Epidemiology and control of St. Louis encephalitis in Birmingham, Alabama, 1975.
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Biomedical subjects
Publications and source records attributed to W C Bailey.
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For most tuberculin reactors, chest radiographs are obtained at the beginning of, at various intervals through the course of, and at the end of the year of isoniazid preventive therapy. A study of 1,524 tuberculin reactors was performed to determine the value of chest radiographs obtained after therapy was begun; 1,315 had normal radiographs at the beginning and end of therapy, and 209 had radiographic abnormalities at both times. No significant changes were noted in any of the 1,524 patients' radiographs. Similar results had been reported for 551 tuberculin reactors in an earlier study. This provides a total of 2,075 patients for whom no value could be found in the subsequent radiographs. We found no value in repeating normal chest radiographs of positive reactors if they had completed at least 9 months of the properly recommended 12 months of isoniazid preventive therapy. The lack of value of repeat radiographs, coupled with their fixed cost and the potential risk of unnecessary radiation, dictated our change in policy--we no longer repeat normal chest radiographs in such persons.
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Six patients with immature teratoma of the ovary were treated with surgery and chemotherapy. Surgical management consisted of unilateral salpingo-oophorectomy, biopsy and conservation of the contralateral ovary, and biopsy of peritoneal implants. Triple-agent chemotherapy with vincristine, actinomycin D, and cyclophosphamide was given to four patients and appeared to be beneficial. Radiation therapy was not employed. Local resection of teratomatous recurrences was frequently necessary. Thorough sampling of this tumor is mandatory for establishment of an exact pathologic diagnosis. All six patients are surviving in good health at 1-8-yr follow-up. The prognosis of immature teratoma in the child or adolescent appears more favorable than previously appreciated.
Eleven cases of hamster associated lymphocytic choriomeningitis occurred within a space of four months in Jefferson County, Alabama residents. A single Birmingham breeder was the source of the infected hamsters. Ten cases experienced an illness of one to three weeks duration with grippe-like symptoms being most frequent. Complaints of nine cases suggested meningeal involvement, and one was asymptomatic. All patients recovered uneventfully. Frequent hamster contact had occurred in most cases, although three individuals reported infrequent or room exposure to the animals. The holding of hamsters for observation prior to sale, random testing of all breeders' stock, and the distribution of printed information with each hamster sold are suggested as precautions against future outbreaks of this nature.
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A study was made to determine whether the ingestion of isoniazid interfered with the colormetric reaction used in most autoanalyzers to measure serum glutamic oxaloacetic transaminase (SGOT). Colormetric (autoanalytic) and noncolormetric (enzymatic) measurements of SGOT were made on a venous blood sample from each of 100 hospital employees who were taking isoniazid to prevent tuberculosis. The 2 techniques of measuring SGOT yielded comparable results. It was concluded that autoanalytic (colormetric) measurements of SGOT in isoniazid recipients are reliable.
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