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Biomedical subjects

W Bischoff

Publications and source records attributed to W Bischoff.

At least 55 records · Page 3Linked to original sources
PubMed1977

[The problem of surgical therapy of malignant kidney tumors].

Critical examination of the results of surgical treatment and new surgical techniques have produced changes in the operative treatment of hypernephroid kidney cancer and nephroblastoma. The limits to operative treatment are, first, the local extension and infiltration of the tumor and, second, the grade and degree of metastases. Surgical removal of the hypernephroma seems to have a positive effect on metastasis regression only in the case of bone metastases. Nephrectomy is indicated only in cases with solitary metastases which can be removed at a second operation. The possibility of arterial embolization in renal hemorrhage in inoperable patients is demonstrated. Current aspects of the operative treatment of nephroblastoma are discussed.

Bone Neoplasms↗
PubMed1977

[Correlation between microangiography and histological findings in renal carcinomas (author's transl)].

Arterial, venous and simultaneous arterial and venous injections with radio-opaque dyes were carried out under manometric control on three renal cell carcinomas following nephrectomy. The micro-angiographic appearances were then correlated with the histological findings. The radiologically abnormal vessels correspond with sinusoids with thin, capillary-like walls containing localised areas of thickening in a collagen-rich stroma. Both micro-angiographically and histologically, the sinusoidal connections can be demonstrated between the edge of the tumour and normal tissue. Arterio-venous anastomoses were not found. The angio architecture and micro-angiographic pattern in renal cell carcinomas is described. The significance of these changes in the circulation is discussed and its significance in carrying out pharmaco-angiography and retrograde phlebography is pointed out.

Adenocarcinoma↗
PubMed1977

[Efficacy of experimental renal embolization with microspheres. Additionally, a critical report on the complication rate of intra-arterial embolization with particles (author's transl)].

Renal embolization was performed in 12 dogs using the Seldinger technique and microspheres 250 +/- 40 micrometer in diameter. Periodical arteriography, microangiographies and histological analysis was carried out to control the efficacy of embolization. As a result, renal arteries could be embolized wi. th microspheres, however, because of statistical distribution there were histologically anemic and normal parenchyma situated closely together. In more than 50% there was a reflux of microspheres which could only be detected by histological examination, while angiographies showed a totally normal vascular pattern. Microspheres should not be used in clinical embolization. Experimental investigation of embolization materials must almost embrace histological analysis.

Animals↗
PubMed1977

[The influence of renal artery occlusion on tumor growth of experimental nephroblastomas (author's transl)].

Nephroblastomas are induced in rats with N-Methyl-N-Nitroso-Urea, and selective renal artery occlusion is performed. This procedure has the same effect like occlusion by embolization. The effect of renal artery occlusion on the growth rate of nephroblastmas is controlled by angiography and gross and microscopic examinations up to 70 days following ischemia, the results are compared with a group of untreated nephroblastoma rats. There is a marked reduction of tumor size and a decrease in tumor proliferation. There is an immediate tumor cell death induced by acute and complete ischemia. Collateral blood vessels cause residual arterial blood supply of tumor parenchyma. There seems to be a correlation between collateral blood delivery and tumor size. Even 70 days after permanent ischemia there are areas of obviously absolute normal tumor cells. The conclusion of this experimental study demonstrated that growth rate of tumors can be reduced by ischemia although potentially malignancy still remains. Clinical embolization therapy is justified only in nonoperable patients with hypernephroma and with massive hematuria.

Animals↗
PubMed1977

[Balloon occlusion of the renal artery in operative urology (author's transl)].

A double lumen Swan Ganz balloon catheter is introduced percutaneously into the renal artery. Temporary and repeated occlusion of the artery by inflation of the balloon are combined with hypothermic perfusion of the kidney. Thus extensive nephrolithotomies can be done without time limit as in warm ischemia. The operation field is blood-less and the parenchym is protected by perfusion. There is no need for pedicle dissection or external cooling. One complication is seen when the catheter is slipping out of the artery in cases of short renal arteries and the patient is in an extremely bent operation position for intercostal approach. Ballon occlusion without perfusion is helpful in tumor nephrectomy. Preoperative embolization is not necessary when this technique is used. Embolization means an additional procedure with further complications.

Adenocarcinoma↗
PubMed1977

[Successful intra-arterial embolization of bleeding carcinoma of the prostate (author's transl)].

The very first case of successful therapeutic embolization for hematuria from carcinoma of the prostate is presented. In a 76-year-old patient with necrotic carcinoma of the prostate, stage D transurethral operations showed no success. By selective intra-arterial embolization via the internal iliac arteries (using Gelfoam), hematuria could be stopped definitely and did not occur any more. Follow-up study showed no complications or necrosis in this procedure.

Aged↗
PubMed1976

[Surgery of malignant kidney tumors].

Critical examination of the results in surgical treatment and new surgical techniques have lead to some changes in operative therapy of hypernephroid kidney cancer. Indications for surgical treatment and different operative techniques are described in dependence of grade of metastases. The possibility of arterial embolization in renal hemorrhage in inoperable patients is discussed.

Embolism↗
PubMed1976

[Modified in situ perfusion of the kidney using balloon catheters].

Experiences with the in situ hypotherme perfusion in the operative treatment of calculus in kidneys and calices are reported. A modified technique is presented using an inflatable Swan-Ganz-ballon catheter for simultaneous blocking of renal blood flow and perfusion.

Adult↗
PubMed1976

[Evaluation of experimental arterial occlusion, with special reference to its complications (micro-spheres, Histo-Acryl, Paladur, alternating and direct currents (author's transl)].

Permanent arterial occlusion can be obtained experimentally by using plastic micro-spheres, polymerising materials (Histo-Acryl, Paladur) and direct current thrombosis. Certain limitations in their use arise from the properties of the substances. In our experience, plastic microspheres are not suitable for blocking entire organs or large vascular territories. They are more appropriate for occlusion of individual, small vessels by super-selective injections. Sole use of polymerising materials is not possible; they are best used in combination with other techniques (magnets, balloon catheters). Induction of thrombosis by small direct currents (50 volt, 10 mA). produces permanent and complete occlusion. The method can be used selectively or super-selectively. Unwanted thrombosis can be avoided by using catheters with the smallest possible external diameters.

Acrylic Resins↗