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Biomedical subjects

W C Roberts

Publications and source records attributed to W C Roberts.

At least 685 records · Page 38Linked to original sources

Chylomicrons and the formation of foam cells in type I hyperlipoproteinemia. A morphologic study.

Light and electron microscopic study of aspirated bone marrow of a patient with type I hyperlipoproteinemia disclosed large, birefringent foam cells which develop from phagocytosis of chylomicrons by histiocytes. Chylomicrons are taken up, singly and in aggregates, by infoldings of the plasma membranes of histiocytes; these infoldings become phagocytic vacuoles within the cytoplasm. As chylomicrons are metabolized, the foam cells decrease in size, lose birefringence and develop autofluorescent, electron-dense deposits of ceroid.

Adult↗