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Biomedical subjects

W C Morgan

Publications and source records attributed to W C Morgan.

10 recordsLinked to original sources
PubMed1998

Diagnostic evaluation of dyspnea.

Dyspnea is a common symptom and, in most cases, can be effectively managed in the office by the family physician. The differential diagnosis is composed of four general categories: cardiac, pulmonary, mixed cardiac or pulmonary, and noncardiac or nonpulmonary. Most cases of dyspnea are due to cardiac or pulmonary disease, which is readily identified with a careful history and physical examination. Chest radiographs, electrocardiograph and screening spirometry are easily performed diagnostic tests that can provide valuable information. In selected cases where the test results are inconclusive or require clarification, complete pulmonary function testing, arterial blood gas measurement, echocardiography and standard exercise treadmill testing or complete cardiopulmonary exercise testing may be useful. A consultation with a pulmonologist or cardiologist may be helpful to guide the selection and interpretation of second-line testing.

Blood Gas Analysis↗
PubMed1992

Histochemical probing of potato periderm with neutral red: a sensitive cytofluorochrome for the hydrophobic domain of suberin.

A technique is described which uses the lipid fluorochrome neutral red as a cytochemical probe to detect the hydrophobic domain of the ligno-suberin matrix in native and wound periderm of potato tuber. Toluidine blue O is used as a counterstain to quench autofluorescence. The neutral red technique appears to be specific for the hydrophobic/lipid domain of suberin and is significantly more sensitive than Sudan III and IV. The fluorochrome was extensively used on paraffin-embedded tissue with excellent results but also worked on freehand sections of fresh periderm tissue. In tuber tissue undergoing wound-healing, the pattern of suberin fluorescence obtained with the neutral red probe was identical in specificity to the color pattern obtained with Sudan III/IV, but somewhat different than that observed when berberine was used. Results obtained with the neutral red probe and berberine probe visually demonstrated that during ligno-suberin biosynthesis, the depositions of hydrophobic/lipid and phenolic/lignin-like components in potato tuber periderm were separate processes. The deposition of these components does not necessarily require their simultaneous presence because the fluorescence from these probes showed that the components were not consistently present together on the cell walls.

Berberine↗
PubMed1988

Ultrasound for the primary care physician. Applications in family-centered obstetrics.

Ultrasound imaging is a noninvasive diagnostic tool that enhances the patient's and physician's understanding of prenatal care. According to a multisite study, use of ultrasound by primary care physicians appears to improve prenatal patient education and support early formation of the family unit. Other potential benefits include early detection of fetal abnormalities, savings in time and cost, and enhanced continuity of care. However, consultation with and referral to specialists, when appropriate, remain essential ingredients for state-of-the-art healthcare. Further studies defining the role and boundaries of ultrasound in primary care are needed.

Adult↗
PubMed1988

Recombinant retroviruses that transduce middle T antigen cDNAs derived from polyomavirus mutants: separation of focus formation and soft-agar growth in transformation assays and correlations with kinase activities in vitro.

To study correlations between cellular transformation and the biochemical properties of polyomavirus middle T antigen, middle T cDNAs have been derived from the polyomavirus mutants dl1015, dl23, and NG59b and have been introduced into rodent fibroblast cell lines by using a retrovirus vector. It was found that all three mutants are completely defective in inducing growth in soft agar but possess a range of activities in assays of focus formation on cell monolayers. Furthermore, when assays of middle T antigen-associated kinase activities were performed in vitro, a correlation between the level of associated phosphatidylinositol kinase activity and the ability of mutant middle T antigens to induce focus formation was observed. However, the association of this activity with middle T antigen does not appear to be sufficient to bring about full transformation, since the middle T antigen derived from dl1015 is completely defective for soft-agar growth but is associated with a level of phosphatidylinositol kinase activity which is comparable to that of the wild type. Therefore, some other unidentified middle T antigen function may also be required for full transformation.

1-Phosphatidylinositol 4-Kinase↗
PubMed1985

Effectiveness of a dentifrice containing formalin and sodium monofluorophosphate on dental hypersensitivity.

A double-blind investigation comparing a control dentifrice with one containing active ingredients was conducted to determine their effect on dentinal hypersensitivity in 67 human subjects. Baseline data was obtained by patient questionnaire, dental examination and by soliciting subjective responses to controlled mechanical and thermal stimuli. A calcium carbonate-based toothpaste constituted the base for both the control and active dentifrice. The active dentifrice contained 0.8% sodium monofluorophosphate and 1.3% formalin while the control lacked these ingredients. Dentifrices were supplied to patients on a random basis, and patients were instructed to brush twice each day for 28 days. Mechanical and thermal response as accomplished at baseline were obtained at 14 and 28 days after baseline on 60 subjects. A statistically significant reduction was not obtained in response to mechanical stimulus. The active dentifrice demonstrated a statistically significant reduction (P less than 0.05) to thermal stimulus at both 14 and 28 days.

Adult↗
PubMed1977

Tympanosclerosis.

Tympanosclerosis is a pathological condition which results in deposits of dense hyaline tissue or even bone in the lamina propria of the middle ear mucous membrane. It is induced by chronic inflammation in the middle ear, and is likely a Type III immune complex disease. Clinical tympanosclerosis results in decreased sound conduction by fixing ossicles or the tympanic membrane, or by obstruction to ventilation of the middle ear or mastoid. Management is dictated by the location and extent of the tympanosclerotic involvement. Ossicular problems are met by removal of the tympanosclerosis and reconstruction of the chain. The exception to this is in involvement of the stapes and oval window where stapedectomy is usually necessary. Tympanosclerosis is not expected to recur, but in the oval window fibrous scarring usually refixes a mobilized stapes. A greater incidence in recent years is due to an increased awareness and interest.

Humans↗
PubMed1977

Adult mortality rates in Leghorn X Red reciprocal crosses at three North Central stations.

Adult mortality rates among progeny of Leghorn X Red reciprocal crosses were observed concurrently at three North Central Region experiment stations. Female mortality rates were significantly (P less than or equal to .05) higher at all locations among progeny of the Leghorn male parent. Male mortality rates (observed at two locations) between crosses were not different and thus suggested a sex chromosome involvement with mortality rates in these crosses.

Animals↗
PubMed1975

Pediatric mandibular fractures.

This article is a study of the experience with mandibular fractures at a large pediatric hospital. A total of ninety-four mandibular fractures in sixty-three patients is reviewed. The cause, location, male-female ratio, occurrence of multiple fractures, and associated problems are studied.

Adolescent↗
PubMed1975

Dental anesthetic management of epidermolysis bullosa: a new approach.

Epidermolysis bullosa is a rare blister-producing skin disorder that has been of some concern to dentists in the past. Dental treatment has been attempted on an outpatient basis with local anesthesia. In some of these patients, local anesthesia has caused large intraoral bullae. Other methods of treatment have been sought, including the use of general anesthesia and intramuscular sedation. This is a report of a case in which intravenous ketamine hydrochloride was used with good results. We believe this method has much to offer in the treatment of these patients.

Anesthesia, Dental↗