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Biomedical subjects

W BERNHARD

Publications and source records attributed to W BERNHARD.

At least 55 records · Page 3Linked to original sources
PubMed1956

Microbodies and the problem of mitochondrial regeneration in liver cells.

The cytoplasm of the hepatic cell contains, besides the well known organelles, microbodies, characterized by a single membrane, a finely granular matrix, and average dimensions below those of mitochondria. Microbodies, rare in normal cells, become more numerous in regenerative livers and in various pathological conditions. In these cases, they either evolve towards degenerative forms or else show structural modifications corresponding to transitional forms between them and mitochondria. This suggests to us that the microbodies can be precursors of mitochondria.

Cytoplasm↗
PubMed1956

Close topographical relationship between mitochondria and ergastoplasm of liver cells in a definite phase of cellular activity.

1. In most rat liver cells, no special topographical relationship between mitochondria and ergastoplasmic lamellae is to be observed. In some cells, nevertheless, the two organelles are grouped together in dense zones clearly separated from the hyaloplasm. 2. Such an association can be produced at will in the livers of animals refed after prolonged fasting, or in the regenerative phases after partial hepatectomy and intoxication with carbon tetrachloride. In all these cells, the ergastoplasm, after having disappeared, suddenly reappears in the cytoplasm, either along the nucleus or cell membranes, where the mitochondria are grouped. 3. It may be supposed that these topographical relationships between mitochondria and ergastoplasm during a definite period of cellular activity indicate a close functional link between chondrioma and basophilic structures. Mitochondria seem to play an important part in the elaboration of hepatic ergastoplasm.

Animals↗