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Biomedical subjects

W Auerswald

Publications and source records attributed to W Auerswald.

At least 19 recordsLinked to original sources
PubMed1982

Plasminogen activator activity in the aorta of strains of rats with genetically determined different patterns of lipids in the blood. Induction of increased activity by streptozotocin.

In a strain of genetically hypercholesterolemic rats (RICO), developed from an albino mutant of Rattus norvegicus (Sprague-Dawley, Tif: RAIf, SPF) by selective breeding, the intimal plasminogen activator activity (PAA) at the nonbranching regions of the aorta was markedly lower than at the nonbranching regions of the aorta in the control strain (Sprague-Dawley). At the branching regions of the aorta the intimal PAA showed no difference between the two strains of rats. In another strain of rats (HBC; hyper-beta-cholesterolemic) with a slightly elevated level of total cholesterol in the blood, a high concentration of LDL-cholesterol and a low concentration of triglycerides, the intimal PAA showed no difference from that in the control strain (Sprague-Dawley) at the branching and nonbranching regions of the aorta. 6 weeks after a single injection of streptozotocin at a diabetogenic dose (45 mg/kg) into RICO rats and the control strain, the intimal PAA was found to be increased by 280% in RICO rats, but only by 140% in controls, compared to that in the corresponding nontreated rats.

Animals↗
PubMed1980

[Metabolic indicators ("risk factors") in atherosclerotic coronary heart diseases and the ability to influence these factors by diet].

In view of current interest in the so-called "risk factors" of atherosclerotic cardiovascular diseases and the usefulness of preventive dietary measures, a review is given of the published data from long-term prospective studies. Opinions concerning the importance of the various lipoprotein classes as risk factors and reports of a decrease in the concentration of the allegedly "protective" high-density lipoproteins by consumption of polyunsaturated fatty acids are discussed. An up-to-date summary of current scientific developments relative to this problem is presented.

Cholesterol, Dietary↗
PubMed1980

Prostacyclin (PGI2)-generation by different types of human atherosclerotic lesions.

Unaltered human arterial tissue as well as different types of macroscopically and microscopically characterized atherosclerotic lesions were microdissected under a preparation microscope. The prostacyclin formation was examined using its potent platelet aggregation inhibition in vitro according to Moncada's bioassay. In contrast to different PGI2-formation in various experimental animal models the generation in the different lesion types in terms of wet weight was statistically significantly (p less than 0.001) diminished in comparison to normal control tissue. However, the PGI2- formation in different lesion types is comparable. Accepting the hypothesis delivered earlier by us, that the arterial wall is able to react upon exogenous noxes with a temporarily enhanced PGI2-formation, followed (after ceasing) by a decrease of PGI2-synthesis (exhaustion phenomenon) it can be concluded, that the critical stage is prior to the fatty streak formation, which is a preatherosclerotic lesion. Therefore, PGI2-generation-exhaustion might be mainly responsible for initiation and progression of atherosclerosis, probably before any detectable morphological alterations.

Aged↗
PubMed1980

Quantitative investigation of sudanophilic lesions around the aortic ostia of human fetuses, newborn and children.

The sudanophilic lesions around the aortic ostia of 10 fetus, 10 newborns and 10 children aged up to 1 year were studied using a polar coordinate mapping method. The periorificial sudanophilic lesions develop initially distal to the orifices and show a continuous increase with age in percentage and extent. In children the lesions nearly completely surround all the ostia with a significant distal peak. There was no sex difference; the involvement of the right and left side was comparable. The comparison of the morphological data from the parents and children with anamnestics showed no relationship.

Adipose Tissue↗