Letter: Vitamin E treatment of dermolytic bullous dermatoses.
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Biomedical subjects
Publications and source records attributed to W B Reed.
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Tuberous sclerosis is essentially a hereditary disease dominated by hamartomas in various organs. Symptoms of the disease are referable to expanding growth of these hamartomas, especially in the kidney where these benign lesions most often present with pyuria, hematuria or pain from bleeding. They are apt to be erroneously diagnosed as malignant both clinically and microscopically. Renal symptomatology is most often to be found in the adult patient.
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There are a great number of genetic and congenital disorders with skin manifestations ("genodermatoses") with tumor formation. Some of these tumors are benign (hamartomas, in part) and others are malignant. There is a large group of heredodegenerative disorders with such complications as lymphosarcoma and leukemia. There are congenital tumors with malignancy developing. Lastly, there are the chromosomal abnormalities with skin manifestations and tumors, usually malignant. This will be an ever increasing field and the use of fibroblast and virus cultures will become more important in ascertaining the cause of malignancy.
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