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Biomedical subjects

W B Jackson

Publications and source records attributed to W B Jackson.

51 records · Page 3Linked to original sources
PubMed1980

Masquerade syndrome.

A 52-year-old man experienced chronic blepharoconjunctivitis of the right eye of the three years' duration that was unresponsive to medications. Conjunctival cytologic examinations suggested carcinoma and this was confirmed. However, only a full-thickness eyelid biopsy established that the tumor was a sebaceous carcinoma. We discuss the importance of considering this condition in all cases of unilateral, persistent, or recurrent eyelid inflammation resistant to the usual therapy; the diagnostic value of conjunctival scrapings and full-thickness lid biopsy; and the necessity of interpretation of the biopsy material by a pathologist experienced with, and alerted to look for, this neoplasm. Early recognition of sebaceous carcinoma followed by prompt adequate therapy should improve the survival of patients with this rare but malignant tumor.

Blepharitis↗
PubMed1980

Mucosal cyst of lacrimal gland fossa simulating lacrimal gland neoplasm.

A 28-year-old man presented with an orbital tumour that was localized by computérized tomography to the fossa of the right lacrimal gland. A benign mixed tumour of the lacrimal gland was the clinical diagnosis, but lateral orbitotomy revealed a subperiosteal cystic mass in the lacrimal gland fossa that extended superiorly and medially into the frontal sinus. Light microscopic examination showed a cyst lined by nonkeratinized stratified squamous epithelium with occasional goblet cells; blood products were present in the lumen, and a chronic inflammatory cell infiltrate was noted in the subepithelial tissue. The possible origins of this mucosal tissue are discussed.

Adult↗
PubMed1979

A congenital ichthyosiform syndrome with deafness and keratitis.

This is a report on two children with a syndrome characterized by an extensive congenital ichthyosiform eruption, neurosensory deafness, hypotrichosis, partial anhidrosis, and vascularization of the cornea. The facial involvement is distinctive. Other features are dystrophy of the nails and tight heel cords. Both children are of normal intelligence. The inheritance pattern is unknown.

Child↗
PubMed1978

The TRH test: its value in the diagnosis of Graves' ophthalmopathy.

When a goiter or hyperthyroidism is absent, the diagnosis of ophthalmic Graves' disease is often difficult. We evaluated the thyrotropin (TSH) response to intravenously administered thyrotropin-releasing hormone (TRH) in fourteen patients presenting with proptosis or lid retraction. All of them had normal results with routine thyroid function tests and in most a T3 suppression test and orbital ultrasonography were performed. We found an absent or impaired response to TRH in the patients with Graves' ophthalmopathy which correlates well with their having a non-suppressible thyroid gland. Patients with orbital tumours, pseudotumours or congenital lid retraction responded normally to TRH. The TRH test was easier and as reliable as the T3 suppression test in the investigation of a patient with suspected Graves' disease.

Adolescent↗
PubMed1978

Talc retinopathy.

We observed talc particles in the retinal vessels of nine out of 17 addicts to intravenous methadone. The retinopathy was found in patients who had injected more than 9,000 tablets. In seven the chest roentgenograms showed a diffuse micronodular pattern which progresses to resemble massive pulmonary fibrosis and is associated with severe disability. The ophthalmologist must recognize this entity since he may be the first to identify drug abusers who inject oral medications containing talc. Early detection and counselling may prevent the severe pulmonary complications.

Adult↗
PubMed1975

Adenovirus type 19 keratoconjunctivitis in Canada.

We describe an outbreak of epidemic keratoconjunctivitis occurring in Montreal during the winter of 1974. Adenovirus type 19 was the only virus isolated. We confirm the presence of type 19 adenovirus in Canada; it produces severe keratoconjunctivitis. The incubation period, method of spread and clinical findings resemble those seen in outbreaks of type 8 EKC. The prevalence of adenovirus type 19 in the population of Canada is unknown. Although some object to the use of the term EKC for infection caused by adenoviruses other than type 8, we believe that EKC should be regarded as an entity requiring virus isolation and antibody determination to identify the adenovirus type responsible for it.

Adenoviridae↗
PubMed1974

Plate hemolysin test for the rapid screening of toxoplasma antibodies.

A plate hemolysin test was developed to screen serum specimens for the presence of toxoplasma antibodies. When we tested 130 sera by both this test and the standard toxoplasma dye test, we found the plate hemolysin test to be a rapid, sensitive, and economical method for detecting toxoplasma antibodies. In all but one instance it paralleled the dye test. A comparison of the results of testing six sera by the hemolysin, hemagglutination, and dye-test techniques suggested that the hemolytic antibodies were more closely related to hemagglutinating antibodies than to dye-test antibodies. We could not store sheep erythrocytes sensitized with toxoplasma lysate for more than 3 days without altering the sensitivity of the test. Concanavalin A proved to be an effective coupling agent for binding toxoplasma antigens to red-cell membranes, a quality attributed to its affinity for specific polysaccharide-combining sites.

Animals↗
PubMed1972

Resistance of wild Norway rats in North Carolina to warfarin rodenticide.

Reports concerning the ineffectiveness of warfarin rodenticide, used at farms and stores in a rural area about 8 kilometers in diameter near Raleigh, North Carolina, prompted subsequent laboratory testing. All of the 25 Norway rats trapped from the area survived 6 days of no-choice feeding of bait containing 0.025 percent (by weight) warfarin.

Animals↗
PubMed1972

Biological and behavioural studies of rodents as a basis for control.

Domestic rodents, particularly those living in urban populations, represent a serious public health problem, and effective control measures are required to deal with this threat to human health. Because of the characteristic interactions between individual animals, certain behaviour patterns occur in rodent populations that are of particular concern to control biologists. The genus Rattus is an extremely diverse group whose ecological requirements are variable and flexible, while the genus Mus, on account of its small size, limited range, and modest requirements in terms of food and water, is also very difficult to control. For any control operation a knowledge of the growth dynamics of domestic rodent populations is needed; after a period of logarithmic growth, population increases cease when the habitat is fully exploited. Consequently, control operations that merely remove some animals lead only to renewed population growth. Trapping, poisoning, and predation are traditional control measures of this kind. Environmental modification is a more certain, but more difficult, approach. The use of chemosterilants offers some hope of radical control in the future, but at present, although some field trials have been made, these substances are not available for general use, one reason being their lack of specificity. Another problem connected with the use of chemosterilants is that, on account of the sexual behaviour and physiology of domestic rodents, it would be necessary to reach nearly 100% of the population to obtain effective control.

Animals↗
PubMedDate not supplied

Differentiating conjunctivitis of diverse origins.

While symptoms can be very distressing, patients with conjunctivitis general maintain good vision and recover completely without permanent sequelae. The great majority of cases of conjunctivitis are infectious or allergic in origin. Seen with increasing frequency are external eye diseases related to contact lens wear or prolonged use of ophthalmic medications. The various forms of conjunctivitis are often not associated with pathognomonic features. A thorough history and ophthalmic examination often permit a presumptive diagnosis and initiation of empiric therapy. For example, a chronic bilateral conjunctivitis, characterized by itching and papillary hypertrophy, suggests an ocular allergy, most frequently the result of exposure to airborne allergens. However, a number of causes, including infections and hypersensitivity reactions, have the potential to threaten vision or produce marked conjunctival scarring which must be identified by the use of appropriate laboratory techniques, followed by specific therapy. Most bacterial and viral conjunctivitis are self-limited, but antimicrobial therapy for the former is advocated to shorten the course, improve patient comfort, prevent recurrence, avoid complications and limit spread to other individuals.

Blepharitis↗