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Biomedical subjects

W C Chew

Publications and source records attributed to W C Chew.

5 recordsLinked to original sources

Computation of electromagnetic fields for high-frequency magnetic resonance imaging applications.

A numerical method is presented to compute electromagnetic fields inside a 2 mm high resolution, anatomically detailed model of a human head for high-frequency magnetic resonance imaging (MRI) applications. The method uses the biconjugate gradient algorithm in combination with the fast Fourier transform to solve a matrix equation resulting from the discretization of an integrodifferential equation representing the original physical problem. Given the current distribution in an MRI coil, the method can compute both the electric field (thus the specific energy absorption rate (SAR)) and the magnetic field, also known as the B1 field. Results for the SAR and B1 field distribution, excited by a linear and a quadrature birdcage coil, are calculated and presented at 64 MHz, 128 MHz and 256 MHz, corresponding to the operating frequencies of the 1.5 T, 3 T and 6 T MRI systems. It is shown that compared with that at 64 MHz, the SAR at 128 MHz is increased by a factor over 5 and the SAR at 256 MHz is increased by a factor over 10, assuming the same current strength in the coil. Furthermore, compared with the linear excitation, the average SAR for the quadrature excitation is reduced by a factor over 2 and the maximum SAR is reduced by a factor over 3. It is also shown that the B1 field at high frequencies exhibits a strong inhomogeneity, which is attributed to dielectric resonance.

Algorithms

Variable density linear acoustic inverse problem.

The linear acoustic inverse problem is solved simultaneously for density (rho) and compressibility (kappa) using the basic ideas of diffraction tomography (DT). The key to solving this problem is to utilize frequency diversity to obtain the required independent measurements. The receivers are assumed to be in the far field of the object, and plane wave incidence is also assumed. The Born approximation is used to arrive at a relationship between the measured pressure field and two terms related to the spatial Fourier transform of the two unknowns, rho and kappa. The term involving compressibility corresponds to monopole scattering and that for density to dipole scattering. Measurements at several frequencies are used and a least squares problem is solved to reconstruct rho and kappa at the same time. It is observed that the low spatial frequencies in the spectra of rho and kappa produce inaccuracies in the results. Hence, a regularization method is devised to remove this problem. Several results are shown. Low contrast objects for which the above analysis holds are used to show that good reconstructions are obtained for both density and compressibility after regularization is applied.

Acoustics

Influence of simultaneous low amniotomy and oxytocin infusion and other maternal factors on neonatal jaundice: a prospective study.

In a prospective study of 196 consecutive single births a significant increase in serum bilirubin concentrations was found in infants born after low amniotomy induction and oxytocin infusion compared with those born spontaneously. This relationship was not dose-dependent and may have been associated with artificial interruption of pregnancy rather than the oxytocin itself. Infants delivered after spontaneous labour accelerated by oxytocin showed no such increase. The hormonal surge at the spontaneous onset of labour may affect fetal enzyme induction, but other factors, such as methods of infant feeding and oral contraceptive use, were found not to be significant.

Bilirubin