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Biomedical subjects

W C Chen

Publications and source records attributed to W C Chen.

At least 181 records · Page 10Linked to original sources
PubMed1979

Regression of Hodgkin disease in the mediastinum: a mathematical model.

Twenty-seven patients with mediastinal Hodgkin disease were teated either by radiation therapy or chemotherapy. The rates of tumor regression were measured and were fitted into a three-parameter Gompertzian model. Tumor regression was more pronounced and prompt in patients treated with radiotherapy. The Gompertzian model matched the radiation therapy data closely in the first 90 days after initiation of therapy in cases of approximately equal tumor size.

Evaluation Studies as Topic↗
PubMed1979

Induction of colitis in hamsters by topical application of antibiotics.

Syrian hamsters are exquisitely sensitive to clindamycin; as little as 1 mg/kg of clindamycin given systemically causes a fatal colitis. Clindamycin and erythromycin were applied topically daily to the shaved backs of Syrian hamsters in a hydroalcoholic vehicle. A daily dose of 0.1 mg of clindamycin was lethal to more than half the hamsters and 1 mg to all the animals. The antibiotic-associated toxin from Clostridium difficile was present in their cecal material. Based on body surface areas and estimated usual volumes applied, the lethal dose in hamsters is not dissimilar to that given humans for acne. Oral tetracycline therapy protected the animals from clindamycin toxicity, but the animals died three days after stopping tetracycline if topical clindamycin applications were continued.

Administration, Topical↗