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Biomedical subjects

W Adam

Publications and source records attributed to W Adam.

At least 109 records · Page 6Linked to original sources
PubMed1986

[The pattern of regional disorders of wall motion in primary dilated cardiomyopathy].

Regional left ventricular wall motion was measured in 41 patients with dilated cardiomyopathy (DCM) and 30 healthy normal controls. Global and regional left ventricular function was noninvasively determined by radionuclide angiography (RNA). The amplitudes and phases of the first Fourier coefficient of the regional time-activity curves were used to measure regional wall motion. The normal left ventricle has its strongest contractions in the apical and distal antero-septal regions. In contrast, the left ventricle of patients with DCM contracts the least in these segments. These regional wall motion impairments are parallel to the reduced global left ventricular function. Since such a typical pattern of reduced wall motion can already be demonstrated in patients with mild DCM, determination of regional left ventricular wall motion can help to improve the early detection of DCM.

Cardiac Output↗
PubMed1985

[Education of the dermatologist in medical mycology].

Principal considerations on graduate medical education in mycology revealed that it should be more effective. For this purpose, an intensive training program has been performed at our department. Here we report on our experiences with this conception as well as our conclusions drawn from it.

Curriculum↗
PubMed1985

Right ventricular function in patients with chronic obstructive pulmonary disease.

Simultaneous right heart catheterization and radionuclide ventriculography were performed in 27 patients with a wide range of chronic obstructive pulmonary disease. Central hemodynamics and radionuclide studies were done at rest and during exercise. In the resting state the right ventricular ejection fraction (RVEF) was in the normal range (43.3 +/- 6%). During exercise a significant (p less than 0.001) decrease of RVEF to 38.8 +/- 6.7% occurred. The pulmonary artery mean pressures were 19.9 +/- 3.8 at rest. During exercise a significant (p less than 0.001) increase to 41 +/- 9.8 mm Hg occurred. There was a linear relationship between pulmonary pressures and RVEF during exercise in patients with pulmonary artery pressures not exceeding 35 mm Hg. In patients with right ventricular end-diastolic wall thickness greater than or equal to 6 mm a curvilinear relationship between these parameters could be observed with a flattening of the curve at higher pressures (greater than 35 mm Hg) and lower ejection fractions (less than 35% RVEF). Radionuclide ventriculography cannot substitute for right heart catheterization. Echocardiography is useful for interpretation of right ventricular ejection fractions in advanced chronic obstructive pulmonary disease.

Aged↗
PubMed1984

Adverse reactions to long-term diuretic therapy for hypertension.

Diuretics are important drugs used in therapy for hypertension. Diuretics have a number of side effects, some of which have long-term consequences. In this study diuretics were used to treat individuals with mild hypertension. Patients receiving diuretics as sole therapy had an increased mortality due to an excess number of deaths from myocardial infarction or sudden death. In patients given alpha-methyldopa or propranolol as well as a diuretic drug, this effect was not observed. The increased mortality may be due to an increased susceptibility to arrhythmias in individuals receiving diuretics, and this was prevented by drugs that interfere with the effects of the sympathetic nervous system.

Adrenergic beta-Antagonists↗
PubMed1984

Effect of changes in sodium intake on cell transport parameters.

Changing sodium intake from 70-200 mmol/day elevates blood pressure in normotensive volunteers by 6/4 mmHg. Older people, people with reduced renal function on a low sodium diet and people with a family history of hypertension are more likely to show this effect. The rise in blood pressure was associated with a fall in plasma volume suggesting that plasma volume changes do not initiate hypertension. In normotensive individuals the most common abnormality in membrane sodium transport induced by an extra sodium load was an increased permeability of the red cell to sodium. Some normotensive individuals also had an increase in the level of a plasma inhibitor that inhibited Na-K ATPase. These individuals also appeared to have a rise in blood pressure. Sodium intake and blood pressure are related. The relationship differs in different people and is probably controlled by the genetically inherited capacity of systems involved in membrane sodium transport.

Biological Transport↗
PubMed1984

[Partial lipodystrophy syndrome (Dunnigan type)].

Special forms of partial lipodystrophy, which in contrast to the progressive lipodystrophy of Barraquer-Simons spare the face, have been reported by Dunnigan and Köbberling. Lipodystrophy of the Dunnigan type affects the trunk and limbs; in lipodystrophy of the Köbberling type the loss of subcutaneous fat is restricted to the extremities. The following case report deals with the main clinical and laboratory findings in lipodystrophy of the Dunnigan type.

Acanthosis Nigricans↗
PubMed1984

Routine microscopic examination of the urine sediment. Should we continue?

Our study attempted to answer the following questions: What percentage of patients at routine hospital admission have notable urine sediment abnormalities? Is the urine specific gravity related to the yield of sediment abnormalities? Is there an increased yield of sediment abnormalities when the test is specifically requested by the physician? Of 442 patients admitted to the hospital, microscopic sediment abnormalities were present in 28%. In one half of these, the only abnormality was the presence of WBCs. There was no relationship between the yield of microscopic abnormalities and urine specific gravity. When the examination was specifically requested by the physician, our work load dropped by 75%. However, surprisingly, the yield of abnormalities did not increase. Therefore, we recommend that microscopic sediment examination be performed on every patient admitted to the hospital.

Diagnostic Tests, Routine↗