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Biomedical subjects

W Buchberger

Publications and source records attributed to W Buchberger.

84 records · Page 5Linked to original sources
PubMed1990

[Sonography in breast diagnosis].

In a prospective study of 235 tissue masses verified histologically, we examined the diagnostic contribution of ultrasound in comparison to mammography. When the two methods were combined, 96.8% of all malignant neoplasms could be diagnosed correctly. Most (90.5%) were found by mammography alone and 4.8% were detectable by ultrasonography but not by mammography. Despite relatively good results in the evaluation of solid masses, it is not advisable to omit tissue examination. The superiority of ultrasound over mammography in the diagnosis of cystic lesions could lead to a significant reduction in needle aspirations and biopsies.

Adenofibroma↗
PubMed1989

Alumina as stationary phase for ion chromatography and column-coupling techniques.

Columns packed with alumina were combined with common anion-exchange columns and applied to the ion chromatographic determination of sulphate in brines and biological fluids and for the trace determination of iodide in mineral waters and fruit juice samples. Alumina was found to be a highly selective stationary phase for the preconcentration of sulphate from complex matrices. Further, owing to its selectivity, which is different from that of R4N+-type anion-exchange materials, it is well suited for on-line column-coupling techniques. In this way sample clean-up can be minimized, and the sensitivity of the chromatographic system allows determinations of iodide down to the low ppb range.

Aluminum Oxide↗
PubMed1989

[The peroxidase content of human tears].

The peroxidase-(POD)-thiocyanate-hydrogenperoxide-system is a well-known antibacterial system, which has been demonstrated to exist, for example, in milk and saliva. Earlier investigations by van Haeringen et al. established a POD level in human tears of 10(3) units/l, yet the thiocyanate concentration was only about 0.2 mmol/l. Therefore van Haeringen et al. excluded the existence of a POD-thiocyanate-hydrogenperoxide antibacterial system in human tears because of the insufficient amount of thiocyanate in the tears examined. Instead of thiocyanate halides such as J- can also complete the POD hydrogen peroxide system as electron donors. Sufficient amounts of iodide can be expected after the application of iodine-containing eye drops or after local treatment with iodine-containing brine, as done in Bad Hall in Austria. Therefore, the above mentioned antibacterial system may be of importance if the POD-level is high enough (greater than 250 units/l). We investigated 22 tear samples from healthy persons: the POD levels were below 20 units/l in 19 cases; in 3 cases the POD concentration was found to be between 20 and 50 units/l. Therefore, in normal human tear fluid, not only the amount of thiocyanate but also the concentration of POD is too low for effective antimicrobial activity of the peroxidase-thiocyanate-hydrogenperoxide system. It is so far not known whether this system is effective under pathological conditions.

Adolescent↗
PubMed1988

Investigations into lactoperoxidase-catalysed bromination of tyrosine and thyroglobulin.

Thyroid peroxidase and lactoperoxidase are capable of producing oxidized bromine species. Thus investigations into bromination reactions with tyrosine and thyroglobulin were undertaken in order to gain insight into possible formation of brominated thyroid hormone analogues. A reversed-phase high-performance liquid chromatographic method was developed for the separation of bromine/iodine-substituted tyrosines and used as a basis for these investigations combined with ultraviolet absorption and electrochemical detection. The results indicate that in vivo bromination of tyrosyl residues in thyroglobulin might be of some importance in cases of either iodine deficiency or excessive bromide intake.

Bromine↗
PubMed1988

Determination of iodide and bromide by ion chromatography with post-column reaction detection.

During an investigation into the mechanism of the biosynthesis of thyroid hormones, it became necessary to determine traces of iodide and bromide in biological matrices as well as in food. A vydac 302-IC anion-exchange column with methanesulphonic acid as the mobile phase was used for the ion chromatographic separation of iodide and bromide. A post-column reaction detector was developed based on the reaction between iodide or bromide, chloramine-T and 4,4'-bis(dimethylamino)diphenylmethane. Methods with minimal sample preparation are described for determination of iodide or bromide in serum, milk, salt and water. The detection limit is ca. 20 pg iodide and 15 ng bromide injected.

Animals↗
PubMed1988

Site preference of metastatic tumours of the brain.

Amongst 15,000 autopsies performed between 1969 and 1984 in the Department of Pathology of the University Hospital of Innsbruck (Austria) 237 cases (1.6%) with brain metastases were found. The mean age of patients was 61.2 years and 148 patients out of 230 cases with satisfactory records were male (64.3%). Multiple lesions were found in 58%. In absolute figures carcinoma of the lung, followed by malignant melanoma and breast carcinoma were, as in other series, the most frequent primary site for brain metastases. The relative frequency of brain metastases in various anatomical regions of the brain showed that malignant melanoma tends to metastasize to the frontal and temporal lobes, breast carcinoma to the cerebellum and the basal ganglia, large cell carcinoma of the lung to the occipital lobe and squamous cell carcinoma of the lung to the cerebellum. Metastases of small cell carcinoma of the lung were found equally distributed in all regions of the brain. Our study supports the results of several experimental investigations, suggesting the possibility that specific cell surface properties of metastasizing tumour cells and particular properties of the vascular endothelium of the target organs of metastasis are responsible for the location of metastases. The results of this study suggest that there are substantial differences in regard to these properties even within one target organ.

Adult↗
PubMed1987

[Urinary iodine excretion in Austria and the effect of iodine balneotherapy].

Urinary iodine excretion was examined in 645 patients at Bad Hall, both before and after undergoing iodine balneotherapy. The results indicate that in spite of iodized salt prophylaxis there is still an insufficiency of iodine supply in Austria. No essential differences were detected between individual regions of Austria. After completion of various types of iodine balneotherapy each lasting four weeks, the iodine excretion of all patients was higher than the minimum value proposed by WHO.

Austria↗
PubMedDate not supplied

MR-imaging of post-traumatic olivary hypertrophy.

We present clinical and magnetic resonance (MR) findings in 83 patients with inner cerebral trauma (ICT). In addition to the ICT-related lesions, uni- or bilateral enlargement and signal abnormalities of the inferior olivary nucleus were detected by MR in 9.6% of patients as a consequence of lesions within the dentato-rubro-olivary pathway. Clinically, segmental myoclonias were present in five patients. These observations suggest that MR imaging is highly sensitive in the detection of olivary hypertrophy and of causative traumatic lesions of the dentato-rubro-olivary pathway.

Adolescent↗