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Biomedical subjects

W B White

Publications and source records attributed to W B White.

At least 163 records · Page 9Linked to original sources
PubMed1985

Incidental finding of intense thyroid radiogallium activity during febrile illness.

Two elderly adults presented with fever of undetermined origin. Radiogallium imaging showed intense concentration in the thyroid, without abnormal localization elsewhere. In the first case, a repeat radiogallium study performed three weeks later was within normal limits. The patient had 0% uptake of radioiodide, and no demonstrable iodine within the thyroid. This probably represented thyroiditis. In the second case, an elevated T4 (RIA) and borderline elevated T3 resin uptake suggested the "dumping phase" of thyroiditis. The two cases indicate that "benign" diseases of the thyroid can be associated with diffuse radiogallium concentration in the gland.

Aged↗
PubMed1985

Assessment of blood collection systems for the high performance liquid chromatography measurement of propranolol.

The effect of blood collection devices on the high performance liquid chromatography (HPLC) measurement of propranolol was assessed. Blood was collected from hypertensive patients treated with propranolol for at least 7 days. Two venipunctures (opposite arm technique) were performed on each patient using the reference (syringe/silanized, ethylene diamintetraacetate tubes) procedure and the Vacutainer Brand Tubes (lavender-, royal blue-, green-, and red-stoppered) that were free of tris(2-butoxyethyl) phosphate. Propranolol concentrations were determined utilizing a published HPLC procedure. This study showed that in the four evacuated tubes, propranolol concentrations in serum or plasma were highly correlated to those of the reference procedure (correlation coefficients, 0.986 to 0.997; and slope, 0.912 to 1.013). Mean propranolol concentrations of the red-stoppered tube serum were lower (7.5%) than that of the reference syringe (0.01 less than p less than 0.05). Thus, lavender-, royal blue-, green-, and red-stoppered tubes would be acceptable for propranolol monitoring.

Blood Specimen Collection↗
PubMed1985

Beta blockers with intrinsic sympathomimetic activity.

A new class of beta-adrenergic blockers with the pharmacologic property of intrinsic sympathomimetic activity (ISA) is emerging for use in the treatment of hypertension. These agents decrease blood pressure and systemic vascular resistance, while the heart rate and cardiac output at rest are maintained. Beta blockers with ISA may be used in clinical situations where non-ISA beta blockers are relatively contraindicated, such as sinus bradycardia, sick sinus syndrome, Raynaud-like symptoms and chronic obstructive lung disease.

Adrenergic beta-Antagonists↗
PubMed1985

Drugs for cough and cold symptoms in hypertensive patients.

Most cold preparations contain sympathomimetic decongestants in combination with antihistamines, anticholinergics or expectorants. All of the sympathomimetic decongestants have the potential to elevate blood pressure, yet little information has been reported on their use in patients with hypertension. Phenylephrine and phenylpropanolamine stimulate alpha-adrenergic receptors, causing elevation of blood pressure and a reflex decrease in heart rate. Ephedrine and pseudoephedrine stimulate both alpha and beta receptors, elevating blood pressure with an increase or no change in heart rate. Because little is clinically known, these agents should probably be avoided in hypertensives.

Antitussive Agents↗
PubMed1985

Aggravated CNS depression with urinary retention secondary to baclofen administration.

A 74-year-old woman with a history of cerebrovascular disease developed profound central nervous system (CNS) and respiratory depression, generalized hypotonia, sinus bradycardia, and urinary retention following an increase in dose of baclofen, an antispasticity agent. Before receiving baclofen therapy the patient had had minor urinary dysfunction associated with a remote cerebrovascular accident but no urinary retention. Cessation of baclofen therapy and the relief of the urinary obstruction improved mental status and normalized motor function within 24 hours. A withdrawal syndrome of agitation, hallucinosis, and convulsive activity persisted for eight days following discontinuation of the baclofen. Our experience suggests that patients with various forms of CNS disease states may be at risk of serious CNS depression with even small therapeutic doses of baclofen.

Aged↗
PubMed1984

Transmission of herpes simplex virus type 1 infection in rugby players.

Skin infections, both bacterial and viral, are endemic in contact sports such as wrestling and rugby football. In this report, we describe four cases of extensive cutaneous herpes simplex virus in players on a rugby team. All players had a prodrome of fever, malaise, and anorexia with a weight loss of 3.6 to 9.0 kg. Two players experienced ocular lesions associated with cutaneous vesicular lesions of the face. A third player, who had herpetic lesions on his lower extremity, experienced paresthesias, weakness, and intermittent urinary retention and constipation. All infected players on the team were forwards or members of the "scrum," which suggests a field-acquired infection analogous to the herpetic infections seen in wrestlers (herpes gladiatorum). Considering the serious sequelae of recurrent herpes simplex keratitis, the traumatic skin lesions in rugby football players should be cultured for herpes virus, and infected individuals should be restricted from playing until crusted lesions have disappeared.

Adult↗
PubMed1984

Hydralazine hoarseness. A new appearance of drug-induced systemic lupus erythematosus.

Otolaryngologic involvement is rarely a manifestation of drug-induced systemic lupus erythematosus (SLE). Hoarseness developed in a 60-year-old man that was secondary to ulcerated lesions, which involved the epiglottis and aryteno-epiglottic folds, with serologic evidence of SLE after he had been treated with hydralazine for six months. Histopathologic study of an epiglottic "pseudotumor" disclosed necrotizing vasculitis. To our knowledge, this is the first reported case of laryngeal involvement as a complication of hydralazine-induced SLE.

Epiglottis↗
PubMed1984

Systemic herpes simplex virus type 2 infection. Proctitis, urinary retention, arthralgias, and meningitis in the absence of primary mucocutaneous lesions.

A 24-year-old heterosexual man had severe proctalgia associated with nonspecific proctitis. Within a few days, perineal and lower extremity paresthesias, intermittent urinary retention, inguinal lymphadenopathy, lower extremity arthralgias, and aseptic meningitis developed. Serologic studies demonstrated a fourfold rise in convalescent antibody titer to herpes simplex virus (HSV) consistent with an initial type 2 infection. Six months later, HSV type 2 was isolated from perianal vesicles, which we believe was the first cutaneous manifestation of a recurrence. This unusual syndrome, presumably the result of HSV ganglionitis, could be confused with other disorders that include multiple sclerosis, lumbar disk disease with radiculopathy, rheumatologic disease, and psychogenic illness. In the absence of typical herpetic mucocutaneous vesicles, serologic studies may be useful in the diagnosis of a systemic herpes simplex infection.

Adult↗
PubMed1984

The attack on TAC.

Explore the source record for details and available documents.

Anesthesia, Local↗
PubMed1984

Basal cell carcinoma of the anus: clinical and pathological distinction from cloacogenic carcinoma.

A 54-year-old man developed basal cell carcinoma of the anal verge. This extremely rare tumor behaves rather innocently, whereas cloacogenic carcinoma of the anus, which resembles it histologically, metastasizes early and often proves fatal. Clinical and histopathologic characteristics of the two anal neoplasms are tabulated to facilitate differential diagnosis, and thereby promote their very different therapies.

Anus Neoplasms↗
PubMed1984

Metrizamide meningitis.

A 39-year-old man had fever, nuchal rigidity, vomiting, and mental confusion within 24 hours after myelography with metrizamide, a water-soluble contrast medium. Cloudy cerebrospinal fluid showing pleocytosis, a significantly elevated level of protein, and a low glucose value suggested septic meningitis, but rapid resolution of signs of meningeal irritation and negative spinal fluid cultures made chemical meningitis due to the metrizamide the likely diagnosis.

Adult↗
PubMed1984

Atenolol in human plasma and breast milk.

To assess the problem of continuing atenolol in a breast-feeding mother with hypertension associated with thyrotoxicosis, studies were performed to determine simultaneous plasma and breast milk concentrations of atenolol after a single dose of 50 mg and on continuous therapy of varying weekly dosages. Peak atenolol concentrations in breast milk were 3.6 times higher than simultaneous plasma atenolol concentrations after single-dose administration and 2.9 times higher after continuous-dose administration. A single plasma concentration obtained in the infant following a peak level feeding was less than 10 ng/ml. Although it would seem unlikely that the amount of atenolol excretion in breast milk should warrant interruption of breast-feeding because of maternal medication with ordinary doses, the infant should be evaluated for signs of beta-blockade.

Adult↗
PubMed1983

Severe delayed inflammatory reactions from injected insulin. Association with cell-mediated immunity.

A diabetic patient had severe, delayed cutaneous reactions to insulin accompanied by fever, leukocytosis, and elevated erythrocyte sedimentation rate. Replacement of isophane beef-pork insulin suspension with other commercially available lente beef-pork, single-component beef and pork insulin preparations brought about no improvement. Intradermal testing demonstrated biphasic reactions to a wide variety of insulin preparations except for two recently available purified single-component (less than 1 ppm proinsulin) insulins. Immunologic studies showed increased incorporation of tritiated thymidine by the patient's peripheral blood lymphocytes after incubation with these insulin preparations that incited subcutaneous and intradermal reactions. Additionally, there was significant elaboration of the lymphokine, migration inhibitory factor, in response only to isophane beef-pork insulin. Control lymphocytes from a normal subject, from a patient with non-insulin-dependent diabetes, and from a patient with insulin-dependent diabetes without delayed allergy demonstrated no response to insulin preparations. The data suggest these delayed reactions were associated with a cellular immune response to one or more contaminants in the less purified insulin preparations.

Diabetes Mellitus↗