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Biomedical subjects

W Barthel

Publications and source records attributed to W Barthel.

At least 37 records · Page 2Linked to original sources

[Social fate (return to work) after coronary heart surgery and/or aneurysmectomy (author's transl)].

The "return to work"-rate of 4 groups of patients with myocardial infarction (MI) is evaluated (all coronary angiography): Group 1: 314 patients after aorto-coronary bypass operation: mean age 50.5 years. Time after infarction 28 months, after surgery 18 months. The social fate of 52% were not yet decided. 20% got pension, 25% returned to work. Group 2: 86 patients after conservative treatment of myocardial infarction: mean age 42 years. Time after MI 18 months. The social fate of 21% was not yet decided, 41% got pension, 36% returned to work. Patients with one-vessel disease returned to work in 52%, with two-vessel disease in 20% and with three-vessel disease in 12.5%. Group 3: 24 patients after aneurysmectomy: mean age 47 years. Time after infarction 28 months, time after operation 11 months. Social fate of 8 out of 24 patients was not yet decided, 7 out of 24 got pension, 5 out of 24 returned to work. Group 4: 27 patients with conservatively treated left ventricular aneurysm: mean age 43 years. Time after infarction 42 months. The social fate of 2 out of 27 patients was not yet decided, 14 out of 27 got pension, and 8 out of 27 returned to work. Exercise-tolerance is no good indicator for the work status 18 months after myocardial infarction, 18 months after aorto-coronary bypass, 18 months after aneurysmectomy and 42 months after conservative treatment of left ventricular aneurysm. Selection of patients (all were examined by coronary angiography because of limitation by angina pectoris in daily life activities) may be partly responsible for the poor long-term work status. But more important seems to be the "tied social network". Decision for "return to work" or "pension" should be made 6 months after MI or after operation.

Activities of Daily Living↗

[Myocardial scintigraphy (thallium-201) and electrocardiography at rest and during exercise in angina pectoris. A comparison with coronary angiography (author's transl)].

Ecg (at rest and during exercise) was compared to Thallium-201 myocardial perfusion imaging (at rest and after exercise) in 65 patients with coronary heart disease (myocardial infarction in 53 patients) and angina pectoris. These results were compared to coronary angiography and left ventricular angiography. Group I: (48 patients, comparison of Ecg at rest and Thallium-201 imaging at rest): 33 patients showed agreement of results. In comparison to angiography the 201-Thallium imaging showed less false-negative results than the Ecg as rest. Group II: (23 patients, comparison of Ecg during exercise with Thallium-201 imaging after exercise): 8 patients showed agreement, 15 patients did not. In comparison to angiography the imaging showed better agreement in 20 of 23 patients, the exercise Ecg in 14 of 23 patients. Exercise-Ecg showed false-negative results in 7 patients, Thallium-201 imaging in none. Especially in 1-vessel-disease imaging was superior. Group III: (24 patients, comparison of Ecg at rest and during exercise to 201-Thallium at rest and after exercise): In 19 patients results agreed almost. Because of background-correction imaging is inferior to the Ecg in the apical region. Imaging is superior to the Ecg in the septal and inferior-myocardial regions. Combination of both methods gives best correlations. Sensitivity of Ecg-results is 77% and in imaging 93%.

Adult↗

Studies on the inhibition of adrenaline-induced aggregation of blood platelets.

alpha-Adrenoceptors of platelets seem to differ from those of other cell types. The inhibitory effect of alpha-adrenoceptor-blocking agents on adrenaline-induced aggregation of human platelets does not parallel that on adrenaline-induced contraction of rabbit aortic strips. The most potent inhibitors of adrenaline-induced platelet aggregation are the dihydrogenated ergot alkaloids of the peptide type. Among the other ergoline derivatives testes, only lisuride has a stronger inhibitory effect than those of natural ergot alkaloids.

Adrenergic alpha-Antagonists↗

[Effect of ergoline derivatives on platelet and blood vessels].

The influence of dihydrogenated ergot alkaloids on vessels and blood platelets was studied in vitro and in vivo. At low concentrations they cause contraction of isolated vein strips via a stimulation of alpha-adrenoceptors, at higher concentrations they antagonize the action of noradrenaline on arteries and veins and inhibit the adrenaline-induced platelet aggregation in vitro. In volunteers, intravenous and subcutaneous administration of dihydroergotamine (Dihytamin) caused a decrease in blood volume of the capacitance vessels and inhibition of the adrenaline-potentiated platelet aggregation "ex vivo". The selective venoconstrictor and antiaggregating effects of dihydroergotamine are utilized in the postoperative prophylaxis of thrombosis.

Adrenergic alpha-Antagonists↗

Inhibition of adrenaline-potentiated thrombin-induced reaction of human blood platelets by dihydroergotoxine.

The potentiating effect of adrenaline on thrombin-induced aggregation and release reaction of human blood platelets has been studied in vitro. Both reactions are inhibited by low doses of dihydroergotoxine. The inhibition of aggregation is of competitive type. The adrenaline-potentiated thrombin-induced platelet aggregation is inhibited also after intravenous injection of dihydroergotoxine. The pathophysiological implications of these findings are discussed.

Blood Platelets↗