hemodynamic and oxygen transport variables in a series of 126 postoperative and 65 septic ARDS patients. All patients had hypoxemia unresponsive to conservative measures and required mechanical ventilation. Data from this series were compared with data from normal healthy volunteers and from postoperative patients who did not develop ARDS. In addition, the temporal sequence of cardiorespiratory changes in the ARDS patients was observed for a 48-h period before and after ARDS was diagnosed. Before the development of ARDS, both postoperative and septic patients exhibited hypovolemia, pulmonary vasoconstriction, suboptimal myocardial performance, and reduced oxygen delivery and consumption relative to the increased needs of the hypercatabolic state. Because these antecedent changes were greater in ARDS patients who died, their early correction (in addition to standard ventilatory support) may prevent the development of ARDS and decrease its mortality.

Adult↗

Continuous polarographic monitoring of intra-arterial oxygen in the perioperative period.

Intra-arterial PO2 (PiO2) was polarographically monitored in ten critically ill patients during induction of anesthesia, the intraoperative period, extubation, and the immediate postoperative period; 147 PiO2 values were then paired with simultaneous measurements of PaO2. Mean PiO2 closely followed mean PaO2 over a wide range of values (r = .97), and the continuous, online real-time PiO2 readings provided a useful early warning system for hypoxemia during crisis periods. Technical problems included catheter clotting from improper flushing, changes in PiO2 due to changes in body temperature, the need for in vitro and in vivo calibration, and sensor drift. However, these problems were resolved by appropriate catheter management and sensor calibration.

Blood Gas Analysis↗

Transcutaneous oxygen recovery and toe pulse reappearance time in the assessment of peripheral vascular disease.

The accuracy of measurements of transcutaneous oxygen tension (Ptco2) in the diagnosis of peripheral vascular disease (PVD) may be significantly increased by stressing limb circulation with the use of temporary ischemia. The purpose of this study was to compare the transcutaneous oxygen recovery half-time (TORT) and the toe pulse reappearance time (PRT/2) in a series of patients with symptomatic PVD before and after vascular reconstruction. The TORT was defined as the time required to recover half of the decrease in the limb/chest Ptco2 ratio caused by temporary limb ischemia, and is conceptually comparable to the toe PRT/2, the time required to recover half of the control toe pulse amplitude. Measurement of TORT was found to be more feasible (100% vs 58%) and to have a greater diagnostic yield (100% vs 92%) than that of the toe PRT/2. When measured on the dorsum of the foot, TORT values were found to correlate well with the severity of symptoms of PVD; toe PRT/2 values did not correlate with severity of symptoms. Patients who underwent successful vascular reconstruction had significant improvement in their calf and foot TORT values after surgery (p less than .005 and .0005, respectively); postoperative values were similar to those obtained in normal subjects. Toe PRT/2 values usually improved postoperatively, but in many patients postoperative values overlapped with values that were considered abnormal. There was no overlap of TORT values in normal subjects with those in patients with symptomatic PVD. The measurement of TORT may be clinically useful for screening patients with suspected PVD and for assessing quantitatively the results of conservative and surgical therapy.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

Tracheal repair with fibrin glue.

This animal study evaluated Fibrin Sealant, a multicomponent biologic adhesive, in tracheal operations. We conclude that the use of Fibrin Sealant in tracheal reconstruction results in a stable, leakless trachea, has good systemic and local compatibility, promotes tracheal wound healing, and reduces significantly the number of sutures required for end-to-end anastomosis.

Animals↗

Cardiorespiratory patterns in severe delirium tremens.

To define the hemodynamic and oxygen metabolism patterns associated with severe delirium tremens, we examined cardiorespiratory variables in five patients over the 24 hours before (control), at the time of (delirium tremens), and during the 24 hours after resolution of (postresolution) delirium tremens. In comparing the delirium tremens period with the control period, significant increases were found in mean +/- SD cardiac index (4.9 +/- 1.7 L/min X sq m vs 3.6 +/- 0.7 L/min X sq m), left cardiac work index (6.4 +/- 2.4 kg X m/sq m vs 5.0 +/- 1.7 kg X m/sq m), oxygen delivery (681 +/- 204 mL/min X sq m vs 546 +/- 176 mL/min X sq m), and oxygen consumption (204 +/- 38 mL/min X sq m vs 165 +/- 16 mL/min X sq m). Values for the control and postresolution periods were not significantly different. These results demonstrate that a hyperdynamic cardiorespiratory state is present during delirium tremens; this increased cardiac output may be a compensatory hemodynamic response to increased oxidative metabolism that requires additional therapeutic support.

Adult↗

Superiority of transcutaneous oximetry in noninvasive vascular diagnosis in patients with diabetes.

Transcutaneous oxygen tension Ptco2 is directly related to skin oxygen delivery. Regional transcutaneous oximetry ( RTO ) compares peripheral and truncal (Ptco2), yielding a regional perfusion index indicative of local limb perfusion. The relative diagnostic values of RTO , Doppler ankle-brachial pressure ratio (ABR), pulse volume recording (PVR), and toe pulse reappearance time (PRT/2) were studied in 64 limbs of patients with diabetes. These limbs were clinically classifiable into claudication, rest pain, and gangrene groups. Regional transcutaneous oximetry had a higher diagnostic accuracy than ABR (X2 = 27.47, P less than .001), PVR (X2 = 7.54, P less than .01), and PRT/2 (X2 = 10.99, P less than .001). Regional transcutaneous oximetry was universally applicable and the degree of hypoxia observed correlated with clinical symptoms. Significant hypoxia predicted large-vessel angiographic lesions, many of which were reconstructible . Regional transcutaneous oximetry should be the initial noninvasive test in diabetic peripheral vascular disease.

Aged↗

Cardiorespiratory effects of pneumatic trousers in critically ill patients.

Although pneumatic antishock trousers (PT) are widely used in prehospital and emergency care, little is known about their cardiorespiratory effects in critically ill patients. To examine this issue, we measured hemodynamic and oxygen metabolism variables in ten critically ill patients. All patients were studied with PTs uninflated, after five minutes of PT inflation to 40 mm Hg, and five minutes after PT deflation. Significant increase in mean arterial pressure, systemic vascular resistance, and pulmonary artery pressures were present after PT inflation. No significant changes in cardiac index, stroke index, arterial or mixed venous blood gas values, or oxygen delivery were found. There was a downward trend in VO2 that was on the border of statistical significance. Regression analysis of cardiorespiratory variables on blood volume demonstrated no physiologic effects of external counterpressure in hypovolemic, hypervolemic, or normovolemic patients. We concluded that PT inflation increases BP through its effects on peripheral resistance. No significant autotransfusion effect was present, and there was a suggestive impairment in oxygen metabolism.

Adult↗

The use of surface oximetry to assess bowel viability.

Tissue depends on perfusion, but tissue oxygenation measurements have been impractical. To develop a method for the clinical evaluation of bowel viability, we studied PO2 on the bowel surface (PSO2). The PSO2 was assessed on the stomach and intestine of 11 dogs. Normal small-bowel PSO2 was 44 +/- 11 mm Hg (mean +/- SD). When bowel vasculature was interrupted PSO2 rapidly decreased. Reductions in PSO2 were related to the degree of ischemia produced. Anastomoses were performed on partially devascularized bowel to determine anastomotic viability at various levels of PSO2. The PSO2 measured just prior to anastomosis predicted viability of the anastomoses at 48 hours. Anastomoses below 30% of predevascularization PSO2 necrosed. Between 30% and 50%, one third of anastomoses leaked. At PSO2 values above 50% of initial normal value all anastomoses healed. Surface oximetry allows accurate intraoperative assessment of bowel perfusion.

Animals↗