Twenty years of equine research. A review of the work of The Animal Health Trust's Equine Research Station from January 1st, 1947-December 31st, 1966.
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Biomedical subjects
Publications and source records attributed to W C Miller.
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The infectiousness of the index case and the susceptibility of the exposed host mediate the sexual transmission of human immunodeficiency virus (HIV). Infectiousness of the index case is determined by the inoculum of HIV and viral factors that favor transmission. Persons with primary infection, late stage disease, or low CD4 counts appear to transmit HIV with greater efficiency, presumably through increased viral burden in genital secretions. Susceptibility to HIV infection is determined by hereditary resistance factors, acquired immunity, site of exposure to the virus, and integrity of local barriers (e.g., vaginal epithelium). Hereditary resistance factors, such as cell surface receptors required for transmission of some viral variants, have been identified in studies of exposed, but uninfected persons. Acquired immunity, including protective cytotoxic T lymphocyte or antibody responses, may be important in persons repeatedly exposed to HIV who do not become infected. Sexual practices also affect susceptibility, with receptive anal intercourse having the highest risk, followed by vaginal intercourse and fellatio. Similarly, women are more susceptible to infection than men, through vaginal intercourse. In general, any factor affecting excretion of HIV or the number of receptive cells can be expected to affect the efficiency of transmission.
PURPOSE: In this study we assessed whether balance confidence scores changed over a 2-year follow up period, and identified predictors of balance confidence and predictors of change in balance confidence among lower limb amputees. METHOD: A prospective follow-up survey of 245 community living adults with unilateral below and above knee lower limb amputation who used their prosthetic limb daily was conducted. Balance confidence, assessed using the 16-item Activity-specific Balance Confidence (ABC) Scale, socio-demographic, health and amputation related variables were collected at baseline and 2 years later. RESULTS: ABC scores were similar at baseline (mean = 67.6; SD = 25.7) and follow up (mean = 68.0; SD = 25.8). Lower balance confidence scores at follow up were predicted by older age, being female, use of a mobility device, poor perceived health, increased symptoms of depression, having to concentrate while walking, and fear of falling (all p < 0.05). Predictors of change in balance confidence included gender and perceived health (all p < 0.05). CONCLUSION: Balance confidence appears to be a persistent problem in the amputee population. Health professionals are encouraged to consider balance confidence as a potentially important variable that may influence function in this clinically unique group of individuals. The identified predictor variables may be useful to clinicians in targeting individuals who require attention to improve balance confidence.
In an attempt to predict survival of open-heart surgery, particularly among high risk subjects who undergo extra-corporeal circulation [ECG] using pump oxygenation perfusion, a preoperative battery including intellectual, personality and neuropsychological instruments and also ratings of cardiac impairment, was administered to 15 control [cardiac surgery without ECG] and 72 experimental [ECG] subjects. Subjects were divided into survivor [S] and fatality [F] groups, and preoperative test data were analyzed using multivariate stepwise discrimination techniques. In a variety of analyses, at least 86% and as high as 100% of subjects were correctly classified as survivors or fatalities on the basis of variables sampled, indicating the outcome of cardiac surgery may be predicted preoperatively with a high degree of accuracy.
An evaluation instrument called the diabetes self-management record has been developed to better document the positive behavioral changes associated with diabetes education programming. This record is a simple behavior monitoring system that awards points for positive behaviors associated with exercise, glucose monitoring, and nutrition management. A group of 39 adults with diabetes monitored their behaviors with the record prior to, immediately after, and 4 to 6 weeks following a diabetes education programming course. Overall diabetes management scores were higher (mean +/- SEM = 56.2 +/- 3.5 vs 66.3 +/- 2.9) following the educational intervention, as well as specific behavioral scores for exercise, glucose monitoring, fat consumption, refined sugar/carbohydrate consumption, and eating behavior. These behaviors were maintained for at least 4 to 6 weeks postprogramming. The diabetes self-management record can be used as an adjunct to diabetes education programming, as an evaluator of the educational intervention, and/or as a behavior monitoring tool for diabetes self-management.