Disruption of the goblet cell intercellular junction following histamine infusion of the rabbit ileum.
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Biomedical subjects
Publications and source records attributed to W Baker.
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A 34-year-old woman with two congenital coronary aneurysms received a saphenous vein bypass graft (SVBG) as treatment for a thrombosed right coronary artery aneurysm 9 years ago. The angiographic and surgical findings were reported at that time [1]. In 1979, she received a sequential SVBG to the left anterior descending and first diagonal coronary arteries following recurrence of angina and progressive occlusion of the left coronary artery aneurysm. She is believed to have the longest angiographically documented course following operation, and her case history is reported to aid in establishing the natural history of this unusual condition and its surgical management.
Bilateral laryngeal paralysis is described in 5 Arabian and part-Arabian foals aged between 23 and 35 days. Tracheotomies resulted in complete relief of dyspnoea. Two cases showed recovery of abductor function of the right arytenoid cartilage after 3 weeks and one of these cases later recovered left abductor function. Four of the foals were autopsied at various times from one week to 6 months after the onset of respiratory obstruction. Histology of the recurrent laryngeal nerves showed active Wallerian degeneration and loss of nerve fibres in many fascicles in cases affected for one to 2 weeks. In the longer standing cases there was a severe deficiency of myelinated fibres. Histology of the dorsal and lateral cricoarytenoid muscles showed no abnormalities in the cases affected from one to 5 weeks. However, in the foal affected for 6 months there was variation in fibre diameter in the left dorsal cricoarytenoid muscle; in sections stained for myosin ATPase there was evidence of muscle fibre type grouping in both left and right dorsal cricoarytenoid muscles. It is postulated that the most likely cause of the condition was oral haloxon administration which was given to the foals at a dose rate of 1 to 2 g at fortnightly intervals, beginning at 2 days of age.
Sprague-Dawley rats made neutropenic by 60Co irradiation or cyclophosphamide treatment retained a limited capacity for mounting a local leukocyte mobilization (LLM) response. Rats irradiated with 700 rad 60Co lacked an LLM. Rats treated with 100 mg/kg cyclophosphamide showed no LLM following an initial low response when assayed originally.
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Workers at four different woodworking processes--two logging sites, four sawmills, one major woodchipping operation, and five joineries situated in the state of New South Wales in Australia--were studied for personal inhalable dust exposures (N = 182). The geometric mean exposure at logging sites was 0.6 mg/m3 (N = 7), sawmills 1.6 mg/m3 (N = 93), woodchipping 1.9 mg/m3 (N = 9), and joineries 3.7 mg/m3 (N = 66). Overall, 62% of the exposures exceeded the current standards. Among joineries, 95% of the hardwood exposures and 35% of the softwood exposures were above the relevant standards. A majority of workers (approximately 90%) did not wear appropriate respirators approved for wood dust, while the ones who did wear them, used them on average less than 50% of the time. The significant determinants of personal wood dust exposures (n = 163) were found to be local exhaust ventilation, job title, use of handheld tools, cleaning method used, use of compressed air, and green or dry wood processed. Type of wood processed (softwood or hardwood) was not found to be statistically significant.
An elevation of systolic and diastolic bloodpressure to values regarded as abnormal ones on the basis of conventional criteria was recognized by self-measurement. For both systolic and diastolic blood pressure, the overall means adjusted for rhythms, the so-called mesors, also were elevated in the light of their response to treatment: these mesors were found to be lowered with statistical significance when values during treatment were compared by an objective test with values measured before treatment. Individualized rhythmometry quantitatively characterizes a predictalbe portion of the variability in human blood pressure and tests for the statistical significance of changes in blood pressure as a function of the treatment and also as a function of the circadian timing of such treatment. The case report thus illustrates an individualized chronotherapy of systolic and diastolic mesor-hypertension, diagnosed retrospectively from the tested effect of hydrochlorothiazide. In the case reported, and perhaps routinely, computer-analyzed self-measurements can serve 1) to prescribe the right kind and amount with the right timing, for a given therapy, and 2) for diagnosis and prevention as well (Meyer et al.; Halberg et al.).
This pilot study was undertaken to better understand the families of patients with somatization disorder. Two complementary methods were used to study six patients with somatization disorder and six control patients. The first method was a semistructured clinical family interview which was videotaped and independently reviewed by five raters. The second method was by the PAFS-Q, a standardized family questionnaire. The clinical interview distinguished cases from controls both in terms of individual relationships and behavior of the family as a whole. The PAFS-Q also distinguished cases from controls, showing significantly more dysfunction for the cases on five of its eight subscales. These two methods overlap in the content areas of intimacy and individuation, with correlation coefficients between the two methodologies ranging from 0.45 to 0.79. The authors conclude that the families of patients with somatization disorder are different than their unaffected counterparts.
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