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Biomedical subjects

W Brosig

Publications and source records attributed to W Brosig.

At least 19 recordsLinked to original sources
PubMed1986

Bilateral testicular germ cell tumors. Report of nine cases and review of the literature.

In a series of 181 patients with testicular germ cell tumors, the phenomenon of bilateral involvement of the testicles was observed nine times (5%). Two patients evidenced a simultaneous bilateral tumor, and, in seven others, a second tumor occurred after an interval ranging between 8 months and 6 years and 11 months. The incidence, histologic findings, therapy, and prognosis of bilateral testicular tumors are discussed on the basis of a survey of the literature. Emphasis is placed on the significance of a long-term follow-up period as well as on the important role of sonography in the early detection of a contralateral tumor.

Adolescent↗
PubMed1978

[Autologous human skin flaps in partial replacement of bladder wall (author's transl)].

Untreated autologous compound skin (Rehn's skin flap) was used in three patients for partial replacement of the urinary bladder wall. The early postoperative results regarding the general tendency of the healing process, primary density, capacity, and functional voiding of the bladder correspond with an ideal replacement of the bladder wall. Observations of long-term controls will be reported later.

Aged↗
PubMed1977

Preoperative irradiation of renal cell carcinoma.

Since 1967 we have been using preoperative radiation therapy for renal cell carcinoma as proposed by Riches. Radiation therapy, to include the para-aortic lymph nodes, is given in 250-rad increments four times weekly to a total dose of 3,000 rads. After an interval of three weeks following radiation therapy, we performed radical nephrectomy. The object of this preoperative treatment is devitalization of growing cells in the periphery of the tumor, thus preventing metastases and local recurrence, and and decreasing the size of the tumor and thereby facilitating surgery. In one third of the cases there is radiologically demonstrable decrease in the size of the tumor, probably secondary to obliteration of the dilated veins in the capsule. The delay of six weeks has had no adverse effect on the outcome of metastases.

Adenocarcinoma↗
PubMed1977

[Irradiation for prevention of gynecomastia prior to estrogen therapy in cases of carcinoma of the prostate (author's transl)].

The most frequent and most unpleasant side-effect of therapy with estrogen hormones in patients with carcinoma of the prostate is the painful gynecomastia. Since 1969, we have been performing the prophylactic irradiation of the mammary glands on 284 patients in order to prevent a hormone-induced gynecomastia. The majority (262 patients) was irradiated with 600 rad surface dose in fractions of 150 rad prior to the hormone therapy. One hundred and two patients, having been treated endocrinologically for 2-75 months, had a follow-up examination. After irradiation, only 19% of the patients did not develop a gynecomastia, and 60% had no mamillary hyperesthesias. Compared to other authors, the therapy was less efficient, the symptoms, however, were discrete. As a consequence, an increase of the radiation dose as well as an alteration of the fractionation must be used.

Aged↗
PubMed1977

[Experiences with various antireflux operations (author's transl)].

One hundred and thirty-eight antireflux operations in 94 patients are reported from 1964 to 1974. Bischoff's method was used 44 times with 63% successful results; Lich/Grégoir's method 38 times with 77% success; and Politano/Leadbetter's method 50 times with 92% success. Indications are briefly investigated.

Evaluation Studies as Topic↗
PubMed1976

Investigations of urinary stone formation following persorption.

Persorption is the excretion in urine of particles that have been absorbed (persorbed) from the gastrointestinal tract. In experiments with rats the effect of Herbst was combined with the production of renal calcium oxalate sediments by the oral administration of ethylene glycol and acidification with ammonium chloride. We used this method to investigate whether persorbed corpuscula may represent nuclei of crystallization in the formation of renal calculi. Lead sulfide, zirconium silicate and 45Ca-labeled calcium oxalate crystals were used as persorbable model bodies. It became apparent that orally supplied lead sulfide and zirconium silicate crystals could be found in the urine and the kidneys but they did not function as crystallization centers in the calcium oxalate sediments. However, radioactive labeled calcium could be demonstrated histoautoradiographically within the renal concrements. Our experiments showed that persorbed calcium oxalate crystals can work as nuclei for stone formation.

Ammonium Chloride↗
PubMed1976

[Preoperative irradiation in hypernephroid carcinoma].

Since 1967 we have been using preoperative radiation therapy for hypernephroma as proposed by RICHES. Radiation therapy, to include the para-aortic lymph nodes, is given in 250 rad increments 4 times weekly to a total dose of 3000 rads. After an interval of 3 weeks following the radiation therapy, we are performing the radical nephrectomy. 100 patients were treated by this method in the years 1967-1975: 32 patients were in stage I, 7 in stage II, 50 in stage III and 11 patients in stage IV. In 26 patients more than 5 years have passed since the beginning of the treatment: 46% od these survived. The survival for 3 years is 63, for 1 year after the surgery 80%. The surgical mortality rate is 2%. The object od the preoperative treatment is: 1. Devitalization of growing cells in the periphery of the tumor, thus preventing metastases and local recurrence. 2. Decreasing the size of the tumor and thereby facilitating surgery. In one-third of the cases there is radiologically demonstrable decrease in the size of the tumor mass, probably secondary to obliteration of the dilated veins in the capsule. The delay of six weeks has had no adverse effect on the outcome of the disease.

Adenocarcinoma↗
PubMed1975

[First experiences with the incontinence operation Kaufman III (implantation of a silicongel prothesis covered with polyurethanfoam) (author's transl)].

For operative treatment of urinary incontinence after TUR of the prostate, radical prostatectomy and meningocele operation the silicongel prothesis described by Kaufman was implanted. By compression of the bulbus urethrae a sealing effect was achieved. The pressure of the detrusor opens the urethra enough to enable urination. Seven patients were operated. The results directly after the operations were: three very good, two good and two bad. We achieved very good results by implantation of the prothesis "large" -in the case of the two bad operative results we used the "medium" size prothesis. By filling these protheses with 5 ml liquid they proved to be leaky. One of these was operatively removed and replaced by the size "large". This patient later developed a urethra stricture in the implantation region with overflow bladder after having been continent. By internal urethrotomy this condition was restored; except for minor dripping after miction the patient was continent. The prothesis of a direct postoperative continent patient had to be filled. This led to and infection with the development of fistula. The prothesis had to be removed. A further patient who sat on a hard object developed a lesion of the prothesis with resulting incontinence. At least six months after the operations four patients remained continent and three incontinent.

Aged↗
PubMed1975

Experimental urinary stone formation following persorption.

The 'effect of Herbst' was combined with the production of renal calcium oxalate sediments by oral administration of ethyleneglycol and acidification with NH4Cl. This investigation was made to see whether persorbed bodies may form nuclei in crystallization in the genesis of stone. Lead sulphide crystals and 45Ca-labelled calcium oxalate crystals were used as persorbable model bodies. It became apparent that lead sulphide crystals given by mouth could be found both in the urine and kidneys, but these did not form nuclei in calcium oxalate sediments. Radioactive-labelled calcium, however, could be proved histoautoradiographically within the renal concretions. Our experiments showed that persorbed calcium oxalate crystals can represent nuclei for stone formation.

Ammonium Chloride↗