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Biomedical subjects

W Baumgartner

Publications and source records attributed to W Baumgartner.

At least 109 records · Page 6Linked to original sources
PubMed1981

Challenge of penicillin-allergic volunteers with penicillin-contaminated meat.

In order to obtain information about the clinical course and immunological background of possible allergic reactions due to penicillin-containing food, nine volunteers with penicillin allergy proved by case history, positive skin tests and/or positive penicilloyl-specific RAST were exposed to penicillin-contaminated pork. For this purpose a farm pig from an inbred strain received "therapeutic" doses of benzyl procain penicillin before being slaughtered. Meat samples were taken from muscle tissues, kidney and liver and analyzed by diffusion and extraction methods. Very small amounts of penicillin were detectable in muscle tissue, whereas kidney material contained up to five times as much (0.12 mcg/g). Except two cases which reacted with itchy sensations after ingestion of penicillin contaminated meat "á la tartare", all probands were clinically free of symptoms. Assaying penicilloyl-specific IgE antibodies by RAST during the trial, a tendency to increased levels in the serum after 2 and 24 h was noted, whereas the titers of BPO-specific IgG antibodies measured by the red cell-linked antigen-antiglobulin reaction (RCLAAR) remained unchanged. It is concluded from this study that small and hidden amounts of penicillin and its derivatives in food seldom induce anaphylactic reactions in penicillin allergic patients.

Adult↗
PubMed1980

Treatment of anorchia with oral testosterone undecanoate: pharmacodynamics and clinical effectiveness.

The pharmacodynamics of plasma testosterone (T) and androstenedione (A) levels were studied in ten hypogonadal boys after oral administration of testosterone undecanoate (TU). Plasma T and A levels were measured by specific radioimmunoassays. Six hours after a single dose of 120 mg TU, there was a significant increase (P < 0.005) in plasma T and A with a median T peak level of 940 ng/100 ml. Furthermore, twelve agonadal boys treated with a mean dose of 60 mg TU/day were examined over a period of 18-24 months. During this therapy, plasma T and A levels were significantly higher than before (P < 0.005), whereas plasma levels of LH and FSH did not decrease significantly. With the exception of one anorchic boy, all patients showed signs of sexual maturation, such as growth of pubic and axillary hair, and steady development of bone age during oral TU treatment.

Administration, Oral↗
PubMed1976

Fluoride content of dental hard tissues with special respect to fluoridation of domestic salt.

Teeth from children with various histories of fluoride supplementation were collected and analysed for fluoride. Fluoride concentrations in dentine from the canton of Vaud with fluoridated salt at 250 ppm since 1969 were at a level comparable to that reported from regions with 1.0 ppm F- in the drinking water and in children having received fluoride tablets during their tooth formative age.

Child↗
PubMed1975

Protein sulphydryl depression during adjuvant arthritis.

The changes in plasma protein sulphydryl level were measured during the course of adjuvant-induced arthritis in rats. Major depressions in the plasma sulphydryl level occurred at the onset of adjuvant disease, and the extent of the depression was related to the severity of the disease. Plasma sulphydryl levels remain unchanged when the systemic arthritis is suppressed by inclusion of a competing antigen in the adjuvant. Changes in sulphydryl content of the plasma were shown not to be due to weight loss or decrease in plasma protein level.

Animals↗
PubMed1975

[Late results from patients with operated primary hyperparathyreoidism (mainly renal manifestation) (author's transl)].

By means of folow up of patients with operated primary hyperparathyreoidism (mainly renal manifestation) therefore neck exploration should be done on a broader scale and also the late results are reported. They indicate that a carefully considerated neck exploration is relatively free of risk. Of permanent postoperative complications in 83 operations made upon 76 patients only one case of a permanent unilateral paralysis of the recurrent laryngeal nerve was observed. The patients were subjectively free of symptoms; in the successfully operated patients stone recurrence or increase respectively growth of already existing urinary stones did not occur postoperatively. Those patients in whom repeatedly renal stones had been evident at the time of the operation, reported increased colics with partly spontaneous discharge of stones shortly after the operation; the i.v.p. controls showed no recurrent or additional formation of urinary stones in the patients, where we did successful neck exploration. The comparisons of the pre- and postoperative calcium levels indicate that the aim of the operation, normalisation of the calcium metabolism was obtained in almost all cases; only in 3 patients a hypercalcaemia remained. Mediastinotomy was performed only for two times. From these follow up we conclude that neck exploration carries a little risk compared to the high morbidity of primary hyperparathyreoidism (renal manifestation). Therefore neck exploration should be done on a broader scale and also in cases of diagnostic borderline values.

Adult↗