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Biomedical subjects

W Arnold

Publications and source records attributed to W Arnold.

At least 487 records · Page 27Linked to original sources
PubMed1975

[Clinical importance of hepatitis B antigen (author's transl)].

The clinical importance of the hepatitis B antigen (HBsAg) is based mainly on the differentiation between different courses of inflammatory liver diseases and/or nonvirus induced diseases of the liver. Epidemiologic studies have shown that beside a parenteral inoculation there is a possibility of a non-parenteral inoculation. Furthermore, there is evidence that the sporadic hepatitis is more commonly hepatitis B. Epidemiologic investigations revealed that clinically healthy HBsAg carriers, the "carrier" status in immunodeficiency syndromes and the natural circulation of the hepatitis B virus are of major interest. The demonstration of HBsAg enables us to characterize some diseases which show associations to hepatitis B virus, but where the pathogenic role of HBsAg/Ab immunocomplexes is questionable. Furthermore, it was possible by the detection of HBsAg to establish newer therapeutic and preventive interventions of virus B hepatitis.

Adult↗
PubMed1975

Studies on the pathogenesis of chronic inflammatory liver diseases. I. Membrane-fixed IgG on isolated hepatocytes from patients.

Membrane-fixed IgG on isolated hepatocytes from biopsy material could be demonstrated by direct immunofluorescence in nine of thirty-four patients with acute virus-B hepatitis and in seventeen of forty-nine cases with chronic active hepatitis (CAH). Patients with acute virus-A hepatitis, chronic persistent hepatitis (CPH) or metabolic liver diseases did not show this phenomenon. Cases with CAH and IgG on the hepatocytes-HBsAg-positive as well as HBsAg-negative-had high inflammatory activity. Antibodies against HBsAg were not present in any serum. Autoimmune phenomena (antibodies against smooth muscle, mitochondria and nuclei) were only rarely demonstrable. The findings suggest that an antibody- or immune complex-mediated lymphocyte cytotoxicity may be involved in the pathogenesis of chronic liver diseases.

Antibodies↗
PubMed1974

Photochemical activity of single chloroplasts recorded by the use of nuclear track emulsion.

The photochemistry done by single chloroplasts can be measured when the chloroplasts are embedded in nuclear track emulsion. It has been known for more than 50 years that certain chemicals will blacken photographic plates (chemical fogging). Although this effect has been little used to measure chemical reactions, it may be particulary useful in photochemistry and electrochemistry, since as little as 10(-18) mole can be measured.

Chloroplasts↗