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Biomedical subjects

W C Hop

Publications and source records attributed to W C Hop.

At least 307 records · Page 17Linked to original sources
PubMed1983

Cancer of the urinary bladder category T2, T3, (NxMo) treated by interstitial radium implant: second report.

Three-hundred-twenty-eight patients with bladder cancer category T2NxMo and 63 patients with category T3NxMo have been treated by 3 times 3.5 Gy external irradiation followed by a radium implant. Overall 5- and 10-year survival in the T2 category are 56%. In the T3 category they are 39% and 13%, respectively. The intercurrent death (i.e. without evidence of bladder malignancy) corrected actuarial survival percentage in the T2 category is 75% at 5 years and 69% at 10 years. The corresponding percentages in the T3 category are 62% and 59%. Prognosis is worsened by the following factors: more than 1 diagnostic transurethral resection, a pathological intravenous pyelography, non-papillary structure and poor degree of differentiation of the growth. Prognosis in category T3, as compared with category T2, is worse because of the prevalence of bad prognosticators in this T3 category. Therapeutic adaptation to these findings might improve prognosis in the future.

Aged↗
PubMed1983

Irradiation of true pelvis for bladder and prostatic carcinoma in supine, prone or Trendelenburg position.

Small bowel transit was performed in 50 patients with bladder or prostatic carcinoma. The patients were all examined in supine and prone positions; some were also studied in 25 degrees Trendelenburg position and 25 degrees inclined procubitus to investigate the effect of the various positions on the displacement of the small bowel loops out of the true pelvis. The prone position proved to be superior to the supine position in 78% of patients. A mean displacement of 0.9 cm was obtained. Greatest shifts generally were found in the Trendelenburg position and inclined procubitus, with a mean displacement of 1.9 and 2.0 cm, respectively. The patients' height, weight, maximal abdominal circumference and Quetelet's index were analyzed with regard to the shifts of bowel loops under the various conditions. Only weight and Quetelet's index were correlated with the shifts in the Trendelenburg and inclined procubitus positions. The shifts were generally larger in case of heavier patients. We conclude that pelvic irradiation should preferably be done in the Trendelenburg or inclined procubitus position, especially in case of obesity.

Body Height↗
PubMed1983

Carcinoma of the urinary bladder category T3NxMo treated by the combination of radium implant and external irradiation: second report.

Forty-one patients with bladder cancer, T3NxMo, with a diameter not exceeding 5 cm, were treated by 3 times 350 rad external irradiation, radium implant at reduced dose, and an additional 3000 rad external irradiation ("Radium 55%"). Survival is excellent where there is a high or medium degree of differentiation without vascular invasion in the biopsy specimen; prognosis is poor if a low degree of differentiation is combined with vascular invasion. The future therapeutic approach will be adapted to this finding.

Brachytherapy↗
PubMed1983

Carcinoma of the tonsillar region. A review of 78 cases.

The results of treatment of 78 patients with carcinoma of the tonsillar region treated in the Rotterdam Radiotherapy Institute in the period of 1970 to 1980 are discussed. Patients were classified according to UICC criteria [16]. An increasing local recurrence rate was noted with increasing T-category. The incidence of distant metastasis was higher in patients with nodal metastasis. Overall 5-year survival was 35%, intercurrent death corrected survival 53%. A strong correlation was present between stage and survival. Patients of 60 years or younger had a significant better prognosis than older patients; this was seen in every stage group. Infiltration at the base of the tongue decreased prognosis. Patients in whom induction therapy was given with intravenous methotrexate prior to irradiation did not show a better survival than those without such chemotherapy.

Adult↗
PubMed1982

Carcinoma of the urinary bladder T3NxMo treated by preoperative irradiation followed by simple cystectomy.

One hundred eighty-three patients with bladder cancer category T3NxMo (the diameter of the primary exceeding 5 cm), were treated by preoperative 40 Gy and simple cystectomy. Using only pretreatment information, the group with the best prognosis was characterized by a T3A-growth with a normal intravenous pyelography, with about a 75% cure rate. Before cystectomy, after irradiation the combination of a clinically assessed radiation-downstaged growth (T40GY less than 3) with normal urography, predicted the best chance of cure at about 80%. After cystectomy was performed, the best prognostic group could be most correctly identified: those patients with both microscopic downstaging of the primary ("P" less than 3) and no vascular invasion in the cystectomy specimen (CV-) combined with normal urography had an 81% chance of cure. This most favorable group constitutes 45% of all patients.

Aged↗
PubMed1982

Radiation therapy of testicular non-seminomas.

The prognosis of 121 patients with a non-seminoma testicular tumor MTI or MTU was assessed. The clinical lymph node involvement and the T-category of the primary had a significant bearing on prognosis, which is completely determined by pulmonary relapse. The low-risk group (9% pulmonary relapse, all curable) is characterized by a primary category T1 or T2 with negative lymphangiography. The percentage of favorable patients is significantly higher if there is malignant teratoma intermediate (MTI) rather than malignant teratoma undifferentiated (MTU) histology. Systematic use of tumor markers (beta 1 -HCG and alpha fetoprotein), and perhaps an assessment of vascular invasion in the primary, might be useful to identify those patients in the unfavorable group who might benefit from elective chemotherapy.

Chorionic Gonadotropin↗
PubMed1982

Carcinoma of the nasopharynx: a review of 86 cases.

The data of 86 patients, 63 males and 23 females, with nasopharynx carcinoma treated in the Rotterdam Radio-Therapeutic Institute in the period 1966-80 are discussed. Classification was made according to UICC (1978). We found an increasing local recurrence rate with increasing T category and an increasing regional recurrence rate with increasing N category. The incidence of regional metastasis was significantly smaller when elective neck irradiation was given. Distant metastasis was only seen in the more advanced stages. The five-year overall survival was 30%. A clear correlation between stage and prognosis was evident. Patients younger than 45 years of age at presentation fared markedly better than older patients. Increased survival for females as compared to males could be explained by differences in age and stage between the sexes. Females were younger and had a more favourable stage. To reduce the incidence of transverse myelitis, the dose to the spinal cord must be kept below 5000 cGy (rad) in five weeks.

Adolescent↗
PubMed1982

Reflux--a retrospective study of 100 ureteric reimplantations by the Politano-Leadbetter method and 100 by the Cohen technique.

The results of 100 consecutive ureteric reimplantations using the Politano-Leadbetter technique were compared with those of 100 cases operated on by the Cohen technique. This retrospective study was concerned only with the effect of the operation on the ureterovesical junction. Cure of reflux was achieved in 88 Politano-Leadbetter reimplantations and in 97 Cohen reimplantations. Both groups and the results are analysed.

Adolescent↗
PubMed1982

The influence of intramedullary nailing on the development of metastases in the treatment of an impending pathologic fracture: an experimental study.

An experimental model was developed to study the effects of a pathologic fracture and intramedullary nailing on metastatic spread. The end point used was the production of lung metastases in rats inoculated intracortically with a rat rhabdomyosarcoma. We found that a pathologic fracture markedly increases the incidence of lung metastases and that intramedullary nailing, by decreasing the incidence of fractures, decreases this incidence. The surgical procedure itself does not increase the incidence significantly. It is concluded that in metastatic disease prophylactic nailing of an impending pathologic fracture is the treatment of choice.

Animals↗
PubMed1981

Delayed alloimmunisation by random single donor platelet transfusions. A randomised study to compare single donor and multiple donor platelet transfusions in cancer patients with severe thrombocytopenia.

The effects of single-donor (SD) and multiple-donor (MD) platelet transfusions in 34 cancer patients with severe thrombocytopenia and haemorrhages were compared in a randomised study. Platelet recovery values in both groups were similar after the first transfusion. After the second transfusion platelet recovery values were significantly better in those receiving SD transfusions. Platelet recovery values gradually declined with subsequent MD transfusions. These results suggest early alloimmunisation in the MD transfused patients only. MD transfusions were estimated to be no longer effective after about nine transfusions. Platelet recovery values were better indicators of early sensitisation than was the lymphocytotoxicity test. Restriction of the number of donors per transfusion may postpone the development of refractoriness to random-donor platelet transfusions in thrombocytopenic patients.

Blood Donors↗
PubMed1980

Progestin therapy in advanced breast cancer: megestrol acetate--an evaluation of 160 treated cases.

Progestin megestrol acetate treatment of 160 postmenopausal women with progressive metastatic breast cancer is evaluated. Objective remission was found in 48 patients (30%) and stabilization of disease occurred in 58 (36%) cases. In each of these response categories, the median time interval before subsequent progression took place was nine months. Patients with a postmenopausal age of more than five years showed a significantly higher remission rate than did younger patients. In addition, great differences in remission rates were apparent between groups of patients classified according to dominant sites and separate sites of lesions. The length of disease-free interval did not prove to be of great importance in predicting the remission. No great difference in remission rates were found between patients treated with megestrol acetate as the first hormonal treatment and those previously treated with hormones. Side effects were negligible; a moderate weight increase without demonstrated fluid retention was found during therapy in 10% of the cases. Toxicity was not encountered. Megestrol acetate therapy may be the first choice of treatment in late postmenopausal patients with soft tissue and lung metastases.

Age Factors↗