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Biomedical subjects

W Bateman

Publications and source records attributed to W Bateman.

8 recordsLinked to original sources
PubMed1995

Spatial disorientation-implicated accidents in Canadian forces, 1982-92.

In a recent survey of CF18 aircrew human factors, 44% of pilots reported experience with spatial disorientation (SD), of whom 10% had experienced more than 3 episodes. In order to investigate further, we have completed a retrospective study of SD-implicated category A accidents (where an aircraft is destroyed, declared missing, or damaged beyond economic repair) in the Canadian Forces (CF) during 1982-92. An overview of all SD occurrences (including accidents and incidents) across aircraft types is also presented. Information was gathered concerning the genesis and severity of disorientation so that research effort and pilot training could be appropriately implemented. Mishap investigation summaries involving category A accidents where SD was implicated were obtained from the CF Directorate of Flight Safety and reviewed. We also examined in detail the Board of Inquiry Reports of these accidents. The role of disorientation in these accidents was assessed. There were 62 category A accidents between 1982-92 and, in 14, SD had been assigned as a possible cause factor in the accident records. When divided into the categories of Recognized SD (RSD), Unrecognized SD (USD), and Incapacitating SD (ISD), all but two fell into the category of USD (the pilots were unaware of the disorientation). Of the SD accidents, 11 involved a total loss of 24 lives. The majority of the accidents happened during the day, and pilots' cumulative flying experience did not appear to be a significant factor. According to our assessment, there were two episodes of vestibular origin, involving the somatogravic illusion. Three episodes of disorientation occurred over frozen lakes, one over glassy water, and one over ocean.(ABSTRACT TRUNCATED AT 250 WORDS)

Accidents, Aviation↗
PubMed1993

Interactions between interferon gamma and retinoic acid with transforming growth factor beta in the induction of immune recognition molecules.

The cell-surface expression of major histocompatibility (MHC) antigens and the adhesion molecule intercellular adhesion molecule 1 (ICAM-1) is essential for target cell recognition by T lymphocytes. The expression of both classes of molecule is induced by various cytokines, notably interferon gamma (IFN gamma). Since transforming growth factor beta (TGF beta) has been recently reported to antagonise HLA-DR induction by IFN gamma we have examined, using a number of murine and human cell lines, the effect of TGF beta on IFN gamma-induced MHC class I and class II and ICAM-1 expression. All of the cell lines tested expressed elevated class I MHC following IFN gamma treatment. Class II MHC induction was seen on most but not all of the cells, the exceptions being among a panel of human colorectal carcinoma cell lines. A striking difference between cells of different origin was noted in the response to TGF beta. TGF beta was found to antagonise IFN gamma-induced class I and class II MHC expression on C3H 10T1/2 murine fibroblasts, early-passage BALB/c mouse embryo fibroblasts, a murine oligodendroglioma cell line, and on MRC5 human fibroblasts and two human glioblastoma cell lines. Class II MHC was much more strongly inhibited (sometimes completely) than class I MHC. TGF beta also inhibited induction of class I MHC expression by IFN alpha. However, TGF beta did not inhibit class I or class II MHC induction by IFN gamma in any of the nine colorectal carcinoma cell lines, although two of five of the lines tested were growth-inhibited by TGF beta. On the other hand, human ICAM-1 induction by IFN gamma was not affected by simultaneous treatment with TGF beta in any of the cell lines. The down-regulation of IFN gamma-induced MHC antigens by TGF beta is not, therefore, the result of a general antagonism of IFN gamma. Retinoic acid has recently been reported to induce ICAM-1 expression on human tumour cells. We have confirmed this observation on MRC5, and the two human glioblastoma cell lines, however six colorectal carcinoma cell lines tested did not respond. In contrast to IFN gamma-induced ICAM-1 expression, retinoic-acid-induced ICAM-1 expression was inhibited by TGF beta on two of the three responsive lines.

Animals↗
PubMed1983

Blood flow determination using recursive processing: a digital radiographic method.

Temporal filtration of fluoroscopic video sequences is being used as an alternative to pulsed digital subtraction angiography. Using the same image processing architecture and a slight modification in processing logic a parametric image can be synthesized from such a temporally filtered image sequence in virtual real time, i.e., an image sequence that spans T seconds takes exactly T seconds to process. Off-line computer processing is not required. Initial phantom studies imply that the time to maximum opacification (tmax) can be used to determine absolute and relative blood flow with a high confidence level (r greater than .989). Phantom and animal examples are presented.

Angiography↗
PubMed1982

Digital subtraction angiography using a temporal bandpass filter: initial clinical results.

A dual digital memory recursive filtering system provides an effective alternative to digital subtraction imaging by using routine fluoroscopic equipment operated with slightly elevated fluoroscopic technical factors. This is accomplished with relatively inexpensive portable electronic equipment that can be connected to the video output of most modern fluoroscopic systems. Initial clinical experimental studies suggest that the system can produce diagnostic images comparable with pulsed fluoroscopic digital systems. The temporal filtering approach offers a real-time vascular imaging technique that requires no postprocessing and can be used either with arterial or intravenous injections of contrast materials.

Adult↗
PubMed1982

Digital subtraction angiography using a temporal bandpass filter: associated patient motion properties.

A system for performing real-time digital angiography both intraarterially and intravenously is described. A filtering process, rather than mask subtraction produces diagnostic-quality angiograms using existing fluoroscopic x-ray systems operated continuously (30 frames/sec) at less than 70 kVp and 20 mA. The image degradation effects of patient motion (breathing, swallowing, sudden movement) are dealt with differently from a subtraction approach. Certain periodic patient motions can be accommodated without the need for postprocessing. An analysis of experimental and clinical results of intravenous angiographic studies is presented, with emphasis on patient motion properties.

Angiography↗
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Adult↗