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Biomedical subjects

W C Edwards

Publications and source records attributed to W C Edwards.

At least 55 records · Page 3Linked to original sources
PubMed1986

Pilot studies in cattle and mice to determine the presence of 4-methylimidazole in milk after oral ingestion.

4-methylimidazole (4-MI) was given orally to a cow in increased dosages to determine if it could be detected in her milk and be present at a concentration high enough to affect her nursing calf. 4-MI was found in the milk, but the calf remained clinically normal throughout the experiment. The cow died after the fourth dose of 20 g 4-MI. Four groups of 10 mice each were given oral doses of water, normal milk, cow's milk after low doses of 4-MI, or cow's milk after high doses of 4-MI. All mice remained healthy after a 2-week feeding trial. Six 3-day-old calves were given 4-MI directly in their bottles of milk up to 2 times the highest level found in toxic feed with only mild depression noted in one calf. Two pregnant cows were given 4-MI pre-partum to determine if it would get into the colostrum at higher levels. Both cows received 4-MI 3 days before they calved and for 2 weeks afterward. Cow A exhibited trembling, excessive salivation and incoordination after the initial dose. Cow B and the newborn calves were never affected throughout the experiment. Each time the dose of 4-MI reached 1.5 g or more, Cow A would exhibit the previously described signs. 4-MI was detected in the colostrum but not in higher concentrations than in the other milk samples.

Animal Feed↗
PubMed1982

Chondrodystrophic myotonia (Schwartz-Jampel syndrome): report of a new case and follow-up of patients initially reported in 1969.

We report on a 9-year-old boy with chondrodystrophic myotonia (Schwartz-Jampel syndrome) and the progress of a brother and sister with this syndrome first described in 1969. This is an autosomal recessive trait characterized by mask-like face, narrow palpebral fissures (due to blepharophimosis, blepharospasm, and abnormal orbital configuration), microstomia, micrognathia, myotonia, muscular hypertrophy, osteochondrodysplasia, and growth retardation. Expressivity varies and in some sibships females are less severely affected than their brothers. The sexual development of the sibs with chondrodystrophic myotonia, who are now in the mid to late second decade, has been normal. Linear growth rate accelerated during puberty but the adult height of the male is less than normal. Administration of human growth hormone had no consistent effect on the growth pattern of this boy.

Abnormalities, Multiple↗
PubMed1981

Radial nerve palsy at the elbow following venipuncture-case report.

A 29-year-old man sustained a radial nerve lesion when a blood bank technician attempted to cannulate the cephalic vein. Severe pain in the hand and fingers led to removal of the 16-gauge needle. A complete motor and sensory deficit occurred below the elbow. Electrical testing confirmed the neurologic lesion. Complete recovery took 3 months.

Adult↗
PubMed1980

Heavy metal concentrations in the kidneys of white-tailed deer in Oklahoma.

Concentrations of renal lead, arsenic, mercury and cadmium from 64 free-ranging adult white-tailed deer (Odocoileus virginianus) were determined. The mean concentrations in ppm wet weight and standard deviations for the metals were: lead, 0.574 +/- 0.646; arsenic, 0.189 +/- 0.320; mercury, 0.176 +/- 0.114; and cadmium, 6.698 +/- 9.215. Variations in heavy metal concentrations in deer collected from differing ecoregions within Oklahoma are discussed.

Age Factors↗