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Biomedical subjects

W C Dick

Publications and source records attributed to W C Dick.

At least 91 records · Page 5Linked to original sources
PubMed1975

The association between HL-A antigens ankylosing spondylitis and sacro-iliitis.

The second series antigen W27 has been found to have an increased frequency in ankylosing spondylitis (82 per cent of 17 patients) and juvenile rheumatoid arthritis (Still's disease) (29 per cent of 24 patients). Three family studies are presented, including one in which the antigen W27 occurs both in the absence and the presence of ankylosing spondylitis. It is suggested that this family illustrates that the relationship between W27 and sacro-iliitis is affected by non-HL-A genes. The development of clinical disease depends upon the coincidence of several factors in one individual, some of which are genetically controlled by two or more loci which are not necessarily linked.

Adolescent↗
PubMed1975

Liver disease in rheumatoid arthritis and Sjøgren's syndrome. Prospective study using biochemical and serological markers of hepatic dysfunction.

Inter-relationships of biochemical and immunological tests of liver function have been studied in a prospective study of 216 patients with rheumatoid arthritis (RA), 32 patients with Sjogren's syndrome, and 27 patients with the sicca syndrome, and these results have been compared with those obtained 289 patients with osteoarthrosis or with a form of seronegative polyarthropathy. In general the prevalence of abnormalities in serum alkaline phosphatase, bromsulphthalein excretion, smooth muscle antibody, and mitochondrial antibody in the former three groups was higher than in patients with osteoarthrosis. Patients with Sjogren's syndrome with RA had a higher prevalence of abnormalities of bromsulphthalein excretion, salivary duct antibody than patients with the sicca syndrome. Patients with RA had a higher pervalence of rheumatoid factor than those with the sicca syndrome. Patients with a positive smooth muscle or mitochondrial antibody were found to have a higher prevalence of hepatomegaly and splenomegaly, of abnormal liver function tests, of other autoantibodies, and of histological abnromalitis of liver than those in whom these tests were negative.

Aged↗
PubMed1975

Relationship between haemoglobin and the other clinical and laboratory parameters in rheumatoid arthritis.

A retrospective study is reported of 160 patients with definite or classical rheumatoid arthritis, in which changes in haemoglobin concentration were analysed against changes in various routine clinical and laboratory indices of disease activity over a period of time. Although statistically significant correlations were found between haemoglobin concentrations and the articular index of joint tenderness, serum albumin concentration, and erythrocyte sedimentation rate at one point in time, significant relationships in changes in haemoglobin concentration were only found with changes in the latter two laboratory indices. The significant correlations were weak and less important than the cumulative effect of unknown variables in determining haemoglobin level. The study shows that the routine clinical and laboratory parameters of disease activity in rheumatoid arthritis are of no value in predicting the haemoglobin concentration.

Adult↗
PubMed1975

Zinc: its relationship to osteoporosis in rheumatoid arthritis.

Preliminary studies indicate that plasma zinc concentrations, as estimated by atomic absorption spectrophotometry, are reduced in rheumatoid arthritis. A relationship has also been established between metacarpal index of osteoporosis and plasma zinc concentrations in rheumatoid subjects.

Adult↗
PubMed1975

Cell-mediated immunity in the rheumatoid diseases. I. Skin testing and mitogenic responses in sero-negative arthritides.

Cellular immunity has been investigated in patients with various kinds of sero-negative arthritis. The incidence of cutaneous response to recall antigen streptokinase-streptodornase (SK-SD), and the ability to mount a primary cutaneous response to dinitrochlorobenzene (DNCB) have been examined in patients with ankylosing spondylitis and psoriatic arthritis. The results were not significantly different from normal. In vitro lymphocyte transformation in the presence of phytohaemagglutinin (PHA), concanavalin A (Con A), and pokeweed mitogen (PWM) has been measured using peripheral blood lymphocytes from patients with ankylosing spondylitis, psoriatic arthritis and Reiter's disease. In comparison with a control group, significantly reduced responses were found to a low dose of PHA in the ankylosing spondylitis and Reiter disease patients. Significant increase in response occurred to a high dose of PHA, in patients with psoriatic arthritis and Reiter's disease, and to PWM in Reiter's disease patients. The in vitro results in the ankylosing spondylitis, psoriatic arthritis and Reiter's disease patients suggest some abnormality in the T-cell population in sero-negative arthritis.

Adult↗