[The concept of cervical intraepithelial neoplasia].
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Biomedical subjects
Publications and source records attributed to W Beckert.
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124 autopsy cases with acute pulmonary embolism were investigated. Severe or moderate necrosis of parenchymal cells were found in 24%, and disseminating microfocal necrosis furthermore in 32%. An unsignificant or mild cholestasis was observed in 44%. The cause of necrotic liver damage is a complex circulatory disturbance, formed by acinar liver structure. A correlation between degree of thromboembolism and liver necrosis or cholestasis does not exist.
An account is given in this paper of 102 cases of appendectomy in parellel with 193 gynaecological laparotomies (52.9 per cent), with reference being made to the small amount of associated complication, as borne out by literature data on larger groups of patients. Particular reference is made, in that context, to legal and clinical prerequisites and to counter-indictions. The authors' own pathohistological findings differed from figures around 90 per cent, as reported elsewhere, in that more or less conspicuous tissue peculiarities were recorded from only 37.5 per cent of all simultaneously removed appendices. That discrepancy in evaluation is discussed. With the relative increase in incidence and complication of senile appendicitis in mind, appendectomy in parallel with gynaecological laparotomy is recommended as a genuine prophylaxis, yet, with due consideration of all necessary conditions.
For the differentiation of the disturbances of the uric acid metabolism the determination of the uric acid clearance is a valuable help. A normal clearance (greater than or equal to 0.116 ml/s, 7 ml/min) in hyperuricaemia speaks for an overproduction of uric acid (type I), a decreased clearance (less than or equal to 0.100 ml/min) speaks for a disturbance of the renal excretion (type II). By additional parameters which are simply to be got further subtypes (Ia, Ib, IIa, IIb, III) can be delimited. All examinations can be performed under ambulatory conditions. On the basis of this division the antihyperuricaemics may be better used. The application of the drugs according to types favours the decrease of the side-effects of the drugs and additionally shows economic advantages.
In a series of 800 unselected autopsy cases in 46 patients gastric myomas were founded. These tumors are the most common non-epithelial neoplasms of gastric wall. The average age runs to 77 years. Myomas are mainly localized in the fundus and corpus of the stomach. They originate from the internal layer of the muscularis propria. These myomas grow very slowly, and calcification or sclerosis are frequent. The practical clinical importance is insignificant.
The participation of the myocardium in sarcoidosis is a severe complication which in very rare cases may lead to the acute cardiac death. Morphological problems result from all accessory cardiac changes.
It is reported on an up to now not described combination of bronchial carcinoma and multiple amyloid tumours of the lung as autopic side findings in a 68-year-old patient.
Three own observations of oscillating miniature lipomas of the epicardium are a cause to doubt the extreme rareness of this form of tumours. Pediculation and vascular proliferations facilitate the morphological delimitation of fat rumps. The possibility of a removal of infarcted lipomas of the epicardium is taken into consideration.
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The so-called adenomyomas of the stomach in the antric region can often be seen. However, cystic alterations including duplications are a rarity. The author reports on a case of a duplication of the stomach in connection with a so-called adenomyoma of the pyloric channel. On the basis of a case report he describes morphogenesis, clinical aspects, complications and therapy with due consideration of the literature.
In a series of 500 unselected autopsy cases 23 myomas, 14 neurinomas and 5 lipomas of the stomach were met. Benign tumours are mainly localized in the corpus and fundus of the stomach.
A brief report on endometrium carcinoma with lung metastases is given. The obturation of the main bronchus and trachea by lymphonodular metastases is a rare cause of death.
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By intensive investigation relatively often small lipomas in the duodenum can be found at post mortem examination. They are harmless and develop in the submucosa and grow in a polypous form into the lumen. Lipomas seem to be the most frequent among the benign mesenchymal tumours.
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A brief report an lung metastases of a malignant giant cell tumour simulating an alveolar cell carcinoma in peripheric regions is given, and a critical classification of alveolar cell carcinoma is supported.
It is reported on a rare endobronchial lipoma, which was falsely interpreted and the radiological course of which was more than 15 years. It is referred to the discrepancy between morphological benignity of the lipoma and the dangerous changes of the lungs when the disease is delayed.